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Biomedical subjects

T Reed

Publications and source records attributed to T Reed.

At least 127 records · Page 7Linked to original sources

Fingerprint pattern factors.

Factor analysis was employed using the ulnar ridge count, radial ridge count, ridge count (the larger of the radial or ulnar count as generally used for calculating total ridge count), and pattern type for each finger in 720 twins. Pattern type and ulnar count displayed parallel factor loadings while loadings for radial and ridge count also paralleled each other. This relationship did not hold for the index finger, indicating the importance of pattern direction and greater pattern diversity for this digit. Total ridge count was most closely associated with a factor of ring and little finger radial and ridge count and only secondarily with an index finger factor. When radial and ulnar counts were deleted to make comparisons with earlier studies, the result was factors having groupings of variables identical with previous reports. It appears that factor analysis results in consistent extraction of identical or very similar factors from different populations, and the use of radial and ulnar counts adds more information than when only the larger of the two counts is considered.

Dermatoglyphics↗

Outcome research on treatment and on the drug abuser: an exploration.

The study of treatment outcome has its own history, and the experience of other service fields in this area may be of considerable interest to researchers concerned with the effectiveness of treatment for drug abusers. Methodological issues that emerged from psychotherapy's efforts at self-evaluation are reviewed and contrasted with work done on treatment outcome in drug programs. An overview is presented of current research on the improvement of drug abusers and on treatment effectiveness.

Age Factors↗

Comparisons of dermatoglyphic patterns in monochorionic and dichorionic monozygotic twins.

The data presented here indicate that different influences affect dermatoglyphic pattern development in MC-MZ and DC-MZ twins. Only five of 84 variables had significant mean differences but their clustering suggested a real difference in mean placement of the atd angle. Nineteen of 84 variables had significantly different within-pair mean squares for the two twin types. Larger numbers of twins will be required to obtain accurate estimates of the magnitude of the dermatoglyphic differences between MC-MZ and DC-MZ twins. Studies of dermatoglyphics in MC-MZ and DC-MZ twins are important to the understanding of factors which influence early embryonic development and when better documented may provide a mechanism for retrospectively diagnosing placental type of MZ twins.

Chorion↗

Duffy blood group and hemoglobin variants.

Data on a sample of 809 Afro-Americans indicated that there is no association between Duffy null (a-,b-) blood type and sickle cell trait. The results further rule out close linkage as an alternative hypothesis to explain the reported association between these loci in areas where falciparum and vivax malaria are endemic and indicate that, even if the two loci are independent or loosely linked, direct evidence of the selection favoring AS Fy-Fy- individuals must come from populations where mixed malaria infections occur. Stratification, as an explanation for the reported association, is also discussed.

Black People↗

Dermatoglyphic differences between 45,X and other chromosomal abnormalities of Turner syndrome.

The dermatoglyphic findings in 87 patients with Turner syndrome are summarized. Comparisons are made between the 50 cases with 45,X karyotypes and the remaining 37 with different chromosomal abnormalities including 19 patients with an X long arm isochromosome cell line. The results indicate differences between the 45,X patients and the other chromosomal types which are in the same direction as the changes reported between Turner syndrome and normal controls.

Adolescent↗

X-linked skeletal dysplasia with mental retardation.

A syndrome compatible with an X-linked trait is described, affecting four male cousins in three sibships. The body had skeletal anomalies, including short stature, ridging of the metopic suture, fusion of cervical vertebrae, thoracic hemivertebrae, scoliosis, sarcral hypoplasia and short middle phalanges. In addition, they had moderate developmental retardation, and abducens palsies. Three of the four had glucose intolerance, and one was born with an imperforate anus. Of five female obligate carriers studied, three had fusion of cervical vertebrae, three had some shortening of the middle phalanges and three had glucose intolerance. The syndrome in this family was compared to previously reported syndromes, and the conclusion was reached that it represents a previously unreported X-linked syndrome with minor manifestations in carrier females.

Abnormalities, Multiple↗

A comparison of the dermatogram with other indices for the diagnosis of Down's syndrome.

The Dermatogram, a dermatoglyphic nomogram based upon four pattern areas, was compared with three other indices for the diagnosis of Down's syndrome (D.S.). The measure of diagnostic accuracy used was the percentage of patients scoring outside reported overlap scores between normal and D.S. The Dermatogram correctly diagnosed 79% of 119 D.S. patients. Two other indices, using more pattern areas and requiring calculations, correctly diagnosed more patients (81 and 87%), but one had several incorrect diagnoses and the other was less efficient when scored on a small sample of normal, karyotyped, non-D.S. retardates. The Dermatogram is suggested for use as a rapid diagnostic screen. For patients in the Dermatogram overlap, added discrimination may be obtained from secondary scoring on other indices.

Dermatoglyphics↗

A dominant syndrome of metacarpal and metatarsal asymmetry with tarsal and carpal fusions, syndactyly, articular dysplasia and platyspondyly.

A mother and daughter with metacarpal and metatarsal asymmetry, tarsal and carpal fusions, long bone articular dysplasia and platyspondyly are reported as a possible autosomal dominant syndrome affecting skeletal development. The asymmetry of the second metacarpals is perhaps the most striking finding and resulted in a range of bone lengths in the two individuals from minus 6.3 to plus 3.7 standard deviations from the mean.

Abnormalities, Multiple↗

Genetic analysis of dermatoglyphic patterns in twins.

Analysis of variance was performed on 71 dermatoglyphic variables in 424 twin sets. Using a method of twin analysis estimates of genetic variance were obtained. 54 of the variables were quantitated using a scoring system with modifications of arch or no pattern = 0, loops = 1, whorl = 2. The results indicated a significant genetic influence in most pattern areas. Patterning was more genetically controlled in the hand than in the foot. The hallucal area had the most significant genetic component of the foot while the patterns in the thumb had nonsignificant components of genetic variance. The thumb deviated from patterning in the rest of the fingers and may be more closely related to big-toe patterning.

Dermatoglyphics↗