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Biomedical subjects

T Reisner

Publications and source records attributed to T Reisner.

52 records · Page 3Linked to original sources

The diagnosis of cerebral atrophy on the basis of cerebral angiogram.

An increased distance between brain surface, represented by the terminal arterial branches, and skull causes the appearance of a broad avascular band in the carotid angiogram, which--apart from other criteria--has been valued as a sign of cerebral atrophy. We investigated 54 patients (ages 60-79 years) suffering from cerebrovascular disease. Carotid angiographies of the afflicted hemispheres were carried out within 4 to 90 days after the stroke. The distance between vessels and skull was measured in frontal and lateral projection. We evaluated statistically the impact on this distance of alterations in extracranial vessel walls, number of attacks, severity of stroke, and patient's age. The results are compared to those of CAT. Only limited correlations have been found between the above-mentioned parameters and the distance between vessels and skull. Thus the distance is only of limited diagnostic value for the verification of senile cerebral atrophy on a vascular basis.

Aged

[Conventional contrast media examinations and computer tomography in space-occupying processes (author's transl)].

In 1977, more than 2,000 patients were examined in our department of neuroradiology by means of angiography, computed tomography, and in some cases also by pneumoencephalography. The value of the various neuroradiological examinations is discussed taking as an example two patients suffering from intracranial space-occupying processes of different etiologies. Consequently, the differential diagnostic problems occurring are discussed casuistically. It is demonstrated that correct diagnosis can often be achieved only by use of all the results of the different neuroradiological methods, together with precise knowledge of the course and the clinical symptoms.

Aged

[Angiocinematography of cerebral circulatory disturbances using angiografin (author's transl)].

The arterial flow rate in the three superficial groups of branches of the middle cerebral artery was determined angiocinematographically in 37 hemispheres of 24 patients. In 10 hemispheres of patients with cerebrovascular diseases the arterial flow rate in the corresponding group of branches was lowered to a statistically significant extent. The importance of the choice of contrast medium is emphasized and that used in our investigations, Angiografin, dealt with in more detail. The diagnostic value of conventional determination of cerebral circulation time from serial angiograms is questioned and compared with the results of angiocinematographic investigation.

Adult

Long-term prognosis in stroke related to cerebral blood flow.

In 180 patients, cerebral blood flow was measured between one and six weeks after acute cerebrovascular ischemia. Patients were grouped according to their clinical deficits at the time of blood flow study. Statistical analysis revealed highly significant differences among the flow values of the groups. The patients were followed up for a period of up to 6 years (mean, 34 months) after the attack, and then regrouped. In these groups, the statistical significances of differences among the flow values was even higher. Patients also were grouped according to changes in neurologic status, and again the flow values differed significantly among the groups. The results show significant relationships among flow values after cerebrovascular ischemia and neurologic deficits, change in status, and the final functional state. Cerebral blood flow measurement together with other clinical signs permits an estimation of a patient's chance for functional recovery after a stroke.

Adolescent

[Subacute encephalitis during lactation (author's transl)].

Two cases of encephalitis during lactation are reported. The illness started with psychotic symptoms and some weeks later neurological disturbances appeared. The course of the illness was subacute and both cases the brain scan was abnormal with numerous nodules. A CSF proteinogram showed an acute phase reaction, pointing to an organic lesion of the nervous system, but no impairment of the blood CSF barrier and normal immunoglobulin G levels. The possible aetiological factors, as well as the CSF and brain scan findings are discussed.

Acute Disease

[Traumatic cerebral thrombosis (author's transl)].

The observation of 6 patients with traumatic cerebral thrombosis following closed injury to the skull stimulated this compilation and review of the relevant literature on this subject. Thrombosis of the internal carotid artery and the vertebral artery head the list and do not only come about after blunt trauma to the neck, in which case traumatic aetiology is always thought of in conjunction with the appearance of appropriate neurological symptoms, but also arise from injuries to the skull. In the latter circumstances, the cerebral symptoms will usually be attributed to an epidural or subdural haematoma, particularly if there is a symptom-free period. This happens especially after minor injuries to the skull. In fact, traumatic thrombosis is seen less frequently than extracerebral haematomas, but is nevertheless repeatedly encountered owing to the great number of traffic accidents. Definitive diagnosis can be made only by angiography of the cerebral vessels, above all of the internal carotid artery. Similar to the prognosis of any disease caused by vascular occlusion, the prognosis as to the extent of recovery from the cerebral focal symptoms depends on the sufficiency of the collateral circulation, whereby surgical removal of the thrombus at the earliest possible moment appears to absolutely indicated.

Carotid Artery Thrombosis

[Thrombosis of the cerebral vessels following closed cranial trauma (author's transl)].

The case histories are presented of 6 patients, 5 of whom developed carotid artery thrombosis (the left vessel being affected in 4 cases and the right only in 1 case) following closed cranio-cerebral trauma; the 6th patient developed thrombosis of the posterior cerebral artery, as confirmed at autopsy. The factors involved in the aetiology of these events are discussed on the basis of the case reports.

Accidents, Traffic

[Effect of Ouabain on cerebral blood flow (author's transl)].

The effect of 0.25 mg ouabain on cerebral blood flow (CBF) was investigated in patients with and without cerebrovascular disease using the xenon clearance method. The 36 patients included in this study did not show any signs of heart failure. Ouabain increased the CBF and this effect was demonstrable 15, as well as 90 min. after administration. This effect was proven statistically using the t-test for a comparison of the values with spontaneous changes in a control group without medication. The perfusion of pathologically-supplied brain regions was altered in the same way as the hemispheric flow; changes in the distribution of blood in the way of a steal effect were not observed. The haemodynamic parameters do not indicate a primary cardiac effect. Hence, an influence of ouabain on cerebral vessels might be responsible. The present results support reported clinical experience with ouabain for the treatment of patients with cerebrosvascular disease.

Blood Pressure

[Transverse lesion of the cord syndrome in chondrodystrophic dwarfs (author's transl)].

More than 70 transverse lesion of the cord syndromes in chondrodystrophic dwarfs have been described in the literature. 43 of these were adequately described and/or accessible for the authors. In 22 cases, a mechanical cause (including 14 lesions of the intervertebral disk) was directly responsible and, in 14 cases, no direct spinal cord suppression was found. In the latter group, 10 had a negative myelography, 3 positive and 1 case myelography was not performed. Of the 12 laminectomized cases, only 3 made a good recovery, 4 showed severe deterioration and 2 conservatively treated cases (including the case described here) were clearly improved. Of the 16 laminectomized cases with limited mechanical impediment, 8 showed good results, 3 indifferent and 5 unknown. The cause of the vascular myleopathy was assumed to be a combination of the narrowness of the bony vertebral canal and an increasing kyphotic process. The authors suggest that laminectomy for tranverse lesion of the cord syndrome in dwarfs should be made only after several controls and an established stop correlating with the location of the neurological lesions. We reject decompression laminectomy for vascular myleopathy because of the already endangered vascular situation and the poor results. We prefer orthopedic measures.

Achondroplasia