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Biomedical subjects

T S Lomovitskaia

Publications and source records attributed to T S Lomovitskaia.

4 recordsLinked to original sources
PubMedDate not supplied

[Dwarfism and the Shereshevskiĭ-Turner syndrome in patients with congenital toxoplasmosis].

Fifty five patients with cerebral and hypophyseal nanism and Shereshevsky-Turner syndrome were examined for toxoplasmosis. The diagnosis of toxoplasmosis was established on the basis of epidemiological and obstetrical anamnesis, clinical and roentgenological data and serological tests (complement fixation test in 2 modifications--by common and droplet method; precipitation test, fluorescent antibody test) and intradermal allergic test with toxoplasmin (ATT). Of 48 patients with cerebral and hypophyseal nanism ATT proved to be positive in 17 (35.4 per cent); it was positive in 3 of 7 patients with Shereshevsky-Turner syndrome. In some of the patients and their mothers serological tests for toxoplasmosis were also positive. Thus, toxoplasmosis infection among the patients examined was 2.5-3 times more incident than the corresponding indices in healthy children. It is supposed that there is pathology of hypothalamic regulation of hypophyseal functions in toxoplasmosis and nanism. A possibility of pathology of the generative apparatus in maternal toxoplasmosis leading to development of chromosomal embryopathies could not be excluded. The authors consider that further studies are necessary for ascertaining (in some of the cases) of the pathogenetic association between toxoplasmosis and growth and developmental disturbances.

Adolescent↗
PubMedDate not supplied

[Clinico-roentgenologic studies in toxoplasmosis patients with various endocrine diseases].

The authors present clinical and roentgenological characteristics of toxoplasmosis revealed in 46 of 128 patients with neuro-endocrine form of diencephalic syndrome, cerebro-hypophyseal nanism and hypogenitalism, examined for toxoplasmosis. Congenital toxoplasmosis was found in 29 and chronic acquired--in 17 cases. It was noted that the clinical picture of both the congenital and of the chronic acquired toxoplasmosis in patients with endocrine diseases was varied due to affection of different organs and systems of the organism. Of great significance in the complex clinico-laboratory diagnosis of congenital and chronic acquired toxoplasmosis was the roentgenological method of study. Roentgenological changes in the skull of the patients with endocrine diseases and toxoplasmosis were expressed in the presence of calcifications of various shape and size (from 2 mm to 2 cm), calcification of the dura mater in the frontal portion and the area of the sella turcica, and hyperostosis. Diagnosis of congenital and chronic acquired toxoplasmosis in patients with endocrine disturbances should be based on the results of complex clinico-roentgenological and laboratory studies.

Adolescent↗