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Biomedical subjects

T S Korshunova

Publications and source records attributed to T S Korshunova.

15 recordsLinked to original sources
PubMed1993

[The compensatory-adaptive mechanisms in nitrite-induced hypoxia in rats].

Concentration of blood proteins, alpha-amino nitrogen, cGMP and endothelin-1,2 was studied in rat's blood at nitric hypoxia. The injection of NaNO2 (5 mg/100 g body weight) was followed by decrease in total protein, albumin and hemoglobin content and by sharp increase in methemoglobin and Hb-NO complexes concentration in rat's blood. Simultaneously, the elevation of free amino acids and peptides with m.w. 2500 D in blood was discovered. One of these peptides was the endothelin-1,2, whose concentration increased twice in plasma at nitric hypoxia. The increase in endothelin and cGMP concentrations is mostly linked with activation of compensative mechanisms, arising as a response to high concentrations of nitro compounds and NO in rats.

Adaptation, Physiological↗
PubMed1986

[Cyclic nucleotides in multiple sclerosis].

The authors studied concentrations of cyclic nucleotides (cAMP and cGMP), as well as their ratio in the blood plasma and cerebrospinal fluid (CSF) of 83 patients with disseminated sclerosis of different forms and variants. An elevation in cAMP concentrations in the plasma and CSF detected in all the patients was more expressed in cases of a long standing and disseminated process. Blood levels of cAMP showed greater variability in the period of exacerbation versus remission of the disease.

Adult↗
PubMed1984

[Endogenous morphines in chronic progressive diseases of the central nervous system].

Using radioimmunoassay the authors studied concentrations of beta-endorphine and metenkephalin in the cerebrospinal fluid (CSF) of 65 patients with various diseases of the central nervous system (CNS)--hereditary extrapyramidal disorders, disseminated sclerosis (DS), lateral amyotrophic sclerosis (LAS), spinal tumours, senile dementia, some CNS impairments of inflammatory nature. Patients with spinal tumours showed a 4-14-fold elevation in metenkephalin levels along with a comparatively high content of beta-endorphine. In senile dementia, the concentration of both peptides was lowered. In hereditary extrapyramidal diseases, the levels of beta-endorphine were also low, while there was no concomitant decrease in the metenkephalin concentration.

Amyotrophic Lateral Sclerosis↗
PubMed1980

[Metabolic disorders in essential tremor].

Various parameters of the carbohydrate, lipid, protein, purine, and trace element metabolism were examined in 82 patients with essential tremor. Hypercholesterolemia, varying changes of the carbohydrate metabolism, lowered uric acid levels in the serum and the urine, and a tendency to a rise of the serum transferrin level were disclosed. The results obtained ae discussed in comparison with metabolic changes in other extrapyramid diseases.

Adolescent↗
PubMed1978

[Metabolic disorders in Huntington's chorea].

The results of biochemical studies conducted in 42 patients with Huntington's chorea are presented. The authors marked the decrease of tolerance to glucose, the increase of cholesterol concentration in the blood serum in some patients. Uric acid concentration in the blood serum and its excretion with urine were decreased in all examined patients. Ceruloplasmic activity in the patients' blood did not differ from the normal level. Cuprum concentration in the blood serum and the patients' urine was within the normal fluctuations.

Adult↗
PubMed1976

[Treatment of amyotrophic lateral sclerosis with ribonucleotides].

In the treatment of 31 patients with lateral amyotrophical sclerosis the authors used the preparation ENKAD containing a complex of mono- and oligoribonucleotides. In 6 cases there was aggravation of the condition while in 18 of the observed cases--improvement. In 7 patients the condition was not altered. The treatment was convened under biochemical control (the assessment of the uric acid in the blood serum and urine and the excretion of oxypurine in the urine). It was possible to depict definite clinicobiochemical correlations. The conclusion is made that ENKAD can be used in the early stages of the disease and mainly in focal segmentary-nuclear lesions. The preparation is contraindicated in generalization of the process and in impetuous development of the disorder.

Adult↗
PubMedDate not supplied

[Do nitrite ions participate in regulating systems of intra- and intercellular signalling?].

Effect of nitrite ions on content of proteins (hemoglobin, albumin and others), peptides (AKTH and endothelin-1, 2) of total alpha-aminonitrogen and cGMP was studied in rat blood. The data obtained suggest that NO2- may be involved in regulation of these physiologically active substances because NO2- are the deposited form of nitric oxide which may regulate the inter- and intracellular signal systems.

Animals↗
PubMedDate not supplied

[Status of hypothalamic dopamine receptors in spinocerebellar degenerations].

The sensitivity of hypothalamic dopaminergic D2-receptors was studied in 52 patients with various spinocerebellar degenerations (SCD). Radioimmunoassay of blood prolactin enabled the state of these receptors to be evaluated before and after loading with D2-receptor agonist (bromocriptine) and antagonist (metoclopramide). In all forms of SCD, the rate of blood prolactin decrease in response to bromocriptine, was significantly lower than control values, which demonstrated the lower sensitivity of D2-receptors in the hypothalamic tubero-infundibular region to agonists. Metoclopramide caused a higher increase in blood prolactin levels than in the controls. The findings suggest that the state of the receptors was altered in SCD patients. A relationship between the impairments found and the clinical and morphological manifestations of different SCD forms is discussed.

Bromocriptine↗
PubMedDate not supplied

[Endorphins and neurotensin in Huntington chorea].

Concentration of alpha-endorphin, beta-endorphin, gamma-endorphin and neurotensin in blood and beta-endorphin in cerebrospinal fluid of 48 patients with various forms of Huntington's disease was measured. Two modifications of immunoassay were used. The level of all neuropeptides studied was significantly decreased. Patients with a kinetiko-rigid form of the disease showed a two-fold lowering in beta-endorphin levels in cerebrospinal fluid in comparison with patients with the classic form. The relationships between these findings and clinical-biochemical characteristics of Huntington's disease are discussed.

Adult↗