Biomedical subjects

T Sauer

Publications and source records attributed to T Sauer.

95 records · Page 6Linked to original sources

PubMedDate not supplied

Influence of pancreatic secretion on late radiation enteropathy in the rat.

In female Wistar rats a 10 cm long exteriorized mid small intestinal segment was roentgen irradiated 3 weeks after a pancreatic duct-occluding operation/sham operation. Roentgen doses were 19 and 21 Gy as single exposures. Radiation injury was assessed 2, 8 and 26 weeks after irradiation using one macroscopic and 7 histopathologic parameters. The parameters were graded according to severity, and a radiation injury score was calculated by adding the scores for the individual parameters. Two and 8 weeks following irradiation there was no difference between pancreatic duct-occluded and sham operated animals. Twenty-six weeks after irradiation all parameters of radiation injury except the extent of vascular sclerosis were less marked in pancreatic duct-occluded rats than in controls. It is concluded that exocrine pancreatic secretions may influence the development of late changes following irradiation, and that these changes seem to be mainly independent of the degree of vascular sclerosis.

Animals↗

PubMedDate not supplied

Value of hydroxyproline measurements in the assessment of late radiation enteropathy.

In female Wistar rats roentgen irradiation of a 10 cm long temporarily exteriorized mid small intestinal segment was performed. Hydroxyproline, proline, aspartic acid and threonine were measured in intestinal samples 2 to 44 weeks after single or fractionated irradiation, and compared with a histopathologic radiation injury score in order to determine their value as assays of late radiation enteropathy. Two to 4 weeks after irradiation there was good correlation between the histopathologic injury score and the content of hydroxyproline. During the late observation period, there was no difference in hydroxyproline concentration between irradiated and sham-irradiated animals. There was no difference in hydroxyproline concentration in samples from the 1, 2 or 3 fractions groups, although the relative amount of non-collagen protein seemed to increase with fractionation. Determination of the hydroxyproline concentration may be used as an assay of early radiation injury, but it seems to be less suitable for late radiation enteropathy assessment.

Animals↗

PubMedDate not supplied

Late radiation enteropathy following split-dose irradiation of rat small intestine.

In female Wistar rats roentgen irradiation of a 10 cm long exteriorized mid small intestinal segment was performed. The radiation dose was 23 Gy, given as a single exposure or divided in two equal fractions separated by intervals of 4 to 96 hours. Radiation injury was assessed 2, 8 and 26 weeks following irradiation using a semiquantitative histopathologic scoring system. An increased fractionation interval led to a reduced degree of radiation injury at all 3 observation times. The greatest difference was found between the single dose and 4 hour groups, indicating a relatively large capacity for repair of sublethal damage. The degree of radiation injury also decreased significantly when the interval between fractions was increased from 4 hours to 96 hours. This suggests that the phenomenon of slow repair may occur in cells involved in the development of late radiation enteropathy. However, an indirectly protective effect due to mucosal repopulation between fractions may also explain some of the differences.

Animals↗

PubMedDate not supplied

Breast cancer in the contralateral breast: incidence and histopathology after unilateral radical treatment of the first breast cancer.

The objective of the study was to assess the 10-year cumulative risk and clinical risk factors for the development of a contralateral cancer and to compare the tumours histopathologically. Among 1980 consecutive radically treated breast carcinoma patients a separate malignant breast tumour was diagnosed in 90 and 74 could be histopathologically compared with the primary tumour. The 10-year cumulative risk was 6.5% (95% CI: 5-8%). There was no difference in 10-year cumulative risk in developing a second breast tumour comparing premenopausal (7.1%) with postmenopausal women (6.1%). The cumulative risk among premenopausal tamoxifen-treated women (19.3%) or among patients with relapse (13.8%) was significantly increased as compared to similar patients without tamoxifen or without relapse. Sixty-six percent of the tumours displayed different histopathology. Morphologically similar and different tumours developed almost equally among patients with synchronous tumours and in those with or without relapse. We conclude that a radically treated breast cancer patient has a 10-year cumulative risk of 6.5% to develop a new malignant breast tumour. In premenopausal women the tumour-protective effect of two years tamoxifen application seems questionable. Histopathological comparison of the bilateral breast tumours enables discrimination of bilateral breast tumours as two primaries in 2/3 of the patients with morphologically different tumours.

Adult↗

PubMedDate not supplied

Mediastinal fibrosis. A case report.

Mediastinal fibrosis may be part of a multifocal fibrotic disease, including retroperitoneal fibrosis, lung fibrosis and Riedel's struma. A case of mediastinal fibrosis, with a previous history of retroperitoneal fibrosis and lung fibrosis, is discussed. There are many known causes of retroperitoneal and mediastinal fibrosis, but as in the present case the etiology often remains unknown.

Biopsy↗