Biomedical subjects
Publications and source records attributed to T R Caraccio.
This is the fourth reported case of acute pancreatitis associated with acetaminophen overdose. The patient had ingested the smallest amount of acetaminophen (9.75-13 g) that has been reported to produce acute pancreatitis. This patient also suffered liver and renal impairment and developed an ileus and ascites. Despite late therapy and laboratory tests that indicated a poor prognosis the patient made a complete recovery without sequelae.
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This article discusses the management of antidysrhythmic drug overdoses in children and adolescents.
The status of syrup of ipecac as a nonprescription drug has helped reduce the death rate in children, ages 1 to 5 years. The drug has proven safe and effective in children in the recommended doses. To deprive parents of ready access to ipecac syrup would result in increased disability and death from poisoning and more emergency department visits.
This article reports five patients who had taken a substantial medication overdose and presented in coma. Two had taken a salicylate overdose and three a phenobarbital overdose (one of these ingested a combination of phenobarbital and phenytoin). The cases were treated by our standard protocol of supportive therapy and alkaline diuresis plus repetitive oral doses of activated charcoal (gastrointestinal dialysis). All patients were alert and oriented within 24 hours. Toxicokinetic analysis of the blood levels is discussed. Gastrointestinal dialysis represents a relatively noninvasive method that may benefit certain intoxicated patients even after systemic absorption has occurred. The technique and recommendations for its use are discussed and described in detail.
The authors have compiled a list of common household products and drugs that are frequently ingested by children and may be considered nontoxic unless taken deliberately or in large amounts. An understanding of the nontoxic ingestion should prevent overtreatