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Biomedical subjects

T Riordan

Publications and source records attributed to T Riordan.

At least 37 records · Page 2Linked to original sources
PubMed1990

A prospective study of genital infections in a family-planning clinic. 1. Microbiological findings and their association with vaginal symptoms.

A prospective study of genital infection was conducted in four inner-city family-planning clinics. Fifteen per cent of routine attenders had symptoms and signs of vaginal infection and many more women attended primarily because of symptoms. Among the women with both signs and symptoms, 70% had positive laboratory findings, Trichomonas vaginalis, Candida albicans and bacterial vaginosis being equally prevalent. Measurement of vaginal pH in the clinic was the single most useful clinical finding for directing empirical therapy. Among patients with a discharge confirmed on examination and an abnormally high pH, 72% had either T. vaginalis or bacterial vaginosis. Neisseria gonorrhoeae was isolated from 4% of women with, and 1% of those without, symptoms. We believe that it is worthwhile to investigate patients presenting to family-planning clinics with vaginal symptoms. No single specimen was found ideal for all pathogens, a cervical swab is better for gonococci and also for T. vaginalis but a vaginal swab is needed for candida and bacterial vaginosis.

Bacterial Infections↗
PubMed1990

A prospective study of genital infections in a family-planning clinic. 2. Chlamydia infection--the identification of a high-risk group.

During a study of genital infection in inner-city family-planning patients we examined 452 women for Chlamydia trachomatis. The prevalence of infection was 7.3%. There was no significant difference between patients attending because of genital symptoms and those who were attending for routine family-planning advice. Infection was found to be correlated with five main demographic parameters; age less than 25, no stable partnership, hormonal contraception, nulliparity and West Indian Ethnic origin. Using these parameters a simple scoring system was devised which allowed a high-risk population to be defined in whom screening would be economically justified.

Adult↗
PubMed1989

Secondary cases of meningococcal infection among close family and household contacts in England and Wales, 1984-7.

To determine the incidence of secondary meningococcal infection in close family and household contacts of index patients and to review the efficacy of chemoprophylaxis the records of 3256 cases occurring from 1984 through 1987 were examined. Seventeen secondary cases (0.5%) of infection were identified among these groups. The median interval between index and secondary cases was seven weeks. Fourteen secondary cases occurred more than one week after the disease was diagnosed in the index case. Three secondary cases had not received chemoprophylaxis and in another case the infecting strain had acquired resistance to rifampicin. Prophylaxis for the close contacts of 10 out of 11 of the remaining index patients failed to fulfil all the criteria of an optimal regimen. Even after optimal chemoprophylaxis the medical practitioner and the family should be aware of the increased and prolonged risk of secondary meningococcal infection among close contacts of patients with the disease.

Adult↗
PubMed1988

Diphtheria--the continuing hazard.

An unimmunized schoolchild with no history of foreign travel developed severe diphtheria. Epidemiological investigations led to the discovery of a child in the same class with cutaneous diphtheria who had just returned from Bangladesh; this highlights the importance of swabbing all skin lesions acquired in endemic areas during any outbreak investigation.

Child↗
PubMed1986

An outbreak of gastroenteritis in a psycho-geriatric hospital associated with a small round structured virus.

An outbreak of gastroenteritis in a psycho-geriatric hospital is described. Small round structured viruses, morphologically similar to Norwalk agent, were seen in stool samples from four patients. Although the illness was mild, 67 patients and 30 nurses on four wards were affected over a period of 4 weeks. Because of shortage of staff and isolation facilities, difficulty was experienced in introducing effective control measures.

Aged↗
PubMed1985

An outbreak of food-borne enterotoxigenic Escherichia coli diarrhoea in England.

An outbreak of diarrhoea with abdominal pain occurred among members of the staff of a school and their guests after a social function at which a cold buffet was served. Sixty people attended the function and 43 subsequently completed questionnaires. Of these, 27 had diarrhoea. The median incubation period was 36 h and the range 12-66 h. Food history analysis showed an association between diarrhoea and eating curried turkey mayonnaise. Stool specimens from 13 of those who developed diarrhoea were examined: Escherichia coli 06.H16 (producing heat-stable and heat-labile enterotoxins) was found in nine specimens and E. coli 027.H20 (producing heat-stable enterotoxin) in 11 specimens. Eight patients had both strains and only one was negative for enterotoxigenic E. coli. Food samples were not available for examination. Enterotoxigenic E. coli should be considered as a possible cause in well-defined outbreaks of food-borne diarrhoea with abdominal pain.

Abdomen↗
PubMed1984

Food borne infection by a Norwalk like virus (small round structured virus).

Two outbreaks of gastrointestinal illness with identical symptoms occurred in parties attending banquets on consecutive evenings at a large hotel. The illness was typical of epidemic winter vomiting disease. Small round structured viruses resembling those seen in the Norwalk Ohio outbreak were identified by electron microscopy in stools of victims from one episode. One food handler was found to be excreting the virus, and there was evidence of a poor standard of hygiene in the kitchen. A food history analysis showed the illness to be significantly associated with eating cold cooked ham.

Disease Outbreaks↗
PubMed1983

Demonstration of an immune-mediated mechanism of penicillin-induced neutropenia and thrombocytopenia.

Severe neutropenia may be a more common complication of high-dose penicillin therapy than previously recognized. This report describes five such patients, one of whom also had thrombocytopenia. The neutrophil and platelet counts rapidly increased on stopping penicillin, and the bone-marrow, which was hypocellular in some cases, became normal. Further studies on one of these patients, using a fluorescent antiglobulin technique with paraformaldehyde-fixed cells, demonstrated a complement-fixing IgG penicillin antibody reacting with the patient's granulocytes and platelets in the presence of the drug. This suggested an immune mechanism similar to the well-recognized penicillin-induced immune haemolytic anaemia. The associated bone-marrow hypoplasia may also be due to antibody-mediated suppression of penicillin-coated precursor cells.

Adult↗