Search PubMed⌕ Search

Biomedical subjects

T Suslow

Publications and source records attributed to T Suslow.

15 recordsLinked to original sources
PubMed2001

Attention training in the cognitive rehabilitation of schizophrenic patients: a review of efficacy studies.

OBJECTIVE: To review the literature on effects of attention and cognitive training on attentional functioning in schizophrenic patients. METHOD: Relevant efficacy studies were identified by literature searches (in Medline, Current Contents, Psyclit, and Psyndex databases) and through the reference lists of key papers. RESULTS: Re-examination of findings from nine methodologically adequate studies using computer-based or non-computer-based training procedures provided inconsistent results. On 16 of 35 outcome measures significant performance improvements were observed from pre-treatment to post-treatment but on the majority of the applied measures no performance improvement could be determined. In general, treatment effect sizes but also power of tests were low. For nearly all the outcome measures for which differential training effects were reported there also exist contradictory outcome results. CONCLUSION: There is inconclusive evidence that attention training is effective in schizophrenia. Longitudinal efficacy studies are needed in which different aspects of attention are systematically exercised and assessed.

Attention↗
PubMed2001

[A critique of the construct "alexithymia" and its measurement--the weakness of self-report and the opportunities of an objective assessment approach].

Approximately thirty years ago the term alexithymia was coined but it is still open which characteristics have to be considered core symptoms of alexithymia. A selective review of recent expert definitions reveals dynamism in defining the alexithymia construct. At present, the self-report Toronto-Alexithymia-Scales (TAS) are the most frequently used measures of alexithymia. Empirical findings regarding various aspects of validity (factorial, concurrent, and experimental construct validity data) question the validity of the Toronto-Alexithymia-Scales. Alexithymia as measured by the TAS appears not to be consistently related to physiological, affect decoding or affective vigilance characteristics. The heterogeneity of the results could be due to the fact that non-alexithymic persons such as depressed or socially anxious individuals yield high scores on the TAS; on the other hand self-report appears to be in principle a methodologically inadequate approach for the assessment of alexithymia. Objective or direct measures of alexithymic characteristics as the Levels of Emotional Awareness Scale or the prototypicity analysis of mood diaries based on adjective checklists seem to be promising assessment methods for future research.

Affective Symptoms↗
PubMed2001

Detection of facial expressions of emotions in depression.

Research on perceptual and attentional processes in depression has shown that depressed as opposed to nondepressed individuals do not exhibit a positive perceptual bias in multistimulus representations. In the present study a face-in-the-crowd task was applied to examine the relationship between depression and spatial detection of facial expression of positive and negative emotions. A face-in-the-crowd task was administered to 30 subjects (15 clinically stabilized depressed inpatients and 15 normal subjects) using displays of schematic faces. Depressed subjects showed no performance differences in the detection of negative faces and no differences in decision latency for the control condition (all neutral faces) compared to normal subjects. Depressed subjects, however, were significantly slower in responding to positive faces than normal subjects. Our data suggest that depressive mood is associated with a reduced spatial attention to positive facial expression and not with an abnormal spatial processing of negative facial expression. An implication is that lowered vigilance for facial expressions of joy and happiness may affect adversely interpersonal relationships in depressed subjects.

Adult↗
PubMed2000

20-Item Toronto Alexithymia Scale: do difficulties describing feelings assess proneness to shame instead of difficulties symbolizing emotions?

A hallmark of alexithymia is the difficulty putting emotional states into words which has to be differentiated from problems to communicate emotion to others. Shame proneness is a personality trait that is expected to be closely related to a reduced emotional self-disclosure in social interactions. The present investigation was conducted to examine construct validity of the Difficulties Describing Feelings scale of the 20-Item Toronto Alexithymia Scale (TAS-20). The TAS-20 was administered to 68 subjects (30 psychiatric inpatients and 38 normals) along with the Levels of Emotional Awareness Scale (LEAS), a direct measure of the ability to express feelings verbally, and the Shame-Guilt-Scale. Difficulties Describing Feelings was associated with shame assessing scales but not with guilt assessing scales or the LEAS. Thus, in view of our data one should be cautious in interpreting scores from the TAS-20 scale Difficulties Describing Feelings as indices of a difficulty to symbolize one's emotions. Instead, this TAS-20 scale seems to evaluate aspects of social shame.

Adult↗
PubMed1999

Comorbidity of schizophrenia and prelingual deafness: its impact on social network structures.

