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T Schuster

Publications and source records attributed to T Schuster.

121 records · Page 7Linked to original sources
PubMedDate not supplied

The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization.

The GUT1 gene of Saccharomyces cerevisiae, encoding glycerol kinase, was cloned and sequenced. The cloned genomic DNA fragment contains an open reading frame potentially coding for a protein of 709 amino acids with homology to bacterial glycerol kinases (40.8% identity over 502 amino acids, and 42.1% identity over 496 amino acids, in comparison to the smaller E. coli and B. subtilis enzymes). Disruption of GUT1 showed that the gene is required for growth on glycerol, but not on glucose or ethanol media. No glycerol kinase activity was detected in the disruption mutant. According to enzyme activity and transcript analysis, synthesis of glycerol kinase is repressed by glucose, and derepression is ADR1-dependent.

Amino Acid Sequence↗
PubMedDate not supplied

Primitive neuroectodermal tumor of the pancreas. An extremely rare tumor. Case report and review of the literature.

Peripheral primitive neuroectodermal tumor (PPNET) is a malignant neoplasm of the peripheral nervous system and soft tissues. Representing the fourth case published we herein report a PPNET arising in the pancreas of a six year old girl. She presented with severe anemia due to ulcerative tumor growth and hemorrhage into the duodenum. From the first biopsy pancreatoblastoma was considered as histological diagnosis. Therefore pancreato-duodenectomy was successfully performed. Immunohistochemically, the tumor cells were positive for cytokeratines and several neuronal markers. Due to focal membranous staining for MIC-2 gene product and rosettes in one lymph node metastasis the diagnosis had to be altered into PPNET. This was confirmed by cytogenetic analysis. We conclude that the interpretation of histologic sample excisions from pediatric pancreatic neoplasms may be difficult and that PPNET should be included in the differential diagnosis.

12E7 Antigen↗
PubMedDate not supplied

[Circumcision--criticism of the routine].

Circumcision is one of the most frequent operative procedures done in males. About 120 circumcisions are performed every 5 minutes over the world [14]. Three different reasons lead to circumcision: 1) Medical reasons in present of a pathologic phimosis. 2) Circumcisions done due to religious, social or cultural rea-reasons. 3) Finally in many countries circumcision is performed as "routine-circumcision" in the newborn period. While in the United States the number of routine-circumcisions decreases (about 60% of all male newborns) South-Korea has a rate near to 100%. Even with no religious or cultural background in Germany circumcision often is performed without scrutinizing medical indication. Circumcision is regarded as an procedure with no complications and no disadvantage for the patient. In general circumcision has no medical benefit neither in decreasing the incidence of urinary tract infections nor of sexual transmitted diseases nor of neoplasias. Medical indication for circumcision is given in present of pathologic phimosis in 4% of all males. Postoperative complications range up to 2% and "circumcision is the amputation of the prepuce from the rest of the penis, resulting in permanent alteration of the anatomy, histology and function of the penis...". There are many reports about having discomfort and disadvantages after circumcision as well to the males as to the sexual partners. This challenge the legality of neonatal involuntary circumcision because legality is based on saving the children's best interests.

Circumcision, Male↗
PubMedDate not supplied

Importance of periodic reeducation of hospital-based nurses in capillary blood glucose monitoring and an evaluation of the usefulness of reflectance meters.

Precision and accuracy of capillary blood glucose measurements performed by general staff nurses were assessed before and after a modest reeducation program both with and without the use of reflectance meters. A total of 380 capillary glucose determinations were performed by nurses and the hospital laboratory on the same samples. Prior to reeducation, nurses using meters were more accurate than those reading visually, but no difference was found in precision. Reeducation improved precision equally in both groups while improving accuracy only in the group using meters. While glucose readings with the use of reflectance meters were statistically more accurate than those read visually, the percentage of readings within 10% and 20% of the laboratory readings was the same. Thus, the increased accuracy observed with meters may have little practical significance, suggesting that their use might better be based on other considerations, such as user confidence, convenience, cost, and quality control. Periodic education is, however, an essential component of any quality assurance program.

Blood Glucose Self-Monitoring↗