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Biomedical subjects

T R Malloy

Publications and source records attributed to T R Malloy.

53 records · Page 3Linked to original sources
PubMed1980

Transpubic urethroplasty for prostatomembranous urethral disruption.

Transpubic urethroplasty was done in 15 patients with prostatomembranous urethral disruption secondary to pelvic trauma. Satisfactory results were obtained in 13 patients (87 per cent). One patient remains partially incontinent, while 1 has a significant recurrent stricture. The operative technique to prevent complications is emphasized.

Adolescent↗
PubMed1980

The effects of bethanechol chloride on urodynamic parameters in normal women and in women with significant residual urine volumes.

A 5 mg. subcutaneous dose of bethanechol chloride was given to 12 women with residual urine volumes equal to or greater than 20 per cent of bladder capacity but no evidence of neurologic disease, or anatomic or functional outlet obstruction and to 27 normal women wtih approximately the same mean age. The cystometric and some profilometric parameters did change, indicating that the drug was pharmacologically active. No improvement in voiding function was noted, as judged by residual urine volume and flow rate measurements. These results raise significant questions regarding the contemporary use of this drug, especially in the currently recommended oral dosages.

Bethanechol Compounds↗
PubMed1980

Staging pelvic lymphadenectomy for carcinoma of the prostate review of 91 cases.

Bilateral pelvic lymphadenectomy was done in 91 consecutive patients for the staging of carcinoma of the prostate. Of the 91 patients 47 additionally received placement of radioactive gold grains or iodine seeds into the prostate. The incidence of positive nodes was 53 per cent in patients with clinical stage A2 disease, 17 per cent in stage B1, 29 per cent in stage B2 and 56 per cent in stage C disease. Pedal lymphangiography was shown not to be a useful staging procedure. Excellent correlation exists between histologic grade and pathologic stage. The surgical technique and low complication rate are discussed.

Aged↗
PubMed1980

Failure of the bethanechol supersensitivity test to predict improved voiding after subcutaneous bethanechol administration.

Subcutaneous administration of 5 mg. bethanechol chloride did not change significantly either flow rates or percentage residual urine in 11 patients with a positive bethanechol supersensitivity test. Therefore, a positive response to this test cannot be used to predict improved voiding function after subcutaneous or oral administration of the drug. Studies that purport to show a long-term rather than a short-term facilitory effect of this agent on voiding must satisfy rigid criteria, which include totally excluding a change in any other factor affecting the lower urinary tract.

Bethanechol Compounds↗
PubMed1980

Comparison of the inflatable penile and the Small-Carrion prostheses in the surgical treatment of erectile impotence.

In 1974 a combined 3-hospital assessment was undertaken to evaluate the surgical treatment of erectile impotence. A comparison study on the inflatable penile and the rigid rod (Small-Carrion) prostheses was established. The inflatable penile prosthesis was implanted in 105 patients, while 45 men received the Small-Carrion prosthesis. A long-term success rate was achieved in 98 patients (93 per cent) who received the inflatable prosthesis. This prosthesis was removed in 7 cases because of infection, pain or inability to operate it. Functional success was achieved in 39 patients (88 per cent) with the Samll-Carrion prosthesis. This prosthesis was removed in 6 cases, mainly because of infection and erosion of the rods into the urethra or glans penis. A guide line to proper prosthetic selection is presented for various patient populations.

Adult↗
PubMed1980

Omental transposition as an aid in genitourinary reconstructive procedures.

Mobilization of an intact omental pedicle graft for supportive use has been carried out in a variety of genitourinary reconstructive procedures. Mobilzation is accomplished by detachment of the omentum from the transverse colon and by separation from the greater curvature of the stomach. The right gastroepiploic artery is generally preserved as the blood supply to the omental pedicle. Further pedicle lengthening can be achieved as necessary by selective division of the omentum, based on the arterial anatomy. The rich vascular and lymphatic supply of the omentum and its attendant potential to contribute to healing, even in the presence of infection, while maintaining its suppleness and allowing epithelization to occur over its surface, makes the omental pedicle graft an extremely useful adjunct in the following difficult situations: complicated vesicovaginal, prostatorectal, and rectovaginal fistulas; reconstruction of the bladder neck and bulbo-membranous urethral areas; extensive injury to the bladder; and a variety of renal and ureteral reconstructive procedures.

