[Can randomization create bias?].
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Biomedical subjects
Publications and source records attributed to T S Barfod.
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There is a therapeutic potential in the doctor-patient relationship, in the diagnostic process, and in the symbolic elements of medical therapy. This unspecific effect seems, however, to be mainly caused by the doctor-patient relationship and the diagnostic process, and superfluous investigations and treatments should therefore not be initiated due to an unfounded idea about the potential of the so-called placebo effect. This article tries to identify the unspecific elements in therapy and their therapeutic potential. It is pointed out, that the outcome of a treatment is a sum of the effect of the relationship between the physician and the patient, plus the specific biological treatment effect, plus the incidental effect including the effect of the patients knowledge of being under treatment. The article asks for more research in the first and the last of these three components of therapy.
Strict compliance is required for a sustained response to antiretroviral therapy for HIV. Several studies from the US have found that African-Americans are less compliant and are more liable to treatment failure than caucasians. We describe a young, male refugee from Africa with treatment failure after non-compliance. A qualitative interview shows that his main reason for non-compliance is fear of disclosure and stigmatization. There seems to be a need for research into the reasons for non-compliance among vulnerable groups and targeted interventions.
Mycoplasma pneumoniae infection is sometimes followed by systemic reactions such as erythema multiforme major/Stevens-Johnsons syndrome. In the described case, a 30 year-old man developed severe inflammation of the oral mucous membranes following respiratory infection with Mycoplasma pneumoniae. There was also conjunctivitis and diarrhoea, and a target-like eruption was seen on the penis, but apart from slight perioral erythema and periorbital swelling, no further skin involvement was seen. The patient was treated with macrolide antibiotics for 14 days and gradually recovered.
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