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Biomedical subjects

T Srichaikul

Publications and source records attributed to T Srichaikul.

At least 37 records · Page 2Linked to original sources
PubMed1979

Acute massive intravascular hemolysis and disseminated intravascular coagulation.

Two cases of acute intravascular hemolysis complicating acute disseminated intravascular coagulation were presented, one after normal delivery and the other after group A beta hemolytic streptococcal septicemia complicating acute myelomonoblastic leukemia. Neither case received heparin therapy. The first one survived while the latter succumbed. Intravascular hemolysis may not be a bad prognostic sign in such a condition.

Adult↗
PubMed1977

Fibrinogen metabolism and disseminated intravascular coagulation in dengue hemorrhagic fever.

In 29 patients with dengue hemorrhagic fever (DHF), 12 with grade 2 and 17 with grades 3 and 4, fibrinogen metabolism was studied by using 125I-fibrinogen; 11 of these patients were studied during shock. Hemostatic studies were also performed to search for evidence of disseminated intravascular coagulation (DIC). Increased intravascular coagulation, as judged by rapid T1/2 of 125I-fibrinogen, as well as evidence of DIC by hemostatic patients with DHF grade 2 had rapid T1/2 and only 17% had DIC. Of the 11 patients studied during shock, 91% had both rapid T1/2 and evidence of DIC, whereas 63% of the 18 patients without shock had rapid T1/2 and only 11% of this latter group had DIC. A correlation between the increased fibrinogen consumption as judged by rapid T1/2 of 125I-fibrinogen, DIC, clinical severity, and shock was demonstrated. The role of DIC in the pathogenesis of DHF is discussed, and heparin is suggested for patients with prolonged shock and severe acidosis when DIC becomes clinically apparent.

Adolescent↗
PubMed1976

Histamine changes in Plasmodium falciparum malaria.

Histamine, serum complement factor 3 (C'3) and platelets were studied in 33 Plasmodium falciparum patients. Elevation of histamine level in the blood was found during acute infection but was more marked in the group of patients with systemic complications. A correlation between histamine changes, clinical complications, reduction of C'3 and degree of thrombocytopenia was observed. The possible role of histamine in the development of complications in P. falciparum infection and the possible release of this substance through the activation of complement system and immune destruction of platelets were discussed.

Adult↗
PubMed1976

Ferrokinetics in patients with malaria: haemoglobin synthesis and normoblasts in vitro.

Bone marrow cultures in 15 Plasmodium falciparum patients were studied both during and after parasitaemia. Abnormalities were observed only in the group during parasitaemia. These abnormalities included: (1) decreased normoblastic number and cellular iron incorporation in all cases; (2) premature death of normoblasts during their development in the cultures in all cases; (3) defective haemoglobin synthesis in 3 of 11 cases (27%). A causal relationship between defective haemoglobin synthesis and degree of normoblastic destruction in the cultures was found. Marked anaemia and depressed C'3 level were found only in the group with defective haemoglobin synthesis. The significance of these findings is discussed.

Adolescent↗
PubMed1975

Complement changes and disseminated intravascular coagulation in Plasmodium falciparum malaria.

Complement activation as shown by increased clearance of radioactive C1q and reduction in serum-C3 level was found in fifteen (83%) of eighteen patients studied during Plasmodium falciparum infection. Six patients had haemostatic defects suggesting disseminated intravascular coagulation (D.I.C.), and five others had other clinical complications. A correlation was found between reduction of C3 and clinical complications as well as with the degree of anaemia and with thrombocytopenia. Moreover, the most severe thrombocytopenia and the most severe reduction of C3 levels were found in those patients with D.I.C. An immune reaction associated with complement activation in P. falciparum infection is believed to contribute to injury of red blood-cells and platelets and to promote the development of D.I.C. and other serious clinical complications.

Adolescent↗