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Biomedical subjects

T Solakivi-Jaakkola

Publications and source records attributed to T Solakivi-Jaakkola.

9 recordsLinked to original sources
PubMed1986

Fatty acid composition of serum cholesteryl esters in relation to serum lipids and apolipoproteins in 3-18-year-old Finnish children and adolescents.

Serum cholesteryl ester (CE) fatty acids, serum lipids and apolipoproteins were analysed from 1348 Finnish children aged from 3 to 18 years. The study was part of a comprehensive survey of coronary heart disease risk factors and their determinants in Finnish children and adolescents. The percentage of CE linoleate (18:2) had significant negative correlations with the serum concentrations of total and LDL cholesterol, triglycerides as well as apo B. The associations of HDL to CE fatty acids were weak, although there was a significant positive correlation of CE-18:2 to HDL cholesterol and apo A-I. The ratio of HDL to total cholesterol and the ratio of apo A-I to apo B increased strongly in quintiles of increasing percentage of CE-18:2. In conclusion, the present results show significant associations between serum CE fatty acid composition and the different components of serum lipoproteins among free-living Finnish children and imply a relation between the quality of dietary fats and serum lipoproteins within this population.

Adolescent↗
PubMed1986

One-year follow-up of lipoprotein metabolism after pregnancy.

Serum lipid and lipoprotein fractions one day after delivery, 3 months later in lactating and nonlactating mothers and 12 months later after initiation of menstruation were investigated in a group of 62 women, 29 of which formed a truly longitudinal group. Total serum cholesterol decreased significantly within 3 months after delivery and a further significant decrease occurred during the following 9 months. LDL- and HDL-cholesterols showed also a significant decrease within the postpartal year. Serum triglycerides decreased within 3 months after delivery but no more significantly later. Apolipoprotein AI and B also decreased within 3 months after delivery. In lactating mothers, HDL-cholesterol: cholesterol ratio, apolipoprotein AI and apolipoprotein AI:B ratio were higher than in nonlactating women. During the luteal phase, serum cholesterol and LDL-cholesterol were lower and the HDL-cholesterol: cholesterol ratio was higher than earlier during the menstrual cycle. Data prove that pregnancy related changes in lipid metabolism did not wane within 3 months after delivery. They also show that lactation affects lipid metabolism.

Adolescent↗
PubMed1985

Atherosclerosis precursors in Finnish children and adolescents. II. Height, weight, body mass index, and skinfolds, and their correlation to metabolic variables.

In a Finnish Multicentre Study, height, weight and skinfold thicknesses were measured in 3-, 6-, 9-, 12-, 15-, and 18-year-old children (N = 3,596). Height and weight percentiles superimposed on the current Finnish growth charts were above the standards in 6-15-year-old boys and 3-12-year-old girls. Triceps skinfold thickness percentiles (10% and 90%) appeared to be closest to British values and below American values. Weight, body mass index (BMI) and skinfold thicknesses showed good intercorrelations (up to .90) except in young boys. Height had a low positive correlation with BMI (.28 to .36) and with skinfold thickness (.23 to .36) in the age groups 6-12 years. BMI and subscapular skinfold seem to be useful obesity indicators. No consistent correlations were seen between physical variables and serum LDL- or total cholesterol and apoprotein B concentrations. There was a slight negative correlation between the physical variables and serum HDL-cholesterol. Apoprotein A1 correlated negatively to all obesity indicators in 12-year-old girls. Serum triglycerides showed slight positive correlation to physical variables. BMI and skinfolds had a low to moderate correlation with insulin (.21-.51) mainly in the three oldest age groups. On the ground of BMI and skinfold measurements we have reason to believe that the prevalence of obesity at 3-18 years of age is similar in Finland as in other countries in Europe.

Adolescent↗
PubMed1985

Atherosclerosis precursors in Finnish children and adolescents. VI. Serum apolipoproteins A-I and B.

