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Biomedical subjects

T Stone

Publications and source records attributed to T Stone.

28 records · Page 2Linked to original sources
PubMed1991

Enhanced chemiluminescence for the detection of membrane-bound nucleic acid sequences: advantages of the Amersham system.

A range of nonradioactive nucleic acid labeling and detection systems have been developed that enable the user to label probes directly with enzyme molecules or indirectly with hapten-derivatized nucleotides. Horseradish peroxidase is used for the direct labeling procedures due to the ease of chemical modification and the relative thermal and chemical stability of this enzyme. Horseradish peroxidase has also been conjugated to a high-specificity antifluorescein antibody for detection of hapten (fluorescein)-labeled hybrids. Enhanced chemiluminescence is a light-emitting process optimized for the detection of low levels of horseradish peroxidase on membrane supports. Results are obtained as hard copy images on x-ray film.

Base Composition↗
PubMed1987

Standardized endosonographic evaluation of prostate cancer: receiver-operator-characteristic analysis.

A standardized endosonographic numeric method has been developed for the detection of prostate cancer. Eighty-six men were examined with a 5-MHz, 96-element linear-array probe. Mean gray-scale amplitudes were produced by a semiautomatic method for periprostatic fat and regions of interest within the external portion of the prostate gland that were visually suspicious for prostate cancer. Mean gray-scale amplitude ratios of visually abnormal areas of prostate to periprostatic fat (Ap/Af) were calculated. Pathologic confirmation of disease was obtained in all patients. Three different numeric Ap/Af ratios were compared with digital palpation and subjective visual interpretation of sonograms. The numeric method resulted in a consistently higher specificity, accuracy, and positive predictive value when compared with palpation and subjective interpretation. The initial results suggest that this technique may also detect atypical hyperplasia.

Adenocarcinoma↗
PubMed1985

Retroperitoneal fibrosis with normal intravenous urogram.

A 58 year old male presented with a two week history of low back pain and malaise. The intravenous urogram (IVU) at presentation was normal but within three months he had developed renal failure with bilateral ureteric obstruction on repeat IVU. Primary retroperitoneal fibrosis was confirmed at operation. This case demonstrates that retroperitoneal fibrosis may progress rapidly to renal failure within a few months of the first symptoms. In addition, the IVU may be normal in the early stages of the illness.

Acute Kidney Injury↗
PubMed1984

Endemic goitre, nutrition, and landholding in Bangladesh.

Endemic goitre in adult females, cretinism, and anthropometry in children were examined in a goitrous area of Bangladesh. An area survey showed total goitre varying from 62.0 to 93.0%, visible goitre from 9.0 to 54.8% between areas. A village study examining thyroid size in 538 adult females and anthropometry in 116 children showed goitre prevalences varying significantly (p less than 0.001) but unpredictably with household landholding size; underweight and wasting varied inversely and significantly (p less than 0.01 and 0.05 respectively) with the same socioeconomic indicator. By household, there was no relationship between anthropometry in children and thyroid enlargement in the mother. Hormone analyses showed depressed serum T4, but no raised TSH. Only one deaf-mute cretin was found in the area. It is speculated that variation in goitre prevalence in this moderately severe endemic primarily reflects qualitative and quantitative changes in diet, as a function of the socioeconomic status of the household.

Adolescent↗
PubMedDate not supplied

Impact of research on pediatric pain assessment and outcomes.

PURPOSE: Pediatric nurses from varied practice and educational backgrounds learned about research by doing a ward-based study. The aim of the study was to determine if regular assessment of children's pain would improve their pain management and postoperative progress. METHOD: Children, ages 5 to 17 years (n = 36), measured their pain every 4 hours postoperatively using the Wong-Baker Faces Pain Rating Scale. Outcomes regarding amount of analgesic given, subjective pain reports, time and progress of ambulation, and length of hospital stay were compared with data from a retrospective chart-review of a control group (n = 50). FINDINGS: No statistically significant differences in these variables were found. An important clinical finding was that despite all children having prescribed PRN analgesic orders, one quarter of the children received no pain relief intervention. Also, one quarter of the children stated that their pain control was only partially effective. CONCLUSIONS: Study results reinforce findings reported in the literature regarding ineffective pain management in children, and highlight a need for improved nursing practice. Clinical significance was achieved in terms of staff learning of the research process, increased awareness of pediatric pain management practices, improved ward morale, and inter-agency sharing of resources.

Adolescent↗