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Biomedical subjects

T R Fraser

Publications and source records attributed to T R Fraser.

At least 91 records · Page 5Linked to original sources
PubMed1969

Serum growth hormone levels and size of pituitary tumour in untreated acromegaly.

Serum levels of growth hormone were measured in 84 untreated acromegalic patients. The range of mean level during a glucose tolerance test was 8 to 1,860 ng./ml. and was lognormally distributed. Mean level was reproducible and correlated moderately well with maximum sellar area on lateral tomography. The hormone level was more responsive to oral glucose and insulin-induced hypoglycaemia in patients with smaller tumours. Attention is drawn to limitations of plain radiographs in assessing the size of a pituitary tumour. Suprasellar tumour extensions may be present in patients without visual field defects.

Acromegaly↗
PubMed1969

Treatment of thyrotoxicosis with low doses of radioactive iodine.

In a series of 156 thyrotoxic patients treated with low doses of radioactive iodine the therapeutic dose was calculated by means of a sliding scale in which the dose level was varied according to the estimated size of the gland. Of the patients so treated 56.5% achieved a remission with a single dose of (131)I. The incidence of hypothyroidism at one year was 5%.

Carbimazole↗
PubMed1969

Serum growth hormone levels and the response of diabetic retinopathy to pituitary ablation.

Serum growth hormone levels were measured during insulin tolerance tests in 36 patients after yttrium-90 pituitary implantation for diabetic retinopathy. The response of the new blood vessels was more clearly related to loss of growth hormone function than was the improvement of retinal haemorrhages and microaneurysms. The overall response of the retinopathy was greatest when growth hormone function was lost.Since the loss of growth hormone function was related to the loss of other aspects of anterior pituitary function, a unique role of growth hormone in the response of diabetic retinopathy to pituitary ablation could not be established.

Diabetic Retinopathy↗