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Biomedical subjects

T Storm

Publications and source records attributed to T Storm.

49 records · Page 3Linked to original sources
PubMed1985

Changes in vitamin D metabolites and bone histology in rats during recovery from rickets.

The relative roles of 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D) and 24,25-dihydroxyvitamin D (24,25-(OH)2D) in bone mineralization are largely unknown. Young vitamin D depleted rats were fed increasing amounts of vitamin D and grouped radiologically in accordance with the rat line test. They ranged from severely rachitic to normal. Radiology was correlated with serum levels of 25-OHD, 1,25-(OH)2D, 24,25-(OH)2D, ionized calcium, magnesium, and phosphate, with bone histology, and with the total mineral content of the animals. Serum 1,25-(OH)2D rose in a linear fashion to supranormal values during bone healing and correlated with the radiological degree of rickets. Serum 25-OHD was below detection limit in the most rachitic and low in the radiologically normal rats, whereas 24,25-(OH)2D was low in all groups. These two metabolites showed no correlation with the radiologic, histologic or biochemical parameters. In rachitic rats, 1,25-(OH)2D appears to play a major role in bone healing and possibly exerts a direct effect on bone cells. It cannot be ruled out, however, that the effect is mediated through a rise in serum levels of calcium and phosphorus, although signs of bone healing were seen in the presence of a subnormal calcium X phosphorus product. Initiation of mineralization can take place with unmeasurable 25-OHD, and 24,25-(OH)2D seems to be without importance.

Animals↗
PubMed1983

Variations in blood viscosity in patients with acute cardiogenic pulmonary oedema treated with frusemide.

In 10 patients with acute cardiogenic pulmonary oedema, treatment with large doses of intravenous frusemide (mean dose 156 mg) induced no signs of haemoconcentration. On the contrary, during an observation period of 2 h after start of treatment we registered a significant reduction of mean blood viscosity and mean haematocrit, indicating haemodilution. All the patients also received a basic treatment of intravenous pethidine and nasal oxygen and the conclusion is therefore that large doses of intravenous frusemide in treatment of acute cardiogenic pulmonary oedema can be given without risk of haemoconcentration when combined with intravenous pethidine and nasal oxygen.

Acute Disease↗
PubMed1975

Alcohol consumption and personal resources. A general hypothesis and some implications.

A general hypothesis is formulated in which alcohol consumption is largely determined by the resources available for drinking, the activities competing for those resources, and the costs associated with drinking in the context of a particular social status. Implications in terms of drinking patterns of occupational subgroups, longitudinal changes in alcohol consumption, and vulnerability to the development of pathological drinking are suggested.

Age Factors↗
PubMedDate not supplied

Use of ceftazidime-impregnated polymethyl methacrylate beads in the treatment of Pseudomonas osteomyelitis.

Antibiotic-impregnated polymethyl methacrylate beads have been used in other countries to treat osteomyelitis. The drug of choice for this has historically been gentamicin. The authors have chosen ceftazidime to treat iatrogenic Pseudomonas aeruginosa osteomyelitis in rabbit femurs. After implanting the beads, the rabbits were killed at various times in the treatment period. Rabbits were killed at 15 days and later showed no signs of current osteomyelitis, including cultures and histologic examination. Blood antibiotic levels were measured at euthanasia and were minimal for all animals. It appears that ceftazidime may be an effective alternative to gentamicin, especially in treating gentamicin-resistant P. aeruginosa.

Animals↗