Search PubMed⌕ Search

Biomedical subjects

T Smith

Publications and source records attributed to T Smith.

At least 685 records · Page 38Linked to original sources
PubMed1986

AIDS, them, and us.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1986

The evaluation of choanal atresia by computed tomography.

The radiographic evaluation of choanal atresia has traditionally consisted of a nasopharyngeal contrast study, however, this procedure has certain diagnostic limitations. The contrast nasopharyngogram does not define the type or thickness of the atresia. Computed tomography (CT) accurately characterizes the nature and thickness of the atresia, and visualizes the associated thickening of the vomer and narrowing of the posterior nasal cavity. CT evaluation with three dimensional reconstruction adds an additional diagnostic dimension. Seven patients have been evaluated by CT. The results show CT is a cost effective method to clearly define the abnormal anatomy. CT is the radiographic procedure of choice in the evaluation of choanal atresia.

Airway Obstruction↗
PubMed1986

Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen.

The monoclonal anti-idiotypic antibody (mAb2) 87.92.6 directed against the 9B.G5 antibody specific for the virus neutralizing epitope on the mammalian reovirus type 3 hemagglutinin was previously demonstrated to express an internal image of the receptor binding epitope of the reovirus type 3. Furthermore, this mAb2 has autoimmune reactivity to the cell surface receptor of the reovirus. The nucleotide and deduced amino acid sequences of the 87.92.6 mAb2 heavy and light chains are described in this report. The sequence analysis reveals that the same heavy chain variable and joining (VH and JH) gene segments are used by the 87.92.6 anti-idiotypic mAb2 and by the dominant idiotypes of the BALB/c anti-GAT (cGAT) and anti-NP (NPa) responses. [GAT; random polymer that is 60% glutamic acid, 30% alanine, and 10% tyrosine. NP; (4-hydroxy-3-nitrophenyl)-acetyl.] Despite extensive homology at the level of the heavy chain variable regions, the NPa positive BALB/c anti-NP monoclonal antibody 17.2.25 binds neither 9B.G5 nor the cellular receptor for the hemagglutinin. Amino acid sequence comparison between the viral hemagglutinin and the 87.92.6 mAb2 light chain "internal image," reveals an area of significant homology indicating that antigen mimicry by antibodies may be achieved by sharing primary structure.

Amino Acid Sequence↗
PubMed1986

Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.

Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h. Although a statistically significant increase in patients by comparison with controls could be demonstrated, wide variations in specific activity of the ligand preclude a firm conclusion. In two patients but no controls an asymmetry in striatal uptake was noted, the uptake on the left being less than that on the right.

Adult↗
PubMed1986

Clinical and electrophysiological recovery from peroneal palsy.

Clinical examination, electromyography and conduction studies in motor and sensory fibres were performed in 14 patients with peroneal palsy of compressive or spontaneous origin. After a period of from 5 months - 3 years, the clinical and electrophysiological examinations were repeated. The rate of recovery was not uniformly good, as only 6 of 14 patients had a complete clinical recovery. Most patients had an incomplete electrophysiological recovery which only partly corresponded to the clinical findings. Electromyography and conduction studies in sensory and motor fibres were found to be of value in predicting the outcome of the peroneal palsy.

Adult↗
PubMed1986

Evoked potentials in multiple sclerosis before and after high-dose methylprednisolone infusion.

We studied 8 patients with definite multiple sclerosis (3 with acute relapse, 5 with progression), and 2 patients with acute optic neuritis, who were treated with methylprednisolone infusions, 1 g daily for 3 days. Visual, brain stem-auditory and somatosensory-evoked potentials were used to test the effect of therapy. There were no manifest changes of the evoked potentials parameters parallel to the clinical effect of high-dose therapy.

Adult↗
PubMed1986

Motor neuron disease and plasma cell dyscrasia.

In the years 1977 to 1984, 10 of 206 patients (4.8%) with motor neuron disease (MND) had M proteins; 4 had IgM and 6 had IgG. Among 100 control patients with other neurologic diseases, only 1 had an M protein. We later added six cases of MND and M proteins, as well as three with polyclonal IgM elevations and two with Bence-Jones proteins. Including other reports, there are now 37 known cases of MND with monoclonal and 5 with polyclonal gammopathy. There is evidence that plasma cell dyscrasia is often undetected; the actual incidence of serum immunoglobulin abnormality in patients with MND may be greater than our figure.

Adolescent↗
PubMed1986

The long-term hazards of the treatment of thyroid cancer with radioiodine.

Two-hundred and fifty-eight patients treated with high-activity 131I for thyroid cancer and on prolonged follow-up have been reviewed to determine long-term hazards and their relation to the radiation dose received. The expectation of life of those dying from causes other than cancer was slightly reduced in the female patients. A small, significant excess of deaths from cancer of the bladder and from leukaemia was found which, assuming that these were due to radiation, gave inferred risk-rates respectively of 0.4 and 4.9 deaths per 10(4) PYG (patient-year-grays) to the bladder wall and red marrow. Of 31 younger patients (eight male, 23 female), four of the marriages have been infertile. The fertile marriages produced a total of 44 live births. Considerable gonad irradiation (estimated 0.8-2.7 Gy) was compatible with apparently normal fertility. Despite the high level of irradiation of the salivary glands, no malignancies and only one adenoma was found. Impaired pulmonary function occurred in only one of the patients who had diffuse bilateral metastases. In this patient, tumour in the lung was persistent throughout, so that radiation was probably not alone responsible.

Abdominal Neoplasms↗
PubMed1986

Imaging the pediatric liver: MRI and CT.

The livers of 27 children, 2 weeks to 16 years old, were examined with MRI and CT. Fourteen children had normal livers, 9 had focal liver disease, and 4 had diffuse liver disease. Normal intrahepatic venous anatomy was visualized more frequently with MRI than with CT, regardless of presence of disease, type of disease, or age. Focal hepatic lesions were either iso- or hypointense on relatively T1-weighted images and were hyperintense on T2-weighted images regardless of the pathology. In three cases, lesions seen with MRI were not detected with CT. In two other cases, CT was interpreted as equivocal or abnormal, but the liver was normal on MRI. MRI was superior to CT for evaluation of patency of the intrahepatic portion of the inferior vena cava. Other than in cases of fatty infiltration, CT provided no information additional to MRI. MRI has the potential to replace CT as a technique for imaging the pediatric liver in many cases, especially for infants and young children.

Adolescent↗