Oral hairy leukoplakia.
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Herpesvirus 4, Human↗
Biomedical subjects
T Rufli
Publications and source records attributed to T Rufli.
Congenital hypertrophy of the lateral nail folds of the hallux.
A case of a 7-month-old boy with bilateral symmetrical congenital hypertrophy of the lateral nail folds of the hallux is described. The body showed no other skin symptoms. The types of ingrowing nails in infancy are discussed. A partial remission of the disease after 1 year was observed.
Hallux↗
Localized unilateral hyperhidrosis.
We describe a case of localized unilateral hyperhidrosis on the forehead in a 52-year-old woman. The pathophysiology of this unique clinical picture and its treatment are described.
Female↗
[Ross syndrome].
We report on a 25-year-old patient with hyporeflexia, progressive segmental hypohidrosis and dry, scaly skin mimicking tinea manuum on the affected palm. This case is the fourth with Ross syndrome and skin manifestations as a result of segmental hypohidrosis.
Adult↗
Adverse skin reactions to nicotine in a transdermal therapeutic system.
Nicotine in a transdermal therapeutic system (TTS) has been introduced recently to help people to stop smoking. 14 volunteers (10 male, 4 female) with a history of former adverse skin reactions to this device were investigated. Skin tests for contact urticaria and patch tests for contact allergy were done with the individual components of the TTS. Contact sensitization to nicotine was identified in 5 and to the TTS itself in 1 individual. Irritant reactions due to occlusion were present in 9 subjects. The optimal test agent and concentration for elucidating the adverse skin reaction was an aqueous solution of 10% nicotine base. Atopy, as diagnosed by history and skin prick tests to common inhalant allergens, and contact sensitization to standard patch test allergens, were each identified in 6 subjects. Nicotine should be added to the expanding list of transdermally delivered drugs which may elicit contact dermatitis.
Administration, Cutaneous↗
Follicular mucinosis associated with mycosis fungoides.
We report a patient who developed erythematous indurated plaques with alopecia on the face and multiple well-demarcated infiltrated scaling lesions on the trunk and extremities. Skin biopsy showed a mucinous degeneration of the follicular outer root sheaths and sebaceous glands consistent with the diagnosis of follicular mucinosis. A histologic examination of a specimen from the left forearm showed microscopic changes of mycosis fungoides. The present case confirms the need of multiple skin biopsies in the evaluation of patients with follicular mucinosis.
Aged↗
Tumor of follicular infundibulum.
Tumor of the follicular infundibulum is a rare, benign proliferative follicular disorder. A case of multiple lesions in a 37-year-old woman is reported. The diagnosis was made histologically.
Adult↗
[Oral hairy leukoplakia in patients with kidney transplantation].
Oral hairy leukoplakia was initially reported only in HIV-infected patients and was considered pathognomonic for HIV infection. The presence of Epstein-Barr virus and the decrease in Langerhans cells seem to be necessary for the development of oral hairy leukoplakia. HIV antigen is not present in oral hairy leukoplakia. We report on seven renal transplant recipients with oral hairy leukoplakia. In six of these patients no HIV infection was present. All patients showed marked immunosuppression following a vigorous immunosuppressive regimen. Five patients each had several rejection episodes, which were treated with further immunosuppressive therapy in addition to the basic immunosuppressive regimen. One patient was infected with HIV from the renal graft and another suffered from liver cirrhosis with portal hypertension caused by chronic hepatitis B infection. We believe that oral hairy leukoplakia is a marker for severe immunosuppression that is not necessarily associated with HIV infection. Organ transplant recipients undergoing dermatological check-up should be examined for oral hairy leukoplakia.
Adult↗
[Morphaea profunda].
A 47-year-old woman with a solitary morphoea profunda on the flexor aspect of the left thigh is described. Clinically the lesion is characterized by a circumscribed, deeply indurated sclerotic plaque. The main histopathological features were sclerotic collagen changes and a striking accumulation of inflammatory cells in the deep dermis as well as in the subcutaneous tissue. Plasma cells and T- and B-lymphocytes were the predominant cellular components of the infiltrate. The patient had an elevated serum titre of antibodies to Borrelia burgdorferi. The patient was treated with penicillin, which brought about a remarkable improvement. These findings provide further support for the concept that in some cases morphoea profunda may be a manifestation of Borrelia infection.
Antibodies, Bacterial↗
[Non-bullous erythroderma (congenital) ichthyosiforme with perinuclear shells].
A congenital dermatosis with an unusual course is described in a 5-year-old girl. During the first months of life she was found to have erythrokeratodermatic plaques, which developed into a non-bullous (congenital) ichthyosiform erythroderma (CIE) within 1 year. Since then, the clinical picture has remained stable. Histologically, the upper epidermal layers showed ballooning and vacuolization of the keratinocytes, glycogen storage, and focal parakeratotic keratinization. Conspicuous ultrastructural alterations consisted in the formation of shells of fine-filamentous, cross-linked material of unknown nature, binuclear keratinocytes, perinuclear edema formation, and the occurrence of lipid droplets in the horny layer. The n-alkane value was within the normal range. Our histological and ultrastructural findings are largely in accordance with those in a case of "congenital reticular ichthyosiform erythroderma". The disorder seems to represent a special genotype in the heterogeneous group of the non-bullous CIEs. We suggest naming it "non-bullous (congenital) ichthyosiform erythroderma with perinuclear shells".
