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Biomedical subjects

T R Swift

Publications and source records attributed to T R Swift.

At least 55 records · Page 3Linked to original sources
PubMed1978

Prolonged neonatal myasthenia gravis: electrophysiological studies.

A female infant with neonatal myasthenia gravis remained weak for an excessively long period compared to the usual situation in this disease process. At 71 days of age, electrophysiological studies revealed evidence of a defect in neuromuscular transmission that improved with intravenous Tensilon therapy. Repeat study at 183 days of age was normal. This case represents an unusually long time for an affected infant to have neonatal myasthenia gravis. Electrophysiological studies are of value in the diagnosis and management of patients with neonatal myasthenia gravis.

Edrophonium↗
PubMed1978

Systemic lupus erythematosus, myasthenia gravis, and Ehlers-Danlos syndrome.

Clinical, electrophysiological, and laboratory data are reported on a 21-year-old black woman with systemic lupus erythematosus, myasthenia gravis, and Ehlers-Danlos syndrome. The first two diseases are related by similar pathogenetic mechanisms. To our knowledge, this is the first patient reported with this unusual combination of rare diseases.

Adult↗
PubMed1978

Tc-99m pyrophosphate muscle labeling in McArdle syndrome.

This paper reports the findings on two patients with McArdle syndrome (myophosphorylase deficiency) in whom conventional bone scans with Tc-99m pyrophosphate revealed intense muscle labeling following exercise tests. The temporal pattern observed was similar to that seen with other types of muscle damage. The prolonged cramps often occurring with this entity appears to produce muscle damage that is readily demonstrable using conventional bone-scanning techniques.

Adult↗
PubMed1976

Peripheral nerve involvement in Hunter syndrome (mucopolysaccharidosis II).

A 20-year-old man with confirmed Hunter syndrome had entrapments of median and ulnar nerves. Sural nerve biopsy specimen revealed clear, lamellated, and granular inclusions in Schwann cells, fibroblasts, and perineurial cells. The clear inclusions are believed to represent storage of mucopolysaccharide, and the zebra bodies, ganglioside. Focal alterations in myelin were found, associated with moderately dense granular inclusions. Following carpal tunnel release operations, the patient experienced dramatic releif of symptoms.

Adult↗
PubMed1976

Radioisotope scanning in inflammatory muscle disease.

Fourteen whole-body rectilinear bone scans using technetium 99m-polyphosphate were done in nine patients with well-documented inflammatory myopathy (either polymyositis or dermatomyositis). In all nine patients, the scans showed evidence of increased muscle labeling. Muscle uptake was markedly increased in one patient, moderately increased in two patients, and minimally increased in six patients. The degree of muscle labeling correlated with the severity of the muscle weakness at the time the scan was done. In four patients, who received high-dose corticosteroid treatment, muscle uptake was decreased following therapy. These findings suggest that radioisotope scanning may be useful in the diagnosis and management of patients with inflammatory muscle diseases.

Adrenal Cortex Hormones↗
PubMed1975

Neonatal dystrophia myotonica. Electrophysiologic studies.

The diagnosis of dystrophia myotonica was established in a boy 3 hours old, and confirmed by family study and electromyography (EMG) at 5 days. Clinical features included hypotonia, facial diparesis, "tented" upper lip, and arthrogryposis of both knees. Percussion myotonia was elicited. The EMG disclosed characteristic bursts of electrical activity that waxed and waned on muscle percussion or needle movement. The EMG may be valuable in supporting the diagnosis of dystrophia myotonica in neonates suspected of having the disease.

Abnormalities, Multiple↗
PubMed1975

Tick paralysis: electrophysiologic studies.

A patient with tick paralysis had motor and sensory nerve conduction studies before and after removal of an engorged tick. The amplitudes of muscle action potentials evoked by stimulation of motor nerves were reduced initially, returning to normal after the tick was removed. Distal motor and sensory latencies also shortened after removal, and conduction velocities were improved 6 months later. Direct stimulation of muscle produced a normal response, and tests of neuromuscular transmission were normal, including the response to edrophonium. These findings are compatible with experimental results showing effects of the toxin on motor nerve terminals as well as on large sensory and motor nerves.

Child, Preschool↗
PubMed1975

Increased 99mTc-polyphosphate muscle uptake in a patient with polymyositis: case report.

A patient with well-documented rheumatoid arthritis and polymyositis displayed abnormal muscle uptake of 99mTc-polyphosphate during routine bone scanning for occult malignancy. The regions of increased uptake corresponded to the areas of clinically active inflammatory muscle disease. On serial scans the degree of muscle labeling correlated well with both clinical and laboratory indices of disease activity.

Adult↗
PubMed1971

Neurofibromatosis and leprosy.

Two patients with neurofibromatosis and leprosy are reported. Both had active lepromatous leprosy and generalized neurofibromata. The bacilli appear in huge numbers within the cytoplasm of the cells making up the neurofibromata, which become distended and resemble lepra cells. Since these cells are believed to derive from Schwann cells, the findings in these patients support the idea that leprosy affects nerves initially by proliferating in Schwann cells and producing changes within them.

Adult↗
PubMedDate not supplied

Weakness from magnesium-containing cathartics: electrophysiologic studies.

The case history of a patient with severe muscular weakness resulting from magnesium intoxication following oral and rectal administration of magnesium citrate cathartics is reported. The findings of the electrophysiologic studies were characteristic of the neuromuscular blockade seen in this disorder, including marked reduction in evoked muscle action potential amplitude which progressively decline on nerve stimulation at low rates, and a striking degree of facilitation of evoked muscle action potential after exercise or on high-frequency stimulation. When the hypermagnesemia was corrected, strength returned to normal.

Action Potentials↗
PubMedDate not supplied

Isolated mechanical lesions of the sural nerve.

One case of compression neuropathy and one case of iatrogenic stretch injury to the sural nerve were demonstrated with electrophysiologic (EP) testing. Isolated mechanical injuries to the sural nerve may occur more frequently than is generally realized, and EP studies can greatly aid in the diagnosis of these injuries, thus avoiding the necessity for neuroradiologic investigations.

Female↗