The concentrations of apolipoproteins A-I and B were determined in 1,341 3- to 18-year-old children and adolescents from five urban and 12 rural communities. The analyses were made with radial immunodiffusion. The mean concentrations (+/- S.D.) of apo A-I and apo B were 152 +/- 25 and 94 +/- 22 mg/100 ml, respectively. 3-year-old children had the highest apo B levels which then decreased with advancing age in both sexes. Boys tended to have lower levels of apo B than girls. Apo A-I concentration was significantly higher in the 9- and 12-year-old boys than in the other age groups but showed no age-bound trend in girls. The apo A-I to apo B ratio increased with age in both sexes. The concentration of apo A-I was significantly lower, and that of apo B higher, in children living in eastern Finland in comparison with those from the western part of the country. This difference and a higher HDL-cholesterol to apo A-I ratio in both sexes in eastern Finland may be associated with the regional differences in the prevalence of coronary heart disease in this country.

Adolescent↗
PubMed1983

Effect of furosemide on the lipid abnormalities in chronic renal failure.

The effect of furosemide on the lipoprotein profile and the activities of postherapin plasma lipases were studied in 12 patients with chronic renal failure. The concentrations of serum total, VLDL and LDL triglycerides were significantly higher and the concentration of HDL triglyceride was significantly lower in the patients with renal failure than in healthy controls. HDL cholesterol was significantly lower in the patients than in the controls. The activity of postherapin lipoprotein lipase was significantly lower in the patients than in the controls. The introduction of furosemide induced a significant increase in the concentrations of VLDL cholesterol and VLDL triglyceride. These changes were reversed when the drug treatment was discontinued. Postherapin lipase activities were not further altered by furosemide.

Adult↗
PubMed1982

Effect of procetofen on apolipoprotein A I and B concentrations in hyperlipoproteinemia.

Thirty-three hyperlipoproteinemic patients were subjected to therapy with procetofen (300-600 mg daily) for 6 months in a placebo-controlled study. Lipoprotein changes based on cholesterol fractions have been reported previously. This report shows that procetofen increase Apo A I only slightly. Apoprotein B decreased by 16% and the ratio of Apo A I to Apo B was increased by 31%. In addition, procetofen induces changes in HDL composition: the relative amount of cholesterol is increased, which may reflect more efficient efflux of cholesterol from the tissues.

Adult↗
PubMed1979

Plasma lipids and lipoproteins in Down's syndrome.

Since mongoloids have been reported to differ from other patients with mental retardation by being virtually free of atheromatosis, we analysed plasma lipids and lipoproteins in twenty mongoloid and in twenty age-matched non-mongoloid mentally retarded patients living in the same institution. Plasma total cholesterol in the mongoloids did not differ significantly from that of the control group, but it was low in both groups in comparison with the Finnish population in general. Plasma total triglyceride concentration was higher (P less than 0.01) in the mongoloids than in the controls. This was reflected in higher VLDL-triglyceride and-cholesterol concentrations in the mongoloids. Plasma apolipoprotein B levels were higher (P less than 0.05) and the ratio of apolipoprotein A-1 to apolipoprotein B was lower (less than 0.05) in the mongoloids. The plasma lipid concentrations were in accordance with the significantly higher relative body weights in the mongoloid group. Blood pressure was slightly but significantly lower and cigarette smoking was less common in patients with Down's syndrome. Our results did not explain the reported lower frequency of atheromatosis in Down's syndrome.

Adolescent↗
PubMedDate not supplied

Fenfluramine therapy in non-insulin-dependent diabetic patients: effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism.

The usefulness of fenfluramine (F), in association with diet therapy, was investigated in 13 obese non-insulin-dependent diabetic patients with poor diabetes control on a previous sulfonylurea regimen (SU). A double-blind crossover comparison of F and placebo (P) consisted of two 7-wk treatment periods. F was administered in stepwise increased and subsequently reduced doses, while the doses of SU were kept unchanged. There was a significant weight loss in F-treated obese subjects as compared with treatment by P. The fasting levels, and particularly the postprandial blood glucose (BG) levels, were significantly lower during F than during P administration. Serum fasting insulin and blood lactate concentrations remained unchanged during the trial. Serum triglycerides and cholesterol decreased during F administration. HDL-cholesterol and apoprotein A-I increased slightly, while apoprotein B decreased during F, but not during P administration. The effect of fenfluramine on hepatic drug metabolism was assessed by using the antipyrine test. F did not cause significant changes in antipyrine metabolism. Fenfluramine therefore seems to be useful as an adjunct to diet and SU therapy in obese non-insulin-dependent diabetic patients.

Adult↗