Female↗
PubMed1980

Repair of vesicovaginal fistula by a suprapubic transvesical approach.

Thirty-four vesicovaginal fistulas of various causes were repaired using a suprapubic, transvesical approach modified after the original technique of O'Connor. Only four failures resulted. Two of the failures were attributed to residual or recurrent carcinoma and two to poor tissue healing resulting from an inadequate delay between the initial surgical procedure and an attempt at reconstructive surgery. Surgical complications included three wound infections and one instance of severe gastrointestinal bleeding. Technical considerations thought to be important include excision of all diseased tissue in the bladder and vagina; complete separation of the bladder from the vagina with a margin of healthy tissue in all directions; careful, watertight closure of both bladder and vagina without tension; interposition of peritoneum or omentum between the closed bladder and vagina, and initial postoperative maintenance of an uninfected and dry suture line.

Evaluation Studies as Topic↗
PubMed1979

Further experience with the inflatable penile prosthesis.

Since 1974, 93 men with erectile impotence have been treated with surgical implantation of an inflatable penile prosthesis. Followup has been 6 months to 4 years. Long-term functional success was achieved in 87 patients (93%). Complications requiring 31 secondary operations occurred in 27 patients (29%).

Erectile Dysfunction↗
PubMed1979

The reproducibility and significance of carbon dioxide urethral profilometry.

Infusion urethral profilometry using carbon dioxide as a medium is an interesting study with a wide range of variability from day to day in a single individual, a fact that considerably reduces the value of a single measurement as a diagnostic tool. Presently, all forms of infusion profilometry must be considered to be interpretable only within the framework of the entire neurourologic evaluation. The study may be useful to make the clinician more secure about a particular diagnosis and as an objective measurement for medico-legal documentation. It also may be useful in predicting and objectively demonstrating treatment results if normal variability can be excluded. However, a high level of skepticism should be maintained regarding the value of the profile in those situations in which its interpretation does not correlate with the impression formed from the remainder of the neurourologic evaluation.

Adult↗
PubMed1977

Hydroxyurea in stage D carcinoma of prostate.

Thirty patients with histologically proved metastatic prostatic adenocarcinoma Stage D were treated with a single oral dose of 80 mg. per Kg. hydroxyurea every third day (based on ideal or actual weight, whichever is less) and 12 mg. chlorotrianisene per day. Toxicity was mild. The most common manifestations were nausea, occasional vomiting, and leukopenia. A definite attempt was made to depress the white blood count to approximately 2,000 cells per cu. mm. Hydroxyurea was not discontinued unless the white blood count decreased to less than 2,000 cells per cu. mm., after which a single dose was usually omitted. Omission of a single dose would allow the white blood count to return promptly to more than 2,000 cells per cu. mm. Objective tumor regression was demonstrated in 15 of the 30 patients, and most patients had a definite improvement in the quality of life.

Aged↗
PubMed1977

Management of simple ureterolithotomy closure.

Two methods of ureterotomy closure, loose adventitial closure and an unsutured incision, were evaluated and compared in 89 cases of simple ureterolithotomy. The loose adventitial closure was associated with a significantly shorter period of postoperative urinary drainage and a lower incidence of ureteral narrowing found at follow-up urographic examination.

Adolescent↗
PubMed1977

Surgical treatment of erectile impotence with inflatable penile prosthesis.

Thirty-nine men with erectile impotence were treated with surgical implantation of an inflatable penile prosthesis. The patients were followed for 6 months to 2 years. Thirty-five patients (90 per cent) have expressed long-term satisfaction with the appearance and performance of the prosthesis. Major complications developed in 9 patients (23 per cent), requiring 12 subsequent operative procedures.

Erectile Dysfunction↗