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Biomedical subjects

T Sada

Publications and source records attributed to T Sada.

At least 55 records · Page 3Linked to original sources
PubMed1982

Polarcardiographic study of inferior myocardial infarction: global projection of heart vector.

The sensitivity of electrocardiographic, vectorcardiographic and polarcardiographic criteria for inferior myocardial infarction was studied. ECG and Frank system VCG were recorded in 50 normal cases and 40 cases of inferior myocardial infarction, whose acute phase was documented by typical electrocardiographic and serum enzymatic changes. The records were made from one month to 16 years after acute attacks. Polarcardiograms were obtained by a specially-designed analogue computer from X, Y and Z signals of the VCG, and recorded at a paper speed of 1000 mm/sec by Mingograph. The polarcardiographic tracings were measured at every 5 msec after onset of the QRS wave, and plotted on the Aitoff's equal-area projection. In normal cases, the QRS vectors plotted on Aitoff's projection passed through the narrow area between 15 to 35 msec after the QRS onset. Electrocardioraphic diagnosis of myocardial infarction was correctly made in 22 cases (55%), and by VCG the sensitivity was improved to 32 cases (80%). Polarcardiographic diagnosis was made in 33 cases (82.5%). Global plots of heart vector on Aitoff's projection were a useful display to visualize the sequential changes of heart vector. In inferior myocardial infarction, the QRS vector passed through the more superior portion to normal, and the diagnosis was accurately made in 33 cases (82.5%).

Adult↗
PubMed1981

Primary thrombocythemia and myocardial infarction in a 26-year-old woman with normal coronary arteriogram.

Acute myocardial infarction occurred in a 26-year-old woman with normal coronary arteriogram and primary thrombocythemia (500,000 approximately 1,500,000/mm3). Hyperaggregability of platelets was also demonstrated by stimulation with adenosine diphosphate, collagen, and epinephrine administration. A stillbirth at the 8th month of gestation in her past history was referred to the complication of primary thrombocythemia, too. Since discharge, the patient has been on 750 mg of aspirin and then free of any thromboembolic symptoms and signs, even during pregnancy and labour.

Adult↗
PubMed1980

Hemodynamic effects of nifedipine in congestive heart failure.

Nifedipine, a potent coronary vasodilator, was administered in a single sublingual dose of 20 mg to eight patients with mild to moderate congestive heart failure. Nifedipine produced a slight increase in heart rate (mean +/- standard error of the mean 73.3 +/- 3.2 versus 80.9 +/- 2.1 beats/min, p < 0.025) and an increase in cardiac index (from a control value of 3.51 +/- 0.22 to 4.06 +/- 0.31 liters/min per m2, p < 0.01). Arterial blood pressure decreased from 112.9 +/- 6.2/67.7 +/- 4.2 (mean 84.9 +/- 4.0) to 100.8 +/- 4.4/56.4 +/- 11.0 (mean 76.1 +/- 4.3) mm Hg (p < 0.01) and total systemic vascular resistance also decreased from a control value of 15.6 +/- 1.0 to 12.4 +/- 0.8 units (p < 0.01) after administration of nifedipine. These data suggest that nifedipine may be useful for vasodilation in congestive heart failure.

Adult↗
PubMed1980

Effects of right and left ventricular pressure overload on left ventricular function and metabolism in dogs.

The effects of acute pressure overload of the right and left ventricle on the left ventricular hemodynamics, coronary circulation, and myocardial metabolism in dogs were investigated by banding of the main pulmonary artery and by producing two models of aortic constriction with (type B) and without (type A) aortocoronary bypass. Pulmonary artery banding (left ventricular preload reduction) showed right ventriculr systolic pressure (RVSP), right ventricular end-diastolic pressure (RVEDP), and right ventricular dP/dtmax significantly elevated, but left ventricular systolic pressure (LVSP), left ventricular (dP/dtmax)/IIP slightly decreased, contrary to a slight increase of left ventricular end-diastolic pressure (LVEDP). The blood flow of the left coronary circumflex artery (CBF) was slightly decreased, but the aortic blood flow (AoF) and left ventricular work per minute (LVW) were significantly reduced. As to myocardial metabolism, the coronary arteriovenous difference (delta) of carbohydrate, mainly glucose (G) and lactate (L), increased, while that of non-esterified fatty acid (NEFA) showed a significant reduction. Aortic coarctation (left ventricular afterload increase) showed, both in types A and B, left ventricular systolic pressure, left ventricular end-diastolic pressure, and left ventricular work per minute were increased. However, aortic systolic and diastolic pressure were significantly decreased. The blood flow of the left coronary circumflex artery tended to increase in both types. The myocardial carbohydrate uptake tended to increase after aortic constriction in both types. However, the uptake of non-esterified fatty acid was increased after aortic constriction in type A, but decreased in type B. This difference in uptake of non-esterified fatty acid might be induced by the difference of the functional state of the left ventricle.

