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Biomedical subjects

T Sone

Publications and source records attributed to T Sone.

At least 235 records · Page 13Linked to original sources
PubMed1982

Clinical effectiveness of niludipine in patients with ischemic heart disease.

The antianginal efficacy of niludipine (Bay a 7167), a new calcium antagonistic drug, was investigated in 51 patients with ischemic heart disease. 16 patients were diagnosed as effort angina and 31 patients had both angina at rest and on effort. Six anginal patients had myocardial infarction. One patient was diagnosed as a variant form of angina and 3 others as unstable angina. 11 patients had essential hypertension. 49 completed the study and 2 dropped out. Niludipine (60 mg to 80 mg every 24 h) significantly reduced the mean weekly rate of angina attacks from 6.5 to 2.2 (p less than 0.001). Marked reductions of nitroglycerin requirement were also noted (p less than 0.001). In 71% of the patients complete control of anginal attacks was achieved, and in over 77% the frequency of angina was reduced by at least 50%. Niludipine was at 93.8% effective in patients with ischemic heart disease. It decreased significantly both systolic and diastolic blood pressure in angina patients with essential hypertension, but there were no significant changes of blood pressure in normotensive anginal patients. The agent was tolerated very well and there were no side effects. These findings suggest that niludipine is a highly effective drug for the treatment of both ischemic heart disease and essential hypertension.

Adult↗
PubMed1981

A study on the noninvasive evaluation of coronary vasodilating drugs with Thallium-201 myocardial imagings.

To evaluate clinically the effects of coronary vasodilating drugs, isosorbide dinitrate (ISDN), dilazep (DL), and dipyridamole (DP), on the myocardial perfusion, quantitative analysis of Thallium-201 myocardial imagings was performed before and after their sublingual or oral administration in 17 patients with ischemic heart disease (IHD) and 9 normal volunteers. The ratio of total myocardial blood flow to cardiac output (TMBF/CO) and the ratio of ischemic regional myocardial blood flow to cardiac output(RMBF/CO) were calculated according to the indicator fractionation principle. The ratio of radio-activity of infarcted region to total myocardium (R/T) was also calculated to judge the degree of scintigraphic defect objectively. There were increases in TMBF/CO in 7 of 9 patients after ISDN, 4 of 5 patients after DL, and 2 of 6 patients after DP. Increases in RMBF/CO were observed in all patients studied after ISDN and DL, whereas in 2 of 6 patients after dipyridamole. Decreases both in RMBF/CO and R/T which suggest coronary steal phenomenon were observed in 4 of 6 patients after DP. The myocardial imaging technic is a useful noninvasive method for clinical evaluation of coronary vasodilating drug.

Adult↗
PubMed1980

Formation, deoxygenation and mutagenicity of alpha-hydroperoxydialkylnitrosamines.

N-Nitroso-N-alkyl-alpha-hydroperoxyalkylamines were prepared either by treatment of N-nitroso-N-alkyl-alpha-acetoxyalkylamines with hydrogen peroxide in acetic acid or by oxygenation of lithiated N-nitrosodialkylamines with oxygen. They were strongly mutagenic towards S. typhimurium TA1535 and E. coli WP2 strains without metabolic activation. Treatment of the alpha-hydroperoxy compounds with deoxygenating agents, such as sodium bisulfite, gave the alpha-hydroxynitrosamine, which could be isolated in aprotic solvents and characterized. The alpha-hydroperoxy compounds can possibly be formed from N-nitrosodialkylamines by biochemical and environmental routes and can serve as precursors for the alpha-hydroxynitrosamines.

Chemical Phenomena↗
PubMed1975

[Effect of intermittent noise on the function of concentration maintenance (TAF) and the brain waves (author's transl)].

The effect of three different kinds of noise, having equal physical energy but different psychological load, was examined by the TAF-test and the brain waves. Thirty nine healthy male subjects aging from 19 to 34 were exposed to white noise of 80 dB (C) under the following three conditions: (1) continuous noise for ten minutes, (2) regular intermittent noise, consisted of one-minute noise and one-minute rest, for 19 minutes, and (3) irregular intermittent noise, consisted of one-minute noise and irregular rest period, for 19 minutes. In each condition, the duration of noise-exposure totals ten minutes. Before, during and after the noise-exposure, the TAF-test was given to the 23 subjects out of 39, and the brain waves were recorded from the rest 16 subjects. The changes of TAF-L and alpha wave appearance were compared. The results obtained were as follows. 1. All three kinds of noise-exposure caused significant lowering of the function of concentration maintenance, especially in the latter half period of the noise administration. 2 Lowering of the function of concentration maintenance due to the irregular intermittent noise-exposure was greater than that due to the regular intermittent noise-exposure. 3. As to the continuous noise-exposure, appearance of the alpha wave decreased significantly in the 9th to 10th minute of noise administration and in the 1st min. after the exposure, while it increased in the 18th to 22nd min. after the exposure. 4. Exposure to the regular intermittent noise resulted in a significant decrease of the alpha wave appearance at the latter half of the noise administration, which continued after the exposure. 5. Exposure to the irregular intermittent noise caused a significant decrease of the alpha wave appearance after the middle period of noise administration. 6. Comparing the regular intermittent noise and irregular one, the latter brought about stronger alpha-blocking during the noise administration, but earlier restoration after the exposure. These results indicate that the influences of noise as a stressor differ not only by the amount of its physical energy but also by the condition of its generation, and that the differences of on-off effect on the brain activities based on regular or irregular intermittent noise were grasped by the changes of the function of concentration maintenance and the alpha wave appearance.

Adult↗