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T Reunala

Publications and source records attributed to T Reunala.

At least 217 records · Page 12Linked to original sources
PubMed1978

Gluten-free diet in dermatitis herpetiformis. II. Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls.

Twelve patients with dermatitis herpetiformis whose skin condition responded to a gluten-free diet (GFD) were re-examined after diet treatment. The findings were compared with those in matched patients on a normal diet. Jejunal histology revealed morphological improvement in every patient on a GFD whereas all patients on a normal diet continued to have villous atrophy. Intra-epithelial lymphocyte counts were normal in 8 patients on a GFD in contrast to one on a normal diet. Immunofluorescence examination of the jejunal mucosa revealed that the numbers of cells containing IgA and IgM were increased significantly in the normal diet group. The figures were lower in the GFD group but these also exceeded the values in the controls. IgA deposits were found in the uninvolved skin of every patient irrespective of the diet treatment, but the fluorescence seemed to be less intense in patients on a GFD. A clear difference was found in the occurrence of C3 deposits in the uninvolved skin. Three patients on a GFD had C3 deposits; two of these did not follow a strict diet. However C3 was found in 8 patients on a normal diet. Circulating dietary and auto-antibodies were found in two patients on a GFD and in 9 on a normal diet. Serum immunoglobulin (IgG, IgA, IgM) and complement (C3, C4) levels were within normal limits in both patient groups.

Adult↗
PubMed1978

Dermatitis herpetiformis in Finland.

During a 3 1/2-year period, 492 patients with dermatitis herpetiformis (DH) visited the dermatological departments of Finnish hospitals. The prevalence of DH in Finland was 10.4 patients/100,000 inhabitants, or 1/10,000. About 60 patients contracted DH each year, giving an incidence of 1.3 patients/100,000 inhabitants/year. These figures show that DH is a rather common disease in Finland--much more so in Finland than in Britain. Its incidence does not differ much from that approximated for coeliac disease in Finland. DH occured in all parts of the country. The birth-places of the patients were distributed evenly over the whole country, in contrast to the distribution pattern of rare hereditary diseases in Finland. No significant difference was found in the occurrence of DH in areas with differing levels of wheat consumption or iodine intake.

Adolescent↗
PubMed1977

Immunoglobulin e-mediated severe allergy to human seminal plasma.

Two women with allergy to human seminal plasma are described. Both patients had generalized and local allergic symptoms, i.e., hypotension, asthmatic dyspnea, urticaria, and vaginal swelling, beginning within a few minutes of intercourse. The antigen causing the reaction in these patients was common to all seminal plasmas examined. Most of the antigenic activity was shown to be present in one protein band detected by acrylamide gel electrophoresis. The seminal plasma reaction was mediated through an immunoglobulin E (IgE) antibody. Passive transfer of the hypersensitivity with the serum of both patients was successful, and the radioallergosorbent test showed that the serum of the first patient contained IgE specific to seminal plasma.

Adult↗
PubMed1977

Herpes gestationis. A high titre of anti-HLA-B8 antibody in the mother and pemphigoid-like immunohistological findings in the mother and the child.

A mother with herpes gestationis and her child without cutaneous lesions had analogous immunohistological findings. In the skin they had deposits of IgG and C3 component of complement at the basement membrane zone. Circulating IgG antibody to the basement membrane was also demonstrated in both. The mother also had a high titre of anti-HLA antibody against a histocompatibility antigen (HLA-B8) present in the child. A possible role of this HLA antibody in the pathomechanism of herpes gestationis is discussed.

Adult↗
PubMed1977

Gluten-free diet in dermatitis herpetiformis. I. Clinical response of skin lesions in 81 patients.

Eighty-one patients with dermatitis herpetiformis were treated with a gluten-free diet (GFD) for periods varying from 6 to 36 months. At the end of the treatment the daily requirement of dapsone was significantly lower in patients treated with a GFD than in 49 patients on a normal diet. 93% of the patients on a GFD were able to reduce the dose of dapsone whereas only 16% of the patients on a normal diet were able to do this. Complete remissions occurred only in patients on a GFD. 28% of the patients on a GFD were able to stop dapsone completely and were continuously asymptomatic when they observed a strict diet. A response to a GFD was noted on the mean daily requirement of dapsone as soon as the treatment was initiated although the length of time for an individual response varied. After one year on a GFD the patients needed on average about 40% and after 3 years about 20% of the dose required to control skin symptoms at the beginning of the diet. The patients responded to a GFD irrespective of changes found in the jejunal mucosa and irrespective of the presence of absence of HLA-B8.

