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Biomedical subjects

T Schonfeld

Publications and source records attributed to T Schonfeld.

31 records · Page 2Linked to original sources
PubMed1988

Determination of blood gases in children with extreme leukocytosis.

The effect of extreme leukocytosis (greater than 300,000/mm3) on the PaO2 of blood stored at 22 degrees and 2 degrees C was studied in two children with leukemia. Arterial blood samples drawn from these patients at 1 and 10 min were compared to blood samples drawn from eight control patients with normal leukocyte counts and PaO2 levels in the same range. One minute after drawing the samples, the PaO2 values at 2 degrees C were significantly higher than those stored at 22 degrees C. Later, there was a rapid and progressive decline in PaO2 values in both samples stored at 2 degrees and 22 degrees C. Rapid consumption of O2 by leukocytes is liable to result in erroneous diagnosis of severe hypoxemia in patients with extreme leukocytosis. Immediate cooling of the samples is insufficient to eliminate this process.

Blood Gas Analysis↗
PubMed1987

Acute hepatic failure after open-heart surgery in children.

Acute hepatic failure (AHF) combined with acute renal failure (ARF) is a well-known complication of open-heart surgery in adults. The occurrence of this complication in two children after open-heart surgery for correction of congenital heart disease is reported. Hypotension occurred during the operation and was treated by catecholamine vasopressors. AHF set in during the postoperative course; it was manifested by impaired consciousness, hypoglycemia, hyperbilirubinemia, hyperammonemia, elevated liver enzymes and prolongation of the prothrombin time with failure of hemostasis. ARF also developed in both children. One of the patients survived the acute episode of hepatic failure. The importance of early diagnosis, routine close monitoring, and appropriate selection of vasopressors is emphasized.

Acute Disease↗
PubMed1983

Differential leukocyte count in acute gastroenteritis. An aid to early diagnosis.

The total and differential leukocyte counts of 238 infants with acute gastroenteritis were evaluated as an aid in differentiating between nonbacterial and bacterial infection. In contrast to the total leukocyte count, which was noncontributory, the absolute band count and the ratio between band and total neutrophil count (B/N ratio) were helpful, with the highest values seen in patients with Shigellosis. A B/N ratio greater than 0.10 can help differentiate Shigella, Salmonella, and Campylobacter infections from E. coli and nonbacterial gastroenteritis with a sensitivity of 84.3 per cent and a specificity of 74.5 per cent.

Campylobacter Infections↗
PubMed1982

Unilateral hydrocephalus due to obstruction of the foramen of Monro: another complication of intrauterine mumps infection?

Unilateral hydrocephalus due to foramen of Monro-obstruction was diagnosed in a newborn who presented with macrocephaly at birth. The mother had mumps in the second trimester of pregnancy and immunological studies indicated possible intrauterine infection of the baby with mumps virus. His condition deteriorated rapidly, and he developed myoclonic seizures. The possible relationship of intrauterine mumps infection to neonatal neurological complications is discussed.

Cerebral Ventricles↗
PubMed1980

Transcutaneous oxygen monitoring during exercise stress testing.

Transcutaneous oxygen tension (tcPO2) was compared with simultaneous arterial oxygen tension (PaO2) in 3 normal young adults and 4 pediatric lung disease patients at rest and during exercise to assess the usefulness of tcPO2 monitoring during exercise stress testing. At rest, the regression coefficient of tcPO2 on PaO2 was 0.78 +/- 0.03 (SEM) (r = 0.924; P < 0.0005). During exercise, the regression coefficient of tcPO2 on PaO2 was 0.88 +/- 0.02 (r = 0.958; P < 0.0005), indicating that tcPO2 approximates PaO2 equally well at rest and during exercise. After a step change in inspired oxygen concentration (FIO2) from 0.21 to 0.17, there was no significant difference in the tcPO2 time constant at rest (66.2 +/- 8.5 s) and during exercise (73.0 +/- 3.1 s). Neither PaO2 nor tcPO2 fell in normal subjects during graded exercise stress testing. However, in 3 of 4 pediatric lung disease patients, there were decreases in both PaO2 (40.7 +/- 11.6 Hg) and tcPO2 (28.7 +/- 10.0 mm Hg) during 7 exercise stress tests. These results indicate that tcPO2 approximates PaO2 equally well at rest and during exercise.

Adolescent↗