Animals↗
PubMed1979

Halothane solubility in blood during cardiopulmonary bypass: the effect of haemodilution and hypothermia.

The influence of haemodilution and cooling on the solubility of halothane in blood during cardiopulmonary bypass was studied in six normothermic and six hypothermic patients undergoing open-heart operations. The solubility of halothane in blood was 2.17 at 30 degrees C and 1.34 at 37 degrees C. There was also an increase in the blood/gas partition coefficient of about 8.7 per cent for each degree celsius of temperature fall. These changes in haemodiluted blood explain the different anaesthetic requirements observed in patients undergoing cardiopulmonary bypass, either at normal temperature or at moderate hypothermia.

Cardiopulmonary Bypass↗
PubMed1979

Some observations on serum concentrations of digitoxin and digoxin.

Serum concentrations of digitoxin and digoxin were measured in 145 cases with various heart diseases receiving maintenance doses of digitalis. Digitalis toxicity was seen in only 2 cases (1.4%). Day-to-day variation of serum concentration while taking the same daily dose was small in digitoxin therapy (13.8%), but a considerable variation was seen in digoxin therapy (24.4%). Serum concentrations of both digitoxin and digoxin were measured in the patients receiving digitoxin, and there was a positive correlation between the two (r = 0.66, p less than 0.001). This fact suggested that the effect of digitoxin was the sum of the effects of digitoxin and its metabolite, digoxin. In the patients taking digoxin, digitoxin was not detected in the serum. Serum digitoxin level had a significantly positive correlation to serum albumin level, presumably because digitoxin was retained in serum in the bound form to albumin. Minimal effective level, 10 ng/ml, was however obtained with higher daily dose of digitoxin in patients with lower serum albumin.

Adolescent↗
PubMed1978

Persistent atrial standstill developed in a patient with rheumatic heart disease: electrophysiological and histological study.

A case with persistent atrial standstill is presented which developed from atrial fibrillation associated with rheumatic combined valvular heart disease. In addition to clinical and electrocardiographic findings, electrophysiological and histological studies by using microelectrode technique and electron microscopy, respectively, were carried out on specimens from the right atrial appendage resected at mitral valve surgery. Scattered but severe loss of myocardial cells in the atria and deterioration of the action potential of these poorly sustained myocardial cells were confirmed. The suggestive evidence is also shown that the deteriorated action potential observed by micro-electrode technique in this case may be composed of calcium current.

Action Potentials↗
PubMed1977

Cephalic kinetics of intra-arterially injected lidocaine.

The intravenous injection of 3 mg./kg. of lidocaine into the facial artery resulted in internal carotid artery blood levels between 5 and 7 microgram/ml. 15 seconds thereafter. Internal and external jugular vein blood levels exceeded 30 microgram/ml. at the same time. When the same amount of lidocaine was injected into the facial vein, carotid blood levels were less than 3 microgram/ml., peaking at 30 seconds. Concentrations of the local anesthetics in the jugular vein peaked at 15 seconds, exceeding 35 microgram/ml. The feasibility of local anesthetic drugs reaching the cerebral circulation through a retrograde pathway was indicated, suggesting that this mechanism may be the route for some of the untoward reactions observed after the injection of local anesthetics in the head and neck area.

Animals↗
PubMed1977

Myocardial infarction due to metastasis of choriocarcinoma in a 29-year-old woman.

A rare and instructive case of myocardial infarction in a 29-year-old woman was presented. In this case it was clinically suspected that myocardial infarction was due to metastatic choriocarcinoma of the heart. This was confirmed by autopsy. It was emphasized that metastatic choriocarcinoma of the heart could be a cause of myocardial infarction in young women.

Adult↗
PubMed1977

Reverse carotid blood flow--a possible explanation for some reactions to local anesthetics.

In rhesus monkeys, data obtained by contrast radiography and hemodynamic and electroencephalographic studies indicate that carotid blood flow is reversible. Results showed that even small amounts of local anesthetic agents when injected inadvertently into a branch of the external carotid artery, may enter the cerebral circulation, most likely through a retrograde flow into the common and then internal carotid arteries. Some toxic neurologic manifestations possibly may be explained by this mechanism.

Anesthetics, Local↗