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Biomedical subjects

T Sekitani

Publications and source records attributed to T Sekitani.

At least 73 records · Page 4Linked to original sources
PubMed1989

Histochemical studies of the vestibular nerve system in the developing chick embryo. Glycoconjugates in the vestibular end organs.

Glycoconjugates of the vestibular end organs in the developing chick embryos were well defined and localized using lectins-HRP (WGA, PNA, UEA-1) and HID-AB stains. In spite of the fact that no differentiation of the otic vesicle was seen on the 4-day-old chick embryos, the luminal surface of the otic vesicle was labeled with lectins. The cupula and otoconia were labeled most intensely with lectins on the 6-day-old chick embryos. The reactivity of lectins with the cupula and otoconia was as follows: WGA greater than UEA-1 greater than PNA. As the vestibular end organs had become mature, the epithelial cells of the semicircular duct, utricle and saccule were labeled with lectins. These findings suggest that glycoconjugates play an important role in the development and formation of the vestibular end organs.

Animals↗
PubMed1989

Counter-rolling after regional destruction of the saccule by laser spot irradiation in the guinea pig.

Destruction of the anterior one-third of the right saccule in the guinea pig resulted in a marked eye deviation simultaneously towards the ear and downward on the operated side and a marked upward eye deviation on the non-operated side in the standard head position. During head inclination towards the operated side, both eyes showed a disturbed ocular counter-rolling (OCR). The disturbance of OCR was more severe in the eye on the operated side than in the eye on the non-operated side. Brief interpretation about eye position in the standard head position in the regional destructive group showed that the eye ball on the operated side showed a marked deviation simultaneously upward and towards the ear, while the eye ball on the non-operated side showed an upward deviation on the 1st and 3rd days after the operation. OCR after regional destruction was seen as follows: During head inclination towards the operated side, both eyes showed disturbed OCR. The disturbance of OCR was more severe in the eye on the operated side. Most animals in our experiment showed this disturbed OCR which was compensated and normalized by the third postoperative week; relatively shorter (faster) than the total destruction. These results suggest that when the head is inclined around its longer axis, the saccule on the side of head inclination plays a principal role in the otolith-ocular reflex.

Acceleration↗
PubMed1989

Serovirological study of vestibular neuronitis.

A serovirological study to clarify the pathogenesis of vestibular neuronitis was made on 44 patients. The diagnosis of vestibular neuronitis was made under the diagnostic criteria. Sera from all 44 cases were collected twice or more at defined intervals. Of these, 36 cases were treated as paired sera. Seventeen out of 36 paired cases showed significant change in serum viral antibody titer (HSV, 2 cases; CMV, 1 case; EBV, 7 cases; rubella, 2 cases; adeno., 2 cases; influ. A, 1 case; influ. B, 2 cases). It was assumed that infection caused by these detected viruses played an important role in the onset of vertigo in each case.

Adolescent↗
PubMed1989

Vestibular neuronitis. Pathogenesis in the view of virological study of CSF.

Cerebrospinal fluid (CSF) samples from 15 patients with vestibular neuronitis were virologically examined and analyzed, and compared to those from 16 patients with Hunt's syndrome. The results were as follows: The CSF protein in vestibular neuronitis showed an increase, beginning about two weeks after the onset of vertigo, while the cell count remained normal. The CSF protein in Hunt's syndrome rose, but its progress was different from that in vestibular neuronitis. In both diseases, the increase in CSF protein seemed to be due to protein originating in the blood; the increase was probably caused by a disorder of the blood-CSF barrier. There was no direct evidence of an increase in IgG nor viral antibody titers in the CSF in vestibular neuronitis. In cases of Hunt's syndrome with CSF pleocytosis, intrathecal IgG synthesis was detected. It might be possible that HSV or EBV infection can be confirmed serologically in some cases of vestibular neuronitis and that, in those cases, pathogenesis of vestibular neuronitis is similar to that of Hunt's syndrome.

Adolescent↗
PubMed1988

Differential diagnosis of vertigo--combined galvanic test and MRI.

