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Biomedical subjects

T Satake

Publications and source records attributed to T Satake.

At least 253 records · Page 14Linked to original sources
PubMed1981

Sympathetic nervous systems in chronic hypoxic states from pulmonary tuberculosis: a clinical study on plasma norepinephrine and cyclic AMP levels.

To evaluate the sympathetic nervous activity in chronic hypoxic states, the plasma concentrations of norepinephrine (NE), cyclic adenosine 3', 5'-monophosphate (cyclic AMP), cyclic guanosine 3', 5'-monophosphate (cyclic GMP) and dopamine-beta-hydroxylase (DBH) enzyme activity were measured in 32 patients with pulmonary tuberculosis and 30 normal volunteers. Moreover, the peripheral arterial-venous difference of concentration of these substance, arterial blood gas levels and spirometric data were studied in these patients. The results of this study demonstrated that the plasma NE and cyclic AMP concentrations were directly related to the degree of hypoxemia and some of the spirometric parameters in these patients. It is concluded that sympathetic nervous activity was augmented in chronic hypoxic states, especially with chronic respiratory failure.

Adult↗
PubMed1980

Prostaglandins and cyclic nucleotides: effects of PGI2 and PGE1 on cardiac hemodynamic and coronary arterial and myocardial cyclic nucleotide levels in dogs.

The effects of prostacyclin (PGI2) were compared with those of prostaglandin E1 (PGE1) on the cardiac hemodynamics (coronary blood flow, systemic blood pressure, cardiac output and max dp/dt of the left ventricle) in closed-chest dogs. Moreover, the effects of PGI2 were compared with those of PGE1 on the concentrations of the coronary arterial and myocardial cyclic adenosine 3':5'-monophosphate (cyclic AMP) and cyclic guanosin 3':5'-monophosphate (cyclic GMP) in open-chest dogs. The intraventricular and intravenous injection of 0.1 to 4.0 microgram/kg of POGI2 increased the coronary blood flow and decreased the mean systemic blood pressure. Comparison of dose response curves for PGI2 and PGE1 in relation to the coronary blood flow indicated that PGI2 and 4 times as potent as PGE1. On the other hand, the effect of PGI2 on the systemic blood pressure was twice as potent as PGE1. The concentration of the coronary arterial cyclic AMP was significantly increased by the administration of PGI2 and PGE1 (control group: PGI2 group was 0.201 +/- 0.022 vs. 0.264 +/- 0.017 pmoles/mg tissue, p < 0.05; control: PGE1 was 0.201 +/- 0.022 vs. 0.286 +/- 0.027 pmoles/mg tissue, p < 0.05). The concentrations of the coronary arterial cyclic GMP were not significantly changed by the administration of PGI2 and PGE1, nor were those of myocardial cyclic AMP and cyclic GMP. The changes in cyclic nucleotide levels and cardiac hemodynamics induced by PGI2 were qualitatively similar to those induced by PGE1, but the change caused by PGI2 was greater than PGE1 in the coronary and systemic hemodynamics.

Animals↗
PubMed1980

Plasma levels of cyclic nucleotides in patients with essential hypertension.

We studied plasma levels of cyclic nucleotides and their responses to submaximal exercise as an endogenous adrenergic stimulation in normal subjects, untreated and treated patients with essential hypertension to assess the roles of various hormones and the autonomic nervous system in essential hypertension. Plasma c-AMP level was significantly higher in untreated, diuretic-treated patients and those treated with propranolol than in normal subjects, but plasma c-GMP level was comparable in normal subjects and untreated patients. Plasma c-AMP decreased significantly, whereas plasma c-GMP increase significantly, after chronic propranolol therapy. Plasma c-AMP increased significantly after submaximal exercise in normal subjects, untreated patients and those treated with propranolol, but plasma c-GMP increased significantly only in normal subjects. The increase in plasma c-AMP was significantly higher in untreated patients than in normal subjects and patients treated with propranolol. Moreover, the percent increase in plasma c-AMP was significantly higher in untreated patients than in those treated with propranolol. Therefore, it is suggested that the sympathetic nervous system may be hyperactive, and that a hyperreactivity of the beta-adrenergic receptors may play an important role in essential hypertension.

Adult↗
PubMed1979

Plasma norepinephrine and dopamine-beta-hydroxylase activity in chronic renal failure.

To evaluate the activity of the sympathetic nervous system in chronic renal failure, plasma norepinephrine (NE) and dopamine-beta-hydroxylase (DBH) activity were measured by a radioenzymatic assay and a photometric assay respectively. The level of plasma NE was significantly higher in 14 patients with hemodialysis than in healthy individuals (p less than 0.001). The level of plasma NE fell significantly in 6 patients with hemodialysis receiving 0.30-0.45 mg/day of clonidine hydrochloride (a depressor of the sympathetic outflow from the central nervous system) (p less than 0.05). Systolic blood pressure was correlated with the level of plasma NE in patients with hemodialysis who were not receiving clonidine. They had high level of plasma NE and low level of plasma DBH activity. Therefore, this findings suggest that high level of plasma NE in chronic renal failure is caused not only by decreased urinary excretion, but also by increased overflow from the sympathetic nervous clefts.

Adolescent↗