Biomedical subjects

T Saxne

Publications and source records attributed to T Saxne.

95 records · Page 6Linked to original sources

PubMed1985

Difference in cartilage proteoglycan level in synovial fluid in early rheumatoid arthritis and reactive arthritis.

Cartilage proteoglycans were measured, by the use of an enzyme-linked immunosorbent assay, in synovial fluids obtained from 109 unselected patients attending an outpatient rheumatology clinic because of inflammation of the knee. The content of proteoglycans in synovial fluid was inversely related to the degree of joint destruction shown on X-ray. The proteoglycan concentrations in knee-joint exudates were higher in patients with reactive arthritis than in patients with rheumatoid arthritis having synovitis of corresponding duration and lacking radiological evidence of cartilage destruction. The measurement of proteoglycan levels may therefore be useful in differentiating between the two conditions.

Arthritis↗

PubMed1984

Factors related to the progression of joint destruction in rheumatoid arthritis.

In 103 (M = 25, F = 78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (alpha 1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of delta LI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p less than 0.05). delta LI was larger in females than in males (p = 0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years. delta LI was larger in the former group (p = 0.005). Comparing women with the largest delta LI (19-44 units) with the remainder ones (delta LI = -9-18 units), CRP and haptoglobin was higher and IgM lower in the former group (p = 0.03, 0.02 and 0.03 respectively). In women with DoD 1-6 years (and only in this interval) significant linear relationships were found between delta LI and hemoglobin (r = 0.52, p less than 0.01) Ritchie index, haptoglobin, CRP (r = 0.41-0.46, p less than 0.05) and IgM (r = -0.43, p less than 0.05). The mean of repeated hemoglobin values correlated even more strongly with delta LI (r = 0.70, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1982

Preleukemic syndrome simulating SLE. A case report.

A 70-year-old man presented with symmetrical arthritis and arthralgias, Raynaud's phenomenon, pleurisy, fever, maculopapular erythema, leuko- and thrombocytopenia, anemia, antinuclear antibodies and hypocomplementemia. His bone marrow morphology was normal. During therapy with corticosteroids he developed pulmonary tuberculosis which responded well to tuberculostatic treatment. Approximately one year after onset of his initial symptoms, myeloblasts were seen in the blood and a few weeks later the bone marrow showed a myeloblastic leukemia. The patient did not respond to cytostatic treatment and died six weeks later. Although this patient presented symptoms suggesting the diagnosis of SLE, in retrospect his condition probably represented an unusual type of preleukemic syndrome.

Aged↗

PubMed1980

Plasma levels of beta 2-microglobulin in rheumatoid arthritis.

A simple and inexpensive method is described for the determination of beta 2-microglobulin (beta 2-MG) by enzyme-amplified single radial immunodiffusion. The values obtained with this method correlate well with those determined by means of a commerical RIA kit. Using the immunodiffusion method we have measured the plasma levels of beta 2-MG in 135 patients with rheumatoid arthritis (RA) and normal serum creatinine levels. 33% of the patients had increased concentrations of beta 2 MG, but the levels were found to correlate poorly with the values of several variables generally used as indices of the degree inflammatory activity in RA. Furthermore, in contrast to earlier claims to the contrary, beta 2-MG correlated positively with age. The value of beta 2-MG in plasma as an index of inflammatory activity in RA is questioned.

Adult↗

PubMedDate not supplied

Human monocyte elastolytic activity, the propeptides of types I and III procollagen, proteoglycans, and interleukin-6 in synovial fluid from patients with arthritis.

Elastolytic activity by live human monocytes (M phi) is mainly caused by cell surface related leucocyte elastase, capable of degrading matrix components. In order to examine the possible correlation between enzyme activity and tissue turnover in the joint, we examined 24 synovial fluids for M phi elastolytic activity, using the levels of synovial fluid interleukin-6 and serum C reactive protein as additional markers of cell activation. Proteoglycan levels were measured as an indication of cartilage degradation and the types I and III procollagen propeptides as markers of synovial membrane turnover. We found that elastolysis by live M phi and the levels of interleukin-6 and C reactive protein correlated significantly with proteoglycan concentrations but not with the procollagen propeptides. These findings suggest that human M phi elastolytic activation is a biologically relevant factor in cartilage degradation, but is unrelated to the collagen metabolism of the synovial membrane.

Adult↗