Adolescent↗
PubMed1977

[Sperm allergy].

Explore the source record for details and available documents.

Contraceptive Devices, Male↗
PubMed1976

Histocompatibility antigens and dermatitis herpetiformis with special reference to jejunal abnormalities and acetylator phenotype.

Sixty-one patients with dermatitis herpetiformis (DH) were studied. Of these fifty-three (87%) had the histocompatibility (HL-A) antigen HL-A8 as compared with 17% of a control population; the difference is significant. This incidence of HL-A8 among patients with DH is higher than that reported earlier for such patients and is similar to that reported for patients with adult coeliac disease. The incidence of HL-A1 was also significantly greater in the patient group, and was attributed to the increased frequency of haplotype HL-A1, 8. The frequency of HL-A8 was about equal in patients in whom DH was associated with jejunal abnormalities and in those in whom it was not. When correlated with rate of acetylation, there was no significant difference in the occurrence of various HL-A antigens.

Acetylation↗
PubMed1976

Family studies in dermatitis herpetiformis.

Six families were studied which included 11 members with dermatitis herpetiformis (DH) and three with coeliac disease (CD). Proximal jejunal biopsies performed on 20 relatives revealed villous atrophy in eight. Of these eight, two, both siblings of patients with DH, had a history of juvenile CD. Determinations of histocampatibility (HLA) antigens showed that HLS-B8 occurred in all six families although two patients with DH and one relative with a history of juvenile CD lacked this antigen. In one family the haplotype A1,B8 was associated with DH, villous atrophy, juvenile diabetes and Addison's disease. Skin biopsy failed to reveal IgA in any of the 44 relatives studied for this immunoglobulin. Antireticulin antibody was detected in the sera of seven (17%) relatives.

Adolescent↗
PubMed1975

Circinate erosive balanitis and HL-A 27.

The HL-A phenotype of 17 patients with a typical clinical picture of circinate erosive balanitis was determined. Eight of the patients had other signs of Reiter's disease and 9 had balanitis alone. HL-A 27 was found to be present in 15 of the 17 cases. One patient of each group lacked this antigen. The frequency of the other histocompatibility antigens did not significantly differ from that of a Finnish control population.

Adolescent↗
PubMedDate not supplied

Antigliadin and antireticulin antibodies in children with dermatitis herpetiformis.

The serum samples of 27 children with dermatitis herpetiformis (DH) were examined for the presence of antigliadin (AGA) and antireticulin (ARA) antibodies. AGA were determined with an enzyme-linked immunosorbent assay (ELISA) and ARA with an immunofluorescence method. Increased IgA or IgG class AGA levels were found in four of ten children on a normal diet, in two of 25 on a gluten-free diet (GFD), and in two of four children on gluten challenge. The corresponding figures for ARA were nine of ten, two of 25, and four of four, respectively. All nine patients with ARA on a normal diet had either subtotal or partial villous atrophy, whereas the patient negative for ARA had a normal jejunal mucosa. ARA were mostly of IgA class, and after gluten withdrawal, increased levels fell to normal range. Four children were challenged with gluten, and they all developed subtotal villous atrophy and demonstrated IgA class ARA. These results suggest that in childhood DH, ARA is a more sensitive indicator of gluten-sensitive enteropathy than AGA, but both antibody determinations can be used in monitoring adherence to GFD treatment.

Adolescent↗
PubMedDate not supplied

Detection of IgG4 and IgE antibodies to rubber proteins by immunoblotting in latex allergy.

Sera from four latex-allergic hospital employees (two physicians and two nurses) were examined for the occurrence of IgG4 and IgE antibodies to rubber proteins by immunoblotting. We used natural rubber sap as antigen source and detected IgG4 antibodies in all four patient sera. The IgG4 antibodies bound to 12 rubber protein antigens with molecular weights ranging from 14 kD to 53 kD. IgE antibodies bound nine of the antigens and the major antigen for both IgG4 and IgE seemed to be a 21 kD rubber protein. The parallel occurrence of IgG4 and IgE antibodies against the same rubber protein antigens suggests that IgG4 antibodies also may play a role in the pathogenesis of latex allergy.

Antigens↗