Biomedical subjects

T Rayner

Publications and source records attributed to T Rayner.

15 recordsLinked to original sources

PubMed2006

ArrayExpress--a public database of microarray experiments and gene expression profiles.

UNLABELLED: ArrayExpress is a public database for high throughput functional genomics data. ArrayExpress consists of two parts--the ArrayExpress Repository, which is a MIAME supportive public archive of microarray data, and the ArrayExpress Data Warehouse, which is a database of gene expression profiles selected from the repository and consistently re-annotated. Archived experiments can be queried by experiment attributes, such as keywords, species, array platform, authors, journals or accession numbers. Gene expression profiles can be queried by gene names and properties, such as Gene Ontology terms and gene expression profiles can be visualized. ArrayExpress is a rapidly growing database, currently it contains data from >50,000 hybridizations and >1,500,000 individual expression profiles. ArrayExpress supports community standards, including MIAME, MAGE-ML and more recently the proposal for a spreadsheet based data exchange format: MAGE-TAB. AVAILABILITY: www.ebi.ac.uk/arrayexpress.

Animals↗

PubMed2005

ArrayExpress--a public repository for microarray gene expression data at the EBI.

ArrayExpress is a public repository for microarray data that supports the MIAME (Minimum Information About a Microarray Experiment) requirements and stores well-annotated raw and normalized data. As of November 2004, ArrayExpress contains data from approximately 12,000 hybridizations covering 35 species. Data can be submitted online or directly from local databases or LIMS in a standard format, and password-protected access to prepublication data is provided for reviewers and authors. The data can be retrieved by accession number or queried by various parameters such as species, author and array platform. A facility to query experiments by gene and sample properties is provided for a growing subset of curated data that is loaded in to the ArrayExpress data warehouse. Data can be visualized and analysed using Expression Profiler, the integrated data analysis tool. ArrayExpress is available at http://www.ebi.ac.uk/arrayexpress.

Animals↗

PubMed1999

High-resolution magnetic relaxation dispersion measurements of solute spin probes using a dual-magnet system.

The magnetic field dependence of the nuclear spin-lattice relaxation rate provides a detailed report of the spectral density functions that characterize the intra- and intermolecular fluctuations that drive magnetic relaxation. We have addressed the difficult sensitivity and resolution problems associated with low magnetic field strengths by using two magnets in close proximity and shielded from each other. The sample is stored in the high magnetic field, pneumatically driven to the variable satellite field, then returned to the high field for detection at high resolution. A magnetic shield effectively decouples the two magnets so that varying the satellite field strength has minimal effect on the field strength and shim of the high field magnet. The disadvantage of the sample-shuttle magnet-pair system is the restriction imposed on the relaxation times by the finite shuttle times. Experiments not described here have shown this rate maximum to be about 20 s(-1) for most practical solutions. However, we demonstrate here that the sensitivity gains over switched-current magnet systems permit characterization of solute inter- and intramolecular dynamics over the time scale range from tens of microseconds to less than a picosecond. This range permits investigation of a number of crucial chemical dynamics questions, while high sensitivity permits examination of a variety of solute spins. Representative data are presented for (1)H, (111)Cd, and (7)Li.

Cadmium↗

PubMed1996

The cardiovascular protective role of docosahexaenoic acid.

Dietary fish oils rich in n-3 polyunsaturated fatty acids can modulate a diverse range of factors contributing to cardiovascular disease. This study examined the relative roles of eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA) which are the principal n-3 polyunsaturated fatty acids regarded as candidates for cardioprotective actions. At low dietary intakes (0.4-1.1% of energy (%en)), docosahexaenoic acid but not eicosapentaenoic acid inhibited ischaemia-induced cardiac arrhythmias. At intakes of 3.9-10.0%en, docosahexaenoic acid was more effective than eicosapentaenoic acid at retarding hypertension development in spontaneously hypertensive rats (SHR) and inhibiting thromboxane-like vasoconstrictor responses in aortas from SHR. In stroke-prone SHR with established hypertension, docosahexaenoic acid (3.9-10.0%en) retarded the development of salt-loading induced proteinuria but eicosapentaenoic acid alone was ineffective. The results demonstrate that purified n-3 polyunsaturated fatty acids mimic the cardiovascular actions of fish oils and imply that docosahexaenoic acid may be the principal active component conferring cardiovascular protection.

Animals↗

PubMed1987

The economic cost of alcohol-related health care in New Zealand.

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Alcoholism↗

PubMed1986

Economics of screening for cancer of the cervix.

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Costs and Cost Analysis↗

PubMed1986

Economic aspects of screening for cervical cancer in New Zealand.

The allocation of scarce health resources to cervical screening indicates that an implicit valuation is being placed on the lives that will be saved. From a model which compares the lives saved with the costs of various screening policies, the valuation of life implied by these policies has been calculated. Screening every three years implies a valuation of life of between $86,000 and $191,000 (1984 prices), which is of a similar order of magnitude to valuations placed on life for other policy purposes. Annual screening would only be appropriate if the valuation of life is $420,000 or over. If screening is to take place at all then it should be done at least every five years. Very infrequent screening cannot be justified because the costs of screening still have to be borne, yet the frequency of detection allows a considerable development of invasive lesions between screenings.

Costs and Cost Analysis↗

PubMed1986

Impact of smoking on health care resource use.

This study examined a sample of almost 1000 women in terms of the impact of cigarette smoking on their experience of various physical conditions and on their use of various health care facilities. Smokers reported more frequent complaints and illness episodes than non smokers. They also made more visits to general practitioners and had more hospital admissions during the 12 months prior to the study. When age groups were examined separately, the differences were found to be more evident amongst the younger groups than the older.

Adolescent↗

PubMed1985

The economic costs to New Zealand of lost production due to alcohol abuse.

This paper estimates the economic cost of lost production in New Zealand due to the abuse of alcohol. Four categories of lost production are examined including excess unemployment amongst abusers, decreased efficiency of abusers in the workforce, temporary withdrawal from the work force due to alcohol induced illness or accident, and permanent withdrawal from the work force due to the premature death of abusers. Assuming full employment, a 4.3% prevalence rate of alcohol abuse, and a 3 : 1 ratio of male to female abusers, the study presents estimates of costs for a range of possible abuser employment levels. The findings indicate that the cost of lost production due to alcohol abuse was between $582 million and $770 million for the 1981/82 financial year. This was equivalent to between 2% and 2.3% of GNP for that year.

Adolescent↗

PubMed1985