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Biomedical subjects

T Soma

Publications and source records attributed to T Soma.

At least 109 records · Page 6Linked to original sources
PubMed1984

Pressure gradient and blood flow in human arm veins--a proposed explanation of the pumping mechanism.

In a patient with mitral stenosis we previously found a negative periphero -central pressure gradient (P-C PG) despite a forward peripheral venous blood flow velocity ( PVBFV ) during supine leg exercise. The present study was undertaken to confirm this finding and elucidate its mechanism. In 6 patients with congestive heart failure, P-C PG was reversed from -2.4 to -18.7 cm H2O for 1 to 5 minutes during exercise. PVBFV , measured simultaneously with peripheral venous pressure (Pv) in 8 subjects, remained positive; 5 of these were patients with a negative P-C PG. The effect of intravenous lidocaine(1-26 mg) was studied in 13 patients: In 4 of 13 patients the change in Pv by saline injection was smaller than that after lidocaine (2-5 mg) injection (-0.5 +/- 0.5, 3.9 +/- 0.8 cm H2O, mean +/- SE, respectively) (p less than 0.02). In 13 patients Pv rose after a small dose of lidocaine. After a larger dose the rate of rise of Pv decreased or Pv dropped. No significant change was observed in the central venous pressure. In 6 patients who performed Valsalva's maneuver, the rate of rise of Pv during the test decreased or unchanged after lidocaine injection. The probability of a pumping mechanism in superficial human arm veins was discussed.

Adult↗
PubMed1984

[The effects of preoperative irradiation therapy in advanced stomach cancer].

Over the past 20 years the survival rate for advanced stomach cancer among Japanese remains the same. In order to increase the survival rate, 17 years ago we initiated a type of preoperative irradiation therapy as an adjunct to surgery. We have tried to develop an adequate plan for indication of preoperative irradiation. The results obtained were as follows. 1. In this study we used a computer simulated method which aided in determining a suitable plan for adjunct irradiation therapy. 2. The adequate total dosage ranged 3,000 +/- 1,000 rads, with a 2 weeks waiting period between irradiation treatment and surgery, especially for advanced gastric cancer invading to ss and up to 6 cm in diameter. 3. Histopathological findings from resected specimen, using pH 4.1 TBM staining method, indicated decrease in the depth of the carcinoma and extent and size of the tumor as well as degeneration and/or disappearance of the cancer cells due to the preoperative therapy. 4. We identified the decrease of metastatic rates of the regional lymphnodes in the irradiation group. 5. Clinical results indicated an improved resectability rate of 6.1% and an approximate 12.1% increase in the 5 years survival rate.

Combined Modality Therapy↗
PubMed1984

[Angiomyolipoma of the kidney: report of three cases and a statistical study of 194 cases in Japan].

Three cases of renal angiomyolipoma are reported. The first case was a 53-year-old female with the complaint of left flank pain. In both cases selective angiography revealed a renal tumor, and computerized tomography disclosed a renal mass with low density corresponding to the fat tissue. From several examinations these two cases were preoperatively diagnosed as renal angiomyolipoma and nephrectomy was performed. Histopathological diagnosis was renal angiomyolipoma. The third case was a 64-year-old female with the complaints of left flank pain and macrohematuria. In this case computerized tomography revealed a renal mass which did not have a low density area. The possibility of renal cell carcinoma was considered and nephrectomy was performed. Histological diagnosis was renal angiomyolipoma which was primarily composed of smooth muscle cells. The first case had a calcified lesion in the brain. But there was no evidence of tuberous sclerosis in the following two cases. Some problems in diagnosis and treatment of renal angiomyolipoma are presented, and a statistical study is made on 194 reported cases of renal angiomyolipoma in Japan.

Female↗
PubMed1982

Effect of post-ovulatory age of recipient on survival of frozen-thawed rabbit morulae.

A significantly higher survival rate was obtained when frozen-thawed morulae were transferred to oviducts of recipients ovulating after donors rather than to those of synchronized or earlier ovulating recipients. The highest proportion of live young, 23%, was obtained after transfer of eggs to recipients ovulating 18 h after donors. The proportion of live young (48%) was significantly increased when frozen-thawed rabbit morulae were transferred into both oviducts of recipients at this stage.

Animals↗
PubMed1980

A serious problem of the heated thermocouple flowmeter.

In the measurement of regional blood flow with heated thermocouple flowmeter, we frequently observed puzzling phenomenon that the measured values were augmented while the flow was actually diminished and vice versa (Inversion). "Inversion" was directly attrebutable to the structure of the thermocouple probe. A countermeasure against "Inversion" was found to lie in the arrangement of the hot junction in the center of the heater, and in practical application, it must be checked by stopping the flow at each measurement. Overcoming this technical liability should pave the way for a marked improvement in the reliability of this method which, despite possessing many excellent characteristics for determining regional blood flow, is not widely used.

Animals↗
PubMed1975

Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man.

Studies on peripheral metabolism of simultaneously administered 125-I-labeled L-thyroxine ([125-I]T4) and 131-I labeled L-trilodothyronine ([131-I]T3) were performed in five normal subjects, in four patients with untreated hypothyroidism, and in 3 hypothyroid patients made euthyroid by the administration of T4. The fractional turnover rate (lambda 03) of thyroid hormones irreversibly leaving the site of degradation and the volumes of pool 1 (serum V1) of pool (interstitial fluid, V2), and of pool 3 (all tissues, V3)were obtained by using a three-compartment analysis. In addition to the turnover studies, the ratios for the in vivo T4 to T3 conversion were determined by paper chromatographic study in sera obtained 4, 7, and 10 daysafter the injection. The rate (K12) of the extrathyroidal conversion of T4 to T3 was also estimated by the compartment analysis. The T3 distribution volume (V3) of pool 3, in which T3 is utilized and degraded, was about 60% of totaldistribution volume (V=V1+V2+V3) in normal subjects, whereas only about 25% of the extrathyroidal T4 pool was in the intracellular compartment, indicating that T3 is predominantly an intracellular hormone..

Adult↗
PubMed1975

Measurement of venous blood flow and pressure using thermoelectric and pressure transducers.

In order to simplify procedures for testing the circulatory function of a patient, changes in the venous blood flow as well as venous pressure following exercise were continuously observed using the thermoelectric flowmeter. The level of zero flow necessary for evaluation of the velocity of flow was successfully indicated without occlusion of blood vessels by means of a form of compensation for thermal diffusion devised by the authors.

Blood Flow Velocity↗