Cell Nucleus↗
Syphilis and HIV infection.
Treponema pallidum and HIV are both sexually transmitted agents of infectious diseases with epidemiological similarities. Ulcerous genital diseases such as primary syphilis facilitate transmission of HIV. An increasing number of case reports gives evidence that in HIV-infected patients secondary syphilis runs a more severe course and may present as syphilis maligna and that neurological complications of secondary and tertiary syphilis seem to occur more frequently and at an earlier stage. The clinical evaluation, interpretation of serology and choice of treatment schedules must take these considerations into account.
HIV Infections↗
[First experience with retinoid acid derivative Ro 10-9359 in the treatment of viral epithelioma].
Two patients with extensive verrucae plantares have been treated successfully with the retinoic acid derivative Ro 10-9359. Both patients were practically unable to walk due to widespread involvement of the plantae pedium. In a second series of 12 patients with verrucae vulgares this form of therapy produced unsatisfactory results. In 2 further patients with verrucae plantares healing was achieved in one, and also in a patient with verrucae planae. A patient with verrucae periunguales did not react to the treatment. The dosage was gradually increased to above the normal value of 1.0 mg/kg body weight per day, according to individual tolerance. The aim was to reach a dose of over 1.5 mg/kg body weight per day. The side effects were therefore impressive and interruption or termination of therapy was often necessary. However, new side effects have not been observed with this high dosage and this new indication, apart from psoriasiform dermatitis and an intermittent vegetative disturbance, the latter without clear evidence of a causal relation to the Ro 10-9359 medication. Pathological liver values have not been observed. Treatment with retinoid appears to be appropriate in cases with verrucae plantares, especially where conventional methods do not prove satisfactory.
Adolescent↗
[Dermatoloical entomology. The practical-medical importance of mites and insects in Switzerland and surrounding regions. 3. Heteroptera/bugs].
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Bedbugs↗
[Anoplura/sucking lice (author's transl)].
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Anoplura↗
[Siphonaptera/fleas (author's transl)].
Fleas are small, reddish-brown, wingless insects with a laterally compressed body and a pronounced third pair of legs adapted to leaping. Of the 100 species found in Middle Europe, hardly a dozen are of medical importance, they concern mainly people in contact with domestic animals. The cat flea, Ctenocephalides felis felis, and the bird flea. Ceratophyllus gallinae, are the most important human-pathogenic species in our region. A flea bite shows first as a haemorrhagic punctum, accompanied by itching, and leads to an erythema with or without central wheal. After 12--24 hours a papule appears which persists up to 2 weeks. Linimentum zinci with 10% Neocid alleviates the itching and prevents further infestation. The fleas are destroyed in their hiding places and on their animal host by applying Toxical-, Neocid- or Noflo-powder. The tropical sand flea, Tunga penetrans, is a permanent ectoparasite of man. It is seen in people returning from the tropics. Fleas may, even in our region, be vectors of bacteria, viruses, rickettsiae and intestinal parasites.
Adult↗
[Congenital, self-healing reticulohistiocytosis].
The described skin condition is characterized by multiple congenital skin tumours and disseminated papules on the trunk, which regressed without therapy during the first two months of life. Apart from the skin, no other organs were involved. The histological examination showed a histiocytic infiltrate composed of cells with large, irregularly formed nuclei and partly opaque, foamy cytoplasm. Extravasation of erythrocytes was frequent. The skin disorder is similar to the congenital self-healing reticulohistocytosis of Hashimoto and Pritzker.
Female↗
Antibiotic sensitivity of gonococcal strains isolated from patients in Basel and environs.
During the first 4 months of 1977, 95 different strains of gonococcus were isolated in the out-patient department of the Dermatology Clinic of the University of Basel. These were systemically tested for sensitivity to penicillin G, spectinomycin, thiamphenicol, doxycycline and rifampicin. The MIC values and the diameter of the zones of inhibition were determined. Tests for beta-lactamase production were made. A correlation in the degree of sensitivity was observed between the following antibiotics: penicillin G/rifampicin; penicillin G/thiamphenicol; penicillin G/doxycycline; thiamphenicol/doxycycline; thiamphenicol/rifampicin; doxycycline/rifampicin. The size of the inoculum had little influence on the activity of the substances, except for that of penicillin G against the beta-lactamase-positive reference strains. No beta-lactamase-producing strains were detected amongst the clinical isolates. In the case of penicillin G, there was a correlation between the minimum inhibitory concentration and the inhibition-zone diameter.
Anti-Bacterial Agents↗