A predictive model for estimating rat oral LD50 values.
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Administration, Oral↗
Biomedical subjects
T R Lander
Publications and source records attributed to T R Lander.
Teratogenesis: a statistical structure-activity model.
This structure-activity model of teratogenicity was developed to provide the ability to rank untested compounds by their probability of teratogenicity. The model is based on 430 compounds collected from various sources in the literature and scored from zero to one as to evidence of teratogenicity. A discriminant equation then separates those compounds in the extremes of this distribution. The false positive classification rate based on the compounds in the equation is approximately 8% and the false negative rate approximately 10%. Approximately 22% of the compounds are not classifiable as either teratogens or nonteratogens with this equation.
Models, Biological↗
Mutagenicity (Ames): a structure-activity model.
A statistical structure-activity model of the Salmonella typhimurium (Ames) test has been devised based on 472 chemicals for which this endpoint has been measured. The model uses substructural fragments as the independent parameters to explain the difference in mutagenicity of the different chemicals. The model is able to classify 86% of the chemicals into their correct categories; the false-positive rate is 4.7%, and the false-negative rate 5.3%. Approximately 10% of the chemicals cannot be classified by the existing equation. This structure-activity model can be used as a preliminary screen prior to other testing as well as for setting priorities for more detailed investigations.
False Negative Reactions↗