Search PubMed⌕ Search

Biomedical subjects

T Sekino

Publications and source records attributed to T Sekino.

At least 37 records · Page 2Linked to original sources
PubMed1988

Subdural tension pneumocephalus following surgery for chronic subdural hematoma.

The computerized tomography (CT) findings were analyzed in five cases of subdural tension pneumocephalus following surgery for chronic subdural hematoma. They were compared with CT scans in 14 cases of asymptomatic subdural pneumocephalus. In this study, two new CT findings were identified that suggest increased tension of the subdural air. Subdural air separates and compresses the frontal lobes, creating a widened interhemispheric space between the tips of the frontal lobes that mimics the silhouette of Mt. Fuji. The presence of air between the frontal tips associated with massive air inclusion over the frontal lobes presumably indicates increased tension of the subdural air. The "Mt. Fuji sign" was seen in four of the five cases with subdural tension pneumocephalus. The other finding was the presence of multiple small air bubbles scattered through several cisterns ("air bubble sign"). It is postulated that these air bubbles enter the subarachnoid space through a tear in the arachnoid membrane caused by increased tension of air in the subdural space. This finding was seen in four cases with subdural tension pneumocephalus. These two CT findings are helpful in making a diagnosis of subdural tension pneumocephalus following surgery for chronic subdural hematoma.

Aged↗
PubMed1988

[Traumatic enucleation of the eye ball--report of a case and considerations concerning the pathogenic mechanism of intracranial complications].

A 48-year-old man had his left eye ball enucleated by fingers of an assailant. The optic nerve, measuring 4 cm in length, was attached to the enucleated eye ball, but there was neither a wound in his eyelids nor cerebrospinal fluid leakage from inside the orbit. He was confused, but responsive and was able to recognize other persons with his right eye. His right-eye vision deteriorated within 24 hours and was almost totally lost for about one month. Three months after the trauma his vision recovered to 0.1, but his visual field showed severe concentric narrowing. An emergency CT on admission showed a small subarachnoid hemorrhage in the suprasellar cistern, and follow-up CT scanning on day 7 demonstrated a small infarction in the left globus pallidus and putamen. Cerebral angiography performed on day 17 showed residual vasospasm of the horizontal portion of left anterior cerebral artery. Left ophthalmic artery was patent and there was no aneurysm formation either on the intracranial or on the intraorbital arteries. Literature review yielded only three cases of eye ball enucleation by an assailant. Intracranial complications reported in the literature, including those associated with eye ball enucleation caused by other mechanisms, are; contralateral visual field defect: seven cases, hypothalamic involvement: two cases, subarachnoid hemorrhage: two cases, cerebrospinal fluid leakage: one case, and meningitis: one case. The optic nerve, from just behind the eye ball to the chiasm, is reported to be 40-50 mm long, and eye ball enucleation with the optic nerve measuring 4 cm or more is quite likely to cause intracranial complications such as are cited above.

Brain Diseases↗
PubMed1988

Heterogeneity of the immune status concerning anti-thyroglobulin antibody production among patients with Hashimoto's thyroiditis; an in vitro study.

In vitro anti-thyroglobulin antibody (TgAb) production by unstimulated, thyroglobulin (Tg)-stimulated and pokeweed mitogen (PWM)-stimulated peripheral blood lymphocytes (PBL) from 44 patients with Hashimoto's thyroiditis and 10 normal individuals was investigated using a biotin-avidin enzyme-linked immunosorbent assay. Spontaneous TgAb production by non-T cells alone was observed in some patients. TgAb production induced by Tg was T cell-dependent and not accompanied by nonspecific IgG production. PBL from normal individuals produced no TgAb under any conditions. The patients were divided into four groups: 24 showed no TgAb production under any conditions, eight showed TgAb production only with PWM, seven produced TgAb spontaneously and more with both Tg and PWM, and five showed spontaneous TgAb production but no increase with Tg (four of these five patients showed an increase with PWM). Significant positive correlations between the serum TgAb titre and the amounts of TgAb produced by unstimulated, and Tg-stimulated and PWM-stimulated PBL were observed. It was suggested that spontaneous TgAb production was due to in vivo triggered antibody-producing B cells, while the TgAb produced only after in vitro Tg stimulation would be due to Tg-specific memory B cells helped by Tg-specific T cells. The increase in TgAb production due to PWM may be caused by activation of nonspecific helper T cells. These different PBL profiles probably reflect the heterogeneity of the immune status concerning TgAb production among patients with Hashimoto's thyroiditis.

Adult↗
PubMed1987

[Subdural tension pneumocephalus following surgery of chronic subdural hematoma].

Subdural tension pneumocephalus (TP) following surgery for chronic subdural hematoma was analyzed in 5 cases from clinical standpoints of view, especially from CT findings. The cases were compared with 14 cases of subdural asymptomatic pneumocephalus (AP). The TP tends to complicate elderly patients who showed a poor re-expansion of the brain after irrigation of bilateral chronic subdural hematoma. In such patients, it is difficult to make an exact diagnosis of TP because of residual mass effect of the evacuated hematoma. Significance of mass effect caused by subdural air has been discussed in the literature only little. In this study, we found two new CT findings suggesting increased tension of subdural air. First, the subdural tensive air separates and compresses the frontal lobes. The compressed frontal lobes with widened interhemispheric space between the frontal poles mimic the silhouette of Mt. Fuji. We called this CT finding "Mt. Fuji" sign. The presence of air between the frontal poles associated with massive air over the frontal lobes presumably indicates an increased tension of the subdural air. "Mt. Fuji" sign was seen in 4 cases out of 5 TP cases. Another sign is the presence of multiple small air bubbles in the subarachnoid space, especially in the cisterns. We proposed that these air bubbles were trapped in the subarachnoid space through a tear of the arachnoid membrane which is caused by increased tension of air in the subdural space. This finding was present in 4 cases with TP. We emphasize that these two CT signs are helpful to make an accurate diagnosis of TP following surgery for chronic subdural hematoma.

Aged↗
PubMed1986

[Traumatic aneurysm occurring after surgical procedure of large cerebral aneurysm].

A case of intracranial traumatic aneurysms occurring after surgical treatment of a large cerebral aneurysm is reported. A 56-year-old man was admitted to our department with complaints of headache, nuchal pain and nausea. Left carotid angiography (Lt-CAG) revealed a large aneurysm, measuring 20 mm in maximum diameter, of the azygos anterior cerebral artery. Successful clipping operation was performed on day 17 of subarachnoid hemorrhage. Unfortunately, small cortical branches were pulled out during the procedure from the right pericallosal artery. The postoperative Lt-CAG showed formation of two other aneurysms. Second operation was done on day 28 after the first operation. These aneurysms were located at the previously injured sites on the right pericallosal artery. From the history sited above, we diagnosed them as traumatic aneurysms. The second operation resulted in successful obliteration of these two traumatic aneurysms. Literature review yielded 25 similar cases, and the authors discuss the etiologic factors of the traumatic aneurysm due to surgical procedure.

Cerebral Angiography↗
PubMed1985

Correlation between plasma fibrin-fibrinogen degradation product values and CT findings in head injury.

Plasma fibrin/fibrinogen degradation product (FDP) determinations and CT scans were performed in 26 patients on the first, third, and seventh day after head injury. Plasma FDP concentrations were increased in the patients with cerebral contusion shown on CT scans, while the plasma FDP values were normal in the patients with various sized epidural haematomas. Furthermore, the plasma FDP elevation appeared to be more marked and more prolonged in the patients with severe contusion than in those with mild contusion. These findings suggest that the degree of the increase in plasma FDP is proportional to the amount of brain tissue destruction.

Brain Concussion↗
PubMed1979

Acidic glycosaminoglycans in human esophagus tissue.

The constitution of acidic glycosaminoglycans (AGAG) in the normal human esophagi which were obtained at autopsy from 13 female subjects, from 30 to 59 years old, was biochemically analyzed by the procedures such as resin chromatographic separation, electrophoretic characterization in 3 buffer systems and enzymic assay with chondroitinases and hyaluronidase. The main AGAG was hyaluronic acid which amounts to a half of total AGAG, followed by heparan sulfates and dermatan sulfate one fifth of total AGAG each, and small amounts of chondroitin-4- and -6-sulfates and oversulfated chondroitin sulfate. Heparin was not detected. A possible role of the esophageal AGAG was discussed.

Adult↗
PubMed1978

Age-dependent constitutional change in acidic glycosaminoglycans in human esophagus.

The age-dependent constituents of esophageal acidic glycosaminoglycans (AGAG) were studied using 35 healthy individuals by electrophoretic characterization and enzymic assay with specific chondroitinases and hyaluronidase. Human esophageal AGAG comprised hyaluronic acid, dermatan sulfate, heparan sulfate and chondroitin 4- and 6-sulfate and oversulfated dermatan sulfate. Hyaluronic acid was the major part of AGAG at the young age but it decreased definitely with the advance of age. The proportion of dermatan sulfate and the oversulfated isomer to total AGAG significantly increased until adult age and then tended to somewhat decrease with increasing age. The proportion of heparan sulfate consistently increased with the advance of age.

Adolescent↗
PubMed1977

A study of acidic glycosaminoglycans in human gastric tissue.

The acidic glycosaminoglycans (AGAG) in normal portions of human gastric tissue were separated by electrophoresis in 3 buffer systems. Paper chromatographic separation of the constitutional disaccharide units by digestion of chondroitin sulfates (CS) with chondroitinase-ABC and chondroitinase-AC was carried out after fractionation of CS by ion-exchange resin column chromatography. Thin-layer chromatography of hexosamines and other biochemical analysis were also performed. The presence of hyaluronic acid in the gastric tissue was substantiated by the enzymatic susceptibility to streptomyces hyaluronidase. The results indicated that human gastric AGAG consisted of, in the order of amount, heparan sulfates, dermatan sulfate, hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate and presumably oversulfated chondroitin sulfate.

Adult↗