Search PubMed⌕ Search

Biomedical subjects

T Sakaguchi

Publications and source records attributed to T Sakaguchi.

At least 379 records · Page 21Linked to original sources
PubMed1976

Effects of epinephrine and theophylline on lipolytic response in hereditary diabetic mice.

In non-obese but diabetic 15-week-old KK mice which showed fatty liver histopathologically, the content of liver lipids and the levels of blood glucose and plasma IRI were greater than those in the control ICR mice of the same age and were quite similar to those in GTG-obese mice. In 6-week-old KK mice which excreted no glycosuria and showed normal hepatic tissues, only plasma IRI level was slightly elevated as compared with that in the control mice. The cyclic 3',5'-AMP stimulators like epinephrine and theophylline exerted far less potent stimulatory effects on lipolytic activity in 6-week-old KK mice than in the control mice, as in diabetic 15-week-old KK mice and GTG-obese mice. Theophylline potentiated the lipolytic effect of epinephrine lineraly in KK mice, the tendency being different from that in the control mice, and only the submaximal rate was obtained. Furthermore, the inhibitory effect of theophylline on PDE from the epididymal adipose tissue was less potent in 6-week-old KK mice than in healthy ICR mice of the same age.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1975

Capillary tube urinalysis for small animals.

A simple method was devised using a capillary tube to collect urine for urinalysis. This method offers the following advantages: the animal is not adversely influenced; the collection and analysis of the urine is repeatable; the amount of urine required is small; because of the simplicity of the method, the number of samples tested in a given time can be increased; and contamination with foreign material is reduced, permitting more accurate evaluation of the urinary sediments.

Animals↗