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Biomedical subjects

T Schlenker

Publications and source records attributed to T Schlenker.

31 records · Page 2Linked to original sources
PubMed1994

Assisted hatching in the treatment of poor prognosis in vitro fertilization candidates.

OBJECTIVE: To access the effect of augmenting IVF with assisted hatching in the treatment of poor-prognosis patients. DESIGN: Thirty-three poor-prognosis IVF patients were treated with assisted hatching and were compared with 43 control subjects without assisted hatching. SETTING: Center for Reproductive Medicine, Swedish Medical Center, Englewood, Colorado. PARTICIPANTS: Seventy-six women undergoing IVF with a poor prognosis for pregnancy. Poor prognosis was defined as Elevated day 3 FSH level; age > or = 39 years; and multiple prior IVF failures. MAIN OUTCOME MEASURES: Pregnancy and implantation rates per embryo. RESULTS: The incidence of ongoing pregnancy in the assisted hatching group was 64% compared with 19% in the control group. Implantation rate per embryo transferred was 33% in the assisted hatching group versus 6.5% in the control group. CONCLUSIONS: These results demonstrate that assisted hatching, when applied to poor-prognosis patients, improves embryonic implantation and pregnancy rates.

Adult↗
PubMed1994

Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment.

Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease were evaluated after oral administration of a single dose and after long-term treatment. A single oral dose of 1 mg colchicine led to a mean peak concentration of 3.60 +/- 1.04 ng/ml at a peak time of 2.16 +/- 0.34 h and a mean area under the plasma concentration time curve, extrapolated from time 0 to infinity, of 24.90 +/- 8.47 ng.h/ml. Comparable values were obtained after repeated administration. Distribution half-life was 2.83 +/- 0.74 h, and terminal plasma half-life was 9.81 +/- 2.08 h; the mean apparent volume of distribution and the mean apparent plasma clearance were 1448 +/- 4061 and 175.3 +/- 47.6 1/h, respectively. Colchicine concentrations in bile (2025 +/- 1368 ng/ml) were clearly higher than in plasma. Long-term treatment with colchicine (1 mg/day) in patients with various stages of primary biliary cirrhosis (PBC) was associated with colchicine concentrations varying from < 0.15 to 2.0 ng/ml, with a slight tendency to higher concentrations in PBC stages III-IV than I-II. Although about 20% of colchicine is excreted in bile within 24 h, accumulation of colchicine may appear only in patients with advanced liver disease and cholestasis.

Administration, Oral↗
PubMed1993

HIV seroprevalence among patients attending a Milwaukee clinic for sexually transmitted diseases: findings from four annual surveys, 1988-1991.

Blinded HIV seroprevalence surveys were conducted annually from 1988 through 1991 among patients at a Milwaukee sexually transmitted disease (STD) clinic. Among 5,295 patients tested, 70 (1.3%) were HIV-1 Western blot positive. HIV seroprevalence rates were higher among male patients (1.7%) than among female patients (0.5%). HIV seroprevalence increased progressively with age and the number of prior STD episodes. During the four survey periods, HIV seroprevalence increased among teenage STD patients, patients who reported no prior STD, and patients without determined risk exposures. Selective voluntary HIV testing of patients who reported high risk exposures failed to detect 80% of all HIV seropositive patients. Because STD clinic patients are at high risk of HIV infection, HIV antibody testing, with appropriate referral of patients who test positive, and risk reduction education should be made routinely available to all STD patients with or without HIV-associated risk exposures.

Adolescent↗
PubMed1992

[Antineutrophil cytoplasmic antibodies in chronic inflammatory bowel diseases].

Serum samples from 83 patients (42 women, 41 men, mean age 41 [19-85] years) with chronic inflammatory bowel diseases (ulcerative colitis: n = 41, Crohn's disease: n = 42) of differing degrees of activity were tested for antineutrophil cytoplasmic antibodies (ANCA) by immunofluorescence microscopy and various ELISA techniques. Seven patients with ulcerative colitis and one with Crohn's disease were suffering from associated primary sclerosing cholangitis. ANCA were detected in 18 sera, 13 from patients with ulcerative colitis (31.7%) and five from patients with Crohn's disease (11.9%). Six of the eight patients with primary sclerosing cholangitis were ANCA-positive. Nine sera showed a cytoplasmic (c-ANCA-) pattern and 9 others showed a partially atypical perinuclear (p-ANCA-) pattern. Among the ANCA-positive sera, ELISA techniques showed that two had antibodies against serine proteinase 3, two against lactoferrin, two against elastase and one against myeloperoxidase. There was no correlation between the anatomical pattern or activity of the disease and the presence of ANCA. The antineutrophil cytoplasm antibodies demonstrable in chronic inflammatory bowel disease appear to be directed against so far unknown antigens. They are particularly frequent in patients with associated primary sclerosing cholangitis.

Adult↗
PubMed1991

Lower pregnancy rate with premature luteinization during pituitary suppression with leuprolide acetate.

The relationship of the circulating level of progesterone (P) on the day of human chorionic gonadotropin (hCG) injection to occurrence of clinical pregnancy was examined in 133 leuprolide acetate human menopausal gonadotropin (hMG) in vitro fertilization cycles in women having at least three embryos transferred. Progesterone concentrations greater than 0.5 ng/mL were associated with a significantly lower rate of pregnancy (12/59, 20%) compared with less than 0.5 ng/mL (40/74, 54%, P less than 0.005). The higher P cycles were associated with greater patient age and hMG dose, although these relationships appeared to be indirect. Luteinizing hormone (LH) concentrations remained suppressed. Ovarian stimulation may cause excessive luteinization and an adverse cycle outcome even in the presence of low LH levels. Prospective use of P levels may be helpful to determine optimal hCG timing.

Adult↗
PubMed1990

Measles in Milwaukee.

All measles cases in Milwaukee for 1989 and the first quarter of 1990 are analyzed according to epidemiological and clinical parameters. Two major outbreaks are described with special attention to the demographics of the populations involved and the variety and severity of clinical outcomes. Health care and health insurance as they relate to the treatment and prevention of measles during this time are also discussed.

Adolescent↗
PubMed1989

The effects of lead in Milwaukee's water.

Lead concentrations in household drinking water were matched with blood lead levels in 46 women of childbearing age (37 of whom were pregnant) who reside within the city of Milwaukee. The women represented a geographically diverse sample. Water lead concentrations ranged from less than 10 micrograms/L (65% of all homes studied) to 160 micrograms/L. None o the women tested had blood lead levels within the range most recently designated by the Centers for Disease Control (CDC) as "at risk" for the developing fetus (greater than or equal to 10 micrograms/dL). Within the limits of this study, there was no biologically significant correlation between blood lead and drinking water lead levels, suggesting that household water in Milwaukee with first-draw lead concentrations above EPA standards, either proposed or current, may have little or no biological effect.

Female↗