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Biomedical subjects

T R Fenton

Publications and source records attributed to T R Fenton.

29 records · Page 2Linked to original sources
PubMed1983

A pathophysiological study of the intestinal manifestations of a vasoactive intestinal peptide, calcitonin, and catecholamine-secreting tumour.

A three year old girl with severe watery diarrhoea and a vasoactive intestinal peptide, calcitonin, and catecholamine-secreting supra-renal ganglioneuroblastoma is reported. Steady-state perfusion studies showed the jejunum to be in a net secretory state with respect to water, sodium, and chloride at low concentrations (2 mmol/l) of glucose whereas higher concentrations (56 mmol/l) reversed secretion to absorption; transmural rectal potential difference was increased (lumen negative); Na+ absorption by the rectum was impaired and secretion of potassium and bicarbonate excessive. Motility studies showed prolonged, slowly propagated migrating motor complexes with abnormal runs of non-propagated contractions in the fasting state. During perfusion with glucose, no postprandial activity occurred. These results suggest that diarrhoea results from small intestinal secretion with impaired colonic function and that tumour products may have a direct effect on intestinal motility.

Adrenal Gland Neoplasms↗
PubMed1981

Proctoscopy in infancy with reference to its use in necrotising enterocolitis.

Experience with the fairly simple and safe technique of proctoscopy in an infant using an ordinary auroscope is reported. The use of the auroscope showed the presence of a frank colitis in 13 of 14 consecutive cases of necrotising enterocolitis. A prospective study was made during a 6-month period of 51 infants with diarrhoea referred to a gastroenterology isolation unit; proctoscopic findings that suggested colitis were found in 10. Of these, 3 appeared to have necrotising enterocolitis; 3 had salmonella or shigella dysentery; in 3 of the remaining 4 the findings were localised to the anus, with normal mucosa above. This was attributed to a mild rectal prolapse on straining. There was no correlation between the severity of the diarrhoea and the presence of colitis. Proctoscopy is safe and valuable in the early diagnosis of necrotising enterocolitis. It is also helped in assessing the progress of the disease.

Acute Disease↗
PubMed1978

Transmural myocardial deformation in the canine left ventricular wall.

A biplane cineradiographic technique was used to measure deformation of the myocardium as indicated by small lead spheres implanted into the anterior left ventricular wall of anesthetized dogs. Deformation was resolved into nine separate components for each of the epicardial, middle, and endocardial layers. The data illustrate the mechanical effect of myocardial fiber orientation and the ability of muscle layers to deform differentially. In order to present an overview of all the results, the implications of the deformation components are discussed first separately and then in a coordinated fashion.

Animals↗
PubMedDate not supplied

Twin pregnancy: the distribution of maternal weight gain of non-smoking normal weight women.

We documented the pattern and distribution of weight gain through twin pregnancies of healthy non-smoking women with good birth outcomes. The mean birthweight was 2621 g and the mean gestational age at delivery was 37.6 weeks. As few of the women were weighed after 34 weeks, the weight gain graph was drawn to this point. The sample was separated into subgroups based on birthweights and gender of the infants. Weight gains, parity, income, first measured weight, BMI and Apgars were not different between the subgroups. The only difference between those with infants that were small for gestational age (SGA), over 3 kg, or intermediate in weight was gestational age. For the groups divided by infant gender, the only differences were maternal age and infant birthweight. The mean, median and 80% confidence limits for weight gain at 34 weeks were 14.1, 13.6, and between 8.5 and 19.4 kg, respectively. There was a wide range of weight gained by these women carrying twin pregnancies.

Adult↗