BACKGROUND: Prelingually deaf persons usually gain only a rudimentary command of speech and prefer sign language to communicate within the deaf community without the handicap they experience in the hearing world. Maintaining social contact within this rather scattered community, however, requires higher degrees of social initiative and mobility. The aim of the present paper was to study the quantity and quality of social integration among a group of prelingually deaf schizophrenic patients (n = 49) and two control groups comprising prelingually deaf psychiatric but non-psychotic patients (n = 38) and hearing schizophrenic patients (n = 30), with account being taken of the special socialisation conditions of deaf persons and of their cultural standards and values. METHOD: Data were collected with the help of semi-structured interviews; with the deaf patients these were conducted in German sign language. Using rating procedures we assessed seven social support components, selected items from a history schedule for schizophrenia, and the probands' visual and verbal language skills. RESULTS: The social networks of the two deaf groups were found to have larger gaps than those of the hearing schizophrenic patients, with significant differences being registered most clearly in the comparison between deaf schizophrenic and hearing schizophrenic patients. Comparison of the verbal and visual language skills of the two deaf groups revealed a substantial deficit among the deaf schizophrenics. Visual language skills were found to correlate more strongly than verbal language skills with the social support components. CONCLUSION: Prelingual deafness has a strong impact on the course of schizophrenia. In the long run, many of these patients belong to a "minority within a minority".

Adult↗
PubMed1998

Backward masking in schizophrenia: time course of visual processing deficits during task performance.

Backward masking deficits have been put forward as potential psychological markers for vulnerability to schizophrenia. This study was conducted to investigate whether schizophrenic patients improve their performance on a backward masking task during a single test session. The ability of a degraded stimulus version of the masking task to act as a specific diagnostic marker for paranoid schizophrenia (versus affective disorder) was also investigated. The backward masking task was performed on 18 paranoid schizophrenic patients, 18 unipolar depressed patients, and 18 non-psychiatric controls. Paranoid schizophrenic patients were included because they tend to show normal performance with traditional masking protocols. Schizophrenic patients made significantly more detection errors compared to depressives and non-psychiatric controls where interstimulus intervals (ISIs) longer than 14 ms were used. Unlike depressed patients and non-psychiatric controls, schizophrenic patients showed no reduction in error rate during the entire period over which the backward masking task was performed. The constant error rate which was observed at an ISI of 114 ms suggests that schizophrenic patients cannot attenuate the disruption effect due to deflection of attention from the target to the mask. The backward masking deficit in schizophrenia appears to arise from a temporarily stable visual processing impairment in performance within a single test session.

Adult↗
PubMed1998

Differential validity of the Gottschalk-Gleser Anxiety Scales: is gender a moderator variable?

It can be hypothesized that affects like anxiety can be measured by content analysis of speech due to the phenomenon of mood congruent memory, which is found predominantly in females. To assess the effect of gender on the validity of the Gottschalk-Gleser Anxiety Scales, the standard procedure for obtaining verbal samples was followed and self-report measurements of comparable emotional constructs were applied concurrently. Measures of state and trait emotions were administered to 25 female and 25 male university students. In the female group 18 significant convergent validity coefficients were found. For males, content analytic anxiety scores showed four significant correlations with concurrent self-report scales. These results suggest that content analytic anxiety scores from female subjects may allow a more accurate prediction of state and trait emotions than anxiety scores from male subjects. Thus, gender might have a differential effect on the validity of the Gottschalk-Gleser Anxiety Scales.

Adult↗
PubMed1998

Relations between neuropsychological vulnerability markers and negative symptoms in schizophrenia.

In neuropsychological vulnerability research the visual backward masking task, the Span of Apprehension, the degraded stimulus Continuous Performance Test (dsCPT), and the Wisconsin Card Sorting Test have been described as putative indicators for the predisposition to develop negative (schizophrenic) symptoms. The present study assesses the stability of the association between neuropsychological tests and negative symptoms by examining clinically improved patients. The interdependence between the four cognitive measures and clinical symptomatology was examined in 31 patients with DSM III-R and ICD-10 schizophrenia suffering predominantly from negative symptoms. Backward masking performance was related to affective flattening and anxiety-depression. False alarm rate on dsCPT was associated positively with affective flattening and hallucinations, and negatively with avolition. Card sorting preseverative errors correlated negatively with anhedonia, non-preservative errors correlated positively with avolition. Correlations notwithstanding, the data provide evidence in support of the relative independence of neuropsychological functions and negative symptoms in clinically improved schizophrenics.

