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Biomedical subjects

T Sugihara

Publications and source records attributed to T Sugihara.

At least 253 records · Page 14Linked to original sources
PubMed1982

Myocardial ischemia and tooth extractions: comparison of old myocardial infarction, angina pectoris, and non-specific ischemic heart disease.

The non-specific IHD group showed the highest RPP values, while the angina pectoris group showed the lowest. The result coincided with electrocardiographic findings--non-specific IHD revealed 70% of ECG change, while in angina pectoris, the incidence was 33%. The myocardial infarction group showed intermediate values in both RPP and ECG change. The RPP ratio (RPP at each treatment period/value at pretreatment) was the highest at the anesthetic period for all kinds of IHD. No further severe findings were observed in the myocardial infarction groups, nor in the angina pectoris group, when comparing the clinical parameters, such as anesthetic solution, diazepam, time required for treatment, blood pressure, heart rate, and electrocardiographic observations with those of the non-specific IHD group.

Adult↗
PubMed1982

[Combination chemotherapy with neocarzinostatin (NCS) and other antitumor agents for advanced carcinoma of the digestive organs--improved clinical effect with NFO therapy].

We have previously reported the clinical effect of NF therapy (NCS 5,000 units and 5-FU 500 mg intravenously; twice a week) on patients with advanced carcinoma of the digestive system. In the present study, NFO therapy (NCS 2,000 units and 5-FU 500 mg intravenously, Picibanil 1-2K. E. intramuscularly; twice a week) was applied for those patients to take advantage over NF modality. Treated were 62 patients with NFO and 48 were evaluated for its clinical effects. In comparison of NFO and NF, the antitumor effects were noted in 9 of 48 patients (18.8%) for NFO, and 2 of 27 (7.4%) for NF therapy judged by Koyama & Saito's criterion. If the Karnofsky's criterion was applied, I-A category or more were obtained in 10 of 48 patients (20.8%) for NFO and in 2 of 27 (7.4%) for NF therapy. In particular, NFO therapy resulted in the advantageous clinical effects on patients with hepatic and pancreatic carcinomas irrespective of primary or metastatic. The adverse effects of NFO were not more frequent than those of NF therapy. From these results, a new combination regimen, NFO, is thought to bring about a considerable benefit in the treatment of advanced carcinoma of the digestive organs.

Adult↗
PubMed1978

Chronic intestinal bleeding due to arteriovenous malformation of the colon.

A case of chronic intestinal bleeding due to arteriovenous malformation of the ascending colon was reported. Vascular abnormalities of the bowel represent the most common cause of gastrointestinal bleeding, the source of which could not be dislosed by conventional diagnostic procedures; selective abdominal angiography is the only most reliable technique in such cases. An acquaintance with these conditions may be of importance in the search for the cause of intestinal hemorrhages of otherwise obscure origin, and more attention should be paid to the clinicopathologic features of this entity.

Arteriovenous Malformations↗
PubMed1976

Transmission and scanning electron microscopy of experimentally induced thyroid tumors in rats.

Irradiation of the neck region of 10 days old Wistar rats with 300 rads X-rays and their subsequent treatment with MTU leads to the development of thyroid tumors. The ultrastructure of the thyroid tumors induced was studied by transmission (TEM) and scanning electron microscopy (SEM). In follicular carcinomas, cylindrical or high columnar cells with abundant microvilli, well-developed ergastoplasmic reticulum and a hypertrophied Golgi complex predominate. The cytoplasm of the tumor cells of papillary carcinomas was composed of large pleomorphic cisternae, irregular in shape mitochondria, dense bodies, phagolysosomes and lamellar or multivesicular structures. Scanning electron microscopy revealed in the control animals a regular pattern of thyroid follicles tied to each other by tissue bridges and covered by set of blood and lymph vessels. The relief of the follicular carcinomas was irregular indicating follicles different in size and shape. The internal surface of the neoplastic follicles was also irregular as result of deep invaginations and intrafollicular cell growth. The apical region of the normal and neoplastic thyroid follicular cells was covered with abundant microvilli protruding into the colloid.

Adenocarcinoma↗
PubMed1975

Simulation of lung tissue properties in age and irreversible obstructive syndromes using an aldehyde.

Weak solutions of CHOH alter tissue properties, probably by forming intermolecular cross-linkages. The maximum length (Lmax) to which alveolar wall can be extended is reduced. If exposed to CHOH while extended, the resting length (LO) of alveolar wall increases. Maximum extensibility (Lambdamax equal to Lmax/LO) decreases. Similar changes are found in the alveolar wall of man with aging and are significantly more marked in patients with irreversible obstructive pulmonary syndromes. A reduction in the energy loss of the length-tension cycle (hysteresis) was seen after exposure to CHOH, however, that does not occur with age or in obstructive syndromes. Because an exposure of alveolar wall to elastase increases LO and hysteresis, we used a staged exposure to CHOH followed by elastase. Tissue suitably prepared by exposure to CHOH followed by elastolysis better simulates the tissue changes of age and irreversible obstructive syndromes.

Aging↗