Differential diagnosis of the disease entities of vertigo are important in clinical investigations. Many concepts and procedures have been proposed for available diagnostic tests. Recent basic and clinical studies proved the efficacy and reliability of galvanic tests, including galvanic nystagmus test (GNT) and galvanic body sway test (GBST), emphasizing that the effects of galvanization are: 1) on the action potential in vestibular nerve and 2) on the resting discharge of the vestibular nerve. These suggest further that galvanic nystagmus reaction (GNT) is mainly a manifested reaction of the semicircular canal system, while galvanic body sway such as spinal reflexes (includ. GBST) are mainly a reaction of the otolithic system. The purpose of this paper is to review briefly the previous results of GBST in our laboratory; and to introduce a newly devised combined galvanic test, simultaneous recording of both GBST and GNT; and also introduce magnetic resonance imaging (MRI) of the brain including the cerebrum, cerebellum with brainstem relating the central vestibular system, both of which help us to make a more defined diagnosis of the central origin vertigo. On CGT of a normal subject, galvanic eye movements are constantly induced showing the initial eye deviation and the following main deviation during galvanization, on both eyes, which are almost similar and occur synchronously. Galvanic body sway is also induced well with individual components, as described in the previous papers. CGT of the cases with vertigo revealed abnormal response patterns in each disease.

Aged↗
PubMed1985

Effect of visual illusion, circularvection, in flight simulator on posture control.

Occurrence of circularvection and the disturbance of postural control in the fighter flight simulator were studied. The sensation of self-motion, circularvection, in the fighter flight simulator flying in a low-altitude and high-speed (but motionless base) was positive in all of four healthy male adult volunteers. Marked body staggering in the standing test was noted at post-flight. Square Drawing Test (hand writing test) showed some tendency of prolongation of lines, suggesting mis-calibration of fine hand-arm motor control. Nystagmic eye movement, optokinetic, was recorded on ENG during this motionless flight simulator, which increased on banking.

Adult↗
PubMed1985

Vestibular neuronitis: neurotological findings and progress.

Neurotological follow-up observations were conducted on 38 of 43 cases of vestibular neuronitis treated between 1972 and 1983. The average observation period was 1 year and 3 months (range from 1 month to 9 years and 4 months) and 17 cases were followed for more than 1 year. The tests used for evaluation in this series were the following: spontaneous nystagmus, head positional nystagmus, a caloric test and a computed galvanic body sway test (GBST) conducted by Yamaguchi University. Changes in subjective symptoms are also noted. The main subjective complaint was vertigo (whirling; 93%). The remaining subjects noticed a floating sensation and unsteadiness of gait. In 50% of the cases, vertigo subsided by the end of the 3-month period, but 6 subjects suffered from an intractable dizzy sensation for over 1 year. Even after 3 years, 3 of these 6 cases were bothered by dizzy sensations. Especially in the central lesion, these 3 subjects had no other causative disease. Spontaneous nystagmus, which was usually horizontal and direction fixed, remained in 50% of the cases after the 1-year period. All of the cases tested showed reduced caloric responses. 21 of the 38 cases showed no response in cold caloric stimulation (including ice water) at the initial test. 13 of the 21 cases were followed satisfactorily and examined twice or more by caloric testing. 5 of these 13 cases did not recover in the caloric test even after more than 1 year.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

Mucoepidermoid carcinoma of the vocal cord. Report of a case.

A case of mucoepidermoid carcinoma of the vocal cord is described in a 51-year-old man who presented with a thickened right vocal cord at the midportion without any limitation of movement. Histological examination revealed a mucoepidermoid carcinoma of low-grade malignancy. Partial laryngectomy was performed, but 10 months after the operation a squamous cell carcinoma developed on the other vocal cord. Primary vocal cord involvement of this tumor is rare. The literature is reviewed.

Carcinoma↗
PubMed1983

Vestibular neuronitis--its clinical characteristics.

Several parts of a nationwide survey of the epidemiology of vestibular neuronitis were reported. Follow-up studies of vestibular neuronitis were made. The computed galvanic body-sway test (Yamaguchi University) obtained from 10 patients with vestibular neuronitis showed a peculiar 'slow and sluggish' pattern. In the course of the illness, this slow and sluggish pattern changed its appearance and soon resembled the pattern obtained from the opposite, healthy side. Improvement of the abnormal pattern was observed in 7 patients (observation period 6 months to 6 years, averaging 33 months). 3 other patients (observation period 1 month to 1 year, averaging 5.3 months) showed no improvement in the pattern. These findings suggest that the conductivity of the vestibular nerve affected by vestibular neuronitis has an increasing chance for recovery.

Adolescent↗