Adult↗
PubMed1998

[Alexithymia and automatic activation of emotional-evaluative information].

The emotional valence of stimuli seems to be stored in the associative network and is automatically activated on the mere observation of a stimulus. A principal characteristic of alexithymia represents the difficulty to symbolize emotions verbally. The present study examines the relationship between the dimensions of the alexithymia construct and emotional priming effects in a word-word paradigma. The 20-Item Toronto Alexithymia Scale was administered to 32 subjects along with two word reading tasks as measures of emotional and semantic priming effects. The subscale "difficulty describing feelings" correlated as expected negatively with the negative inhibition effect. The subscale "externally oriented thinking" tended to correlate negatively with the negative facilitation effect. Thus, these dimensions of alexithymia are inversely related to the degree of automatic emotional priming. In summary, there is evidence for an impaired structural integration of emotion and language in persons with difficulties in describing feelings. Poor "symbolization" of emotions in alexithymia is discussed from a cognitive perspective.

Adult↗
PubMed1998

[Effectiveness of computer-assisted attention training of schizophrenic patients].

Recent years witnessed a considerable proliferation of computer-based training programmes as instruments of cognitive rehabilitation for schizophrenic patients. A study on the effects of a 3-week computer-based attention training with schizophrenic patients is presented. The Span of Apprehension and the Continuous Performance Test (CTP) were carried out before and after the training period. Performance improvements were found only on few attention training tasks. Schizophrenics had higher post-treatment hit rates on the Span of Apprehension, but no post-treatment improvements were observed in the CPT. Performance of trained patients in the external attention measures was not superior to performance of matched schizophrenic control patients. These data suggest that brief intensive computer-based attention remediation does not lead to enhanced attentional capacity in schizophrenia. Thus, it might be more adequate to teach behavioural strategies that bypass attention deficits or to offer programmes for exercising more complex cognitive skills than to try to remedy basic cognitive impairments.

Adult↗
PubMed1997

Paranoid schizophrenia: non-specificity of neuropsychological vulnerability markers.

During stages of remission, patients with paranoid schizophrenia seldom show severe attentional or information-processing dysfunctions, except in cases of long-term chronicity. The diagnostic specificity of four putative psychological vulnerability indicators of schizophrenia - the Span of Apprehension, the degraded stimulus Continuous Performance Test (dsCPT), the degraded stimulus visual backward masking task and the Wisconsin Card Sorting Test (WCST) - was examined in a group of patients with paranoid schizophrenia. Since no single test seems to identify all patients, the use of a combination of measures may be a useful strategy. Accordingly, the four tests were administered to 18 paranoid schizophrenic patients, 18 depressed patients and 18 normal subjects. Paranoid schizophrenic patients could be distinguished from normal subjects primarily on the basis of their performance on the backward masking task and secondarily by the dsCPT and the WCST. Paranoid schizophrenic and depressed patients could be differentiated to some extent by their performance on an information-mask condition of the backward masking task. Thus, of the four measures studied, only the degraded stimulus backward masking appeared to be a specific indicator of paranoid schizophrenia.

Adult↗
PubMed1996

[Disorders of early information processing and vigilance as vulnerability markers for schizophrenia].

Disordered processes of scanning iconic memory and vigilance deficits are well-known phenomena in schizophrenics. The "Span of Apprehension" and the "Continuous Performance Test" are among the most important research techniques assessing these impairments and are considered possible neuropsychological vulnerability markers of schizophrenia. Numerous studies compared schizophrenics with psychiatric control groups on these tasks to determine the specificity of the performance deficits which represents a central criterion for vulnerability markers. The review of the empirical results suggests a non-specificity of the performance of schizophrenics on the "Span of Apprehension" and the degraded stimulus version of the Continuous Performance Test. These findings are critically discussed with reference to the technical and methodological characteristics of the studies. Furthermore, studies are presented which examined the relationship of vigilance performance on the Continuous Performance Test and rate of detecting on "Span of Apprehension" and psychopathological symptoms with the aim to evaluate the marker qualities of these research techniques for schizophrenic symptoms. According to the available data a partial symptomatic specificity can be attributed to the "Span of Apprehension".

Attention↗
PubMed1984

Gene-splicing experiment.

In the article "Windows on a new cosmology" by George Lake (18 May, p. 675), the caption for figure 4(b) on page 680 was incorrect. The photograph shows the electric dipole moment apparatus at the Institute Laue-Langevin in Grenoble, France [courtesy of N. Ramsey].

DNA, Recombinant↗