Search PubMed⌕ Search

Biomedical subjects

T Saikia

Publications and source records attributed to T Saikia.

50 records · Page 3Linked to original sources
PubMed1985

Acute leukaemia following malignant ependymoma: a case report.

Though an increasing number of chemotherapy- and radiotherapy-related leukaemias are being reported, acute promyelocytic leukaemia developing as a therapy-related second malignancy is still uncommon. Here we report a case of acute promyelocytic leukemia, microgranular variant, developing in a case of intracranial malignant ependymoma, 1.5 years following treatment with craniospinal radiotherapy.

Adolescent↗
PubMed1985

Pattern of subtypes of acute lymphoblastic leukemia in India.

Leukemic cells from 124 acute lymphoblastic leukemia (ALL) and 31 chronic lymphatic leukemia (CLL) were examined for sheep erythrocyte receptor (E), surface immunoglobulin (SIg) and their reactivity with a panel of monoclonal antibodies recognizing specific surface antigens including pan-T, Common ALL and Ia antigens. In acute lymphatic leukemia, 33% of patients reveal T-cell receptor associated with higher age group, mediastinal mass and high WBC count. Common ALL was predominant between 2 and 9-yr age group. Among chronic lymphatic leukemia, 2 patients were found to be T-CLL while 29 revealed presence of SIg. Ia antigen was detected in 44.4% of ALL and 64% fo CLL patients. The pattern of surface marker observed in our series may be related to our life style, socio-economic and environmental factors.

Acid Phosphatase↗
PubMed1985

T-cell acute lymphoblastic leukemia: a report of 60 patients from India.

60 patients studied at the Tata Memorial Hospital from January 1976 to December 1982 were diagnosed as having T-cell acute lymphoblastic leukemia (ALL) by nonimmune rosette formation with sheep red blood cells. The analysis revealed a high incidence of mediastinal mass (50%) and extramedullary infiltration at presentation. The majority of patients (62%) presented with a high WBC count (greater than 50,000/mm3). Unipolar acid phosphatase activity was observed in 90% of patients. The remission rate with a combination treatment of adriamycin, vincristine and prednisolone was found to be 95%. Long-term survival was around 30%. More aggressive or innovative treatments will be needed to improve the results in T-cell ALL.

Actuarial Analysis↗
PubMedDate not supplied

Acute leukemia with coexpression of lymphoid and myeloid phenotypes.

A multiparameter analysis of 706 cases of acute leukemia (AL) over a two-year period revealed only six cases (0.86 per cent) with coexpression of lymphoid and myeloid phenotypes. In three cases, expression of both lymphoid and myeloid markers by the majority of the blast cells suggested a 'biphenotypic' pattern while in the remaining three cases, the lymphoid and myeloid phenotypes were segregated into two morphologically distinct populations of blast cells indicating a 'biclonal' distribution. The poor response to anti-acute lymphoblastic leukemia therapy in five of these six cases underlines the bad prognostic significance of coexpression of lymphoid and myeloid phenotypes in AL. The incidence of 'mixed lineage' phenotype in the present series appears very low.

Biomarkers, Tumor↗