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Biomedical subjects

T R Wade

Publications and source records attributed to T R Wade.

30 records · Page 2Linked to original sources
PubMed1979

Intravenous miconazole therapy of mycotic infections.

The efficacy and safety of intravenously administered miconazole nitrate was examined in eight patients with the following infections: cutaneous North American blastomycosis (one), extensive dermatophytosis(one), and chronic mucocutaneous candidiasis (six). Mycologic assessment included direct examination for fungal elements, fungal culture, and histopathology. Laboratory evaluations were performed before and at regular intervals during the study. The total miconazole nitrate dosage, which was administered over a seven- to 32-day period, ranged from 4.0 to 46.8 g. Follow-up examinations extended from two to 15 months. Excellent results were obtained in five patients and fair results in three. No renal, cardiac, hepatic, or hematopoietic toxicity was observed. Other side effects, however, necessitated premature cessation of therapy in four patients. Overall, intravenously administered miconazole is an effective antifungal agent for these cutaneous infections.

Adolescent↗
PubMed1979

Chondrodermatitis nodularis chronica helicis. A review with emphasis on steroid therapy.

Chondrodermatitis nodularis chronica helicis, a disease involving the ear helix of middle-aged to elderly persons is described herein. The clinical, histologic, and therapeutic aspects of this entity are discussed with special emphasis on treatment with intralesional steroids. Several etiologic and pathogenetic mechanisms are also mentioned.

Cartilage Diseases↗
PubMed1979

Cowden's disease.

Cowden's disease, a rare genodermatosis, is associated with characteristic cutaneous and oral lesions: papillomas, verrucous papules, and acral keratoses. Various internal anomalies involving the breast, thyroid, and gastrointestinal, reproductive, and skeletal systems are also seen in patients with this syndrome complex. Twelve of the thirty-two reported patients have been subject to cancers, most commonly of the breast. The characteristic skin and oral lesions make possible an early diagnosis of this disease and permit close follow-up of these patients for the development of any internal disease.

Adult↗
PubMed1978

Bowenoid papulosis of the penis.

During the past 18 months we have studied 36 biopsy specimens taken from 11 young men ranging in age from 21 to 36, each of whom had multiple, reddish to violaceous papules, some distinctly verrucoid or velvety on either or both the shaft and glans of the penis. The clinical diagnoses accompanying the biopsy specimens were lichen planus, psoriasis and condyloma acuminatum. In no instance was carcinomia in situ suggested in the differential diagnosis. Histologically, however, all specimens submitted showed indubitable changes of squamous cell carcinoma in situ.

Adult↗
PubMed1978

Cowden's disease: a case report and review of the literature.

Cowden's disease is one of the rare genodermatoses. The most characteristic findings in this disease are cutaneous and oral lesions that are widespread papillomas and verrucous papules. On the palms the lesions are keratoses. Aside from these findings, this syndrome complex is sooner or later associated with various internal abnormalities involving the mammary, thyroid, gastrointestinal, reproductive and skeletal systems. In the 28 reported cases, 13 cancers have been found, most of the breasts. Because of the characteristic cutaneous and oral lesions, it is possible to recognize this disease early and then to follow afflicted patients closely for the possibility of development of cancers or other abnormalities of other organs.

Adult↗
PubMed1978

Skin changes and diseases associated with pregnancy.

During the gestational period, the skin is among the many organs undergoing changes. Various endocrine changes occurring in pregnancy are thought to give rise to certain skin changes such as pigmentary alterations, abnormalities in hair growth, vascular anomalies, and striae. Also, there are several skin diseases unique to the pregnant woman. Whereas the physiologic skin changes are mainly of cosmetic importance, the various pregnancy-unique skin diseases have associated symptoms, and an increase in both fetal and/or maternal morbidity and mortality is associated with several of these skin diseases.

Dermatitis↗