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Biomedical subjects

T Shioiri

Publications and source records attributed to T Shioiri.

At least 91 records · Page 5Linked to original sources
PubMed1987

Chloropolysporins A, B and C, novel glycopeptide antibiotics from Faenia interjecta sp. nov. IV. Partially deglycosylated derivatives.

Chloropolysporins A, B and C, new members of the glycopeptide antibiotic family, were enzymatically and chemically converted to their partially deglycosylated derivatives. The alpha- and beta-avoparcins were also deglycosylated by the same method. The conversions were achieved by treatments with rhamnosidase (Naringinase) and alpha-mannosidase, and by mild acid hydrolysis.

Anti-Bacterial Agents↗
PubMed1985

Antihepatotoxic actions of gingerols and diarylheptanoids.

The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods. The carbon tetrachloride assay appeared to be most useful in defining structure-activity relationships. The antihepatotoxic activity of gingerols and shogaols was dependent on the length of the side chain with the [7]- and [8]-companions eliciting the strongest activity. The gingerols exerted more intense activity than the corresponding shogaols. In the diarylheptanoids, introduction of hydroxyl groupings on the phenyl rings caused increased activity; however, the effect of the positions and number of hydroxyls on activity was variable depending on the carbon skeleton.

Alanine Transaminase↗
PubMed1981

The inhibitory effect of chlorhexidine digluconate on dental plaque formation. A scanning and transmission electron microscope study.

The purpose of this study was to determine the effect of chlorhexidine digluconate mouthrinses on the development of dental plaque in man. The dental plaques were formed on strips of triacetylcellulose film (TAC), which were attached to the lingual surfaces of the mandibular incisors by silk suture thread on 20 human volunteers. Differences in the degree of plaque formation on TAC films after 2, 4 and 24 hours were observed in placebo vs. chlorhexidine treated samples using both scanning and transmission electron microscopy. It was found that (1) solutions containing chlorhexidine digluconate and lactic aluminum have an inhibitory effect of the development of dental plaque on the TAC film as evaluated by electron microscopy, (2) the TAC film was a convenient model for the study of early dental plaque formation by electron microscopy, (3) the three types of pellicle reported by Tryggve Lie (1977) were also observed, (4) the method enabled evaluation of the bacterial accumulation of TAC films. After 2 hours, there was no visible difference in the bacterial accumulations on placebo or chlorhexidine treated films. After 4 and 24 hours considerable differences were observed.

Adult↗