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Biomedical subjects

T Satoh

Publications and source records attributed to T Satoh.

At least 1,351 records · Page 75Linked to original sources
PubMed1976

Surgical treatment of large ventricular septal defect with pulmonary hypertension in the first 24 months of life.

A total of 74 patients under 24 months of age with large ventricular septal defects (VSD) and pulmonary hypertension were subjected to surgical treatment from 1969 through 1975. Emergency pulmonary artery (PA) banding was performed in 13 patients during the first year of life with 1 death from postoperative respiratory failure. Primary closure of the VSD was performed in 61 patients using simple hypothermia and short-term coronary perfusion, with an operative mortality of 1.6%. There were no late deaths or neurological disturbances. Normal hemodynamic data were obtained in all 7 patients who underwent postoperative cardiac catheterization from one month to five years after the primary correction. It is concluded that primary closure of a VSD in infancy is reasonable and that PA banding is indicated only for those patients less than 6 months old with a complicated defect or in an emergency situation.

Cardiac Surgical Procedures↗
PubMed1976

Effect of lyophilization and storage of liver 9,000xg supernatant fraction on the metabolism of imipramine in several species of animals.

Effects of lyophilization and storage of liver 9,000xg supernatant fraction on the activity of drug metabolizing enzymes in some species of animals were studied. Imipramine metabolizing enzyme activity and the content of cytochrome P-450 were stable for, at least, one month without any loss of the activity when lyophilized liver 9,000xg supernatant fraction of some animal species, i.e., rat, mouse, guinea pig, rabbit and dog, was stored under reduced pressure in a deep freezer (-20 degrees C). There were no differences of imipramine metabolism between lyophilized liver 9,000xg supernatant fraction which was kept in a deep freezer for one month and a fresh fraction which was prepared immediately before determinations of the enzyme activity and cytochrome P-450. The data presented here indicated that the lyophilized preparation of the liver 9,000xg supernatant as well as the fresh preparation can be used for the determination of the drug metabolizing enzyme activity.

Animals↗
PubMed1975

Reticulo-reticular relationship during sleep and waking.

The mode of interaction between so-called sleep-waking centers during different phases of consciousness was investigated in the cat. Averaged evoked responses were recorded from different centers to electrical stimulation of a center. The results showed that most sleep-waking centers are not simply engaged in the realization of a single phase, but operate during different phases in dynamic relationship with other centers. It was suggested that the mechanism of SS would be more diffusely distributed in the brain stem that presently conceived and that in contrast to the mechanism of PS, that of SS would have more extensive interaction with the mechanisms responsible to other phases.

Animals↗
PubMed1975

Activation of tryptophan pyrrolase by benzylhydrazine.

The mechanism responsible for the activation of tryptophan pyrrolase (TP) by benzylhydrazine (BZH) was investigated. The increase in holo/apo ratio of rat TP activity after addition of BZH in concentration of 1 x 10(-4)M, which is a major metabolite of isocarboxazid (ISOC), was higher than those in mice and guinea pigs. In addition, treatment with ISOC to rats (50 mg/kg i.p.) resulted in a significant increase in TP activity. These results suggested that the BZH-induced elevation of TP is at least in part due to a stimulation of conjugation step of TP activity.

Animals↗