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Biomedical subjects

T R Todd

Publications and source records attributed to T R Todd.

77 records · Page 5Linked to original sources
PubMed1979

Selective superior mesenteric embolization for small intestinal hemorrhage.

A 25-year-old white woman who had previously undergone two operations for peptic ulcer disease, and was addicted to drugs and alcohol, had massive hemorrhage from the small intestine. Angiography pinpointed the jejunum as the source of bleeding. Because the patient had a coagulopathy she was considered a poor risk for surgery. Bleeding was controlled by embolization with sterile, commercially available Gelfoam (Upjohn) which was injected into the offending branch of the superior mesenteric artery. This is believed to be only the third documented case of embolization of small intestinal vessels. A review of the available literature is presented and the value of Gelfoam embolization as an adjunct in the control of hemorrhage in selected patients is stressed.

Adult↗
PubMed1978

Pulmonary capillary and permeability during hemorrhagic shock.

In previous experiments from this laboratory horseradish peroxidase was used to study the structural and functional characteristics of the normal canine pulmonary capillary membrane. The present study used the same technique to try to determine if any change occurred in the pulmonary capillary as a result of hemorrhagic shock. We found that hemorrhagic shock caused a fall (5 expt) or no change (2 expt) in estimated pulmonary transcapillary pressure based on Starling's equation. However, lymphatic flow from the lungs increased. Estimated of filtration coefficients showed a highly significant increase (P less than 0.01) during the hypotensive period. Pulmonary lymphatic protein concentrations were not altered, indicating that water and protein continued to traverse the membrane in the same proportions as under normotensive conditions. These data are consistent with recent observations of minimal changes in the intercellular junctions of the capillary endothelium following hemorrhagic shock made independently on lung tissue from these experiments.

Animals↗
PubMed1978

Pulmonary arterial wedge pressure in hemorrhagic shock.

To test the hypothesis that the position of a pulmonary arterial wedge catheter might affect its ability to measure left atrial pressure, we inserted 2 wedge catheters, one superiorly, and one dependently, in supine dogs. The position of the catheter tips and the zero level of the transducers were located on a lateral chest radiograph so that by referencing the transducers to the posterior surface of the lung and measuring the height of the catheter tip above that reference point, the zones in which the catheter tips were located were determined. When both catheters were in Zone III (pulmonary arterial pressure greater than left atrial pressure greater than alveolar pressure), the wedge pressures accurately reflected left atrial pressure. However, during hemorrhage, left atrial pressure decreased, and when the pulmonary arterial wedge catheter placed superiorly came under Zone II conditions (pulmonary arterial pressure greater than alveolar pressure greater than left atrial pressure), it recorded a constant pressure somewhat greater than left atrial pressure; the pulmonary arterial wedge catheter placed dependently, which remained in Zone III, continued to reflect left atrial pressure. We conclude that a pulmonary arterial wedge catheter measures left atrial pressure only when it is located in Zone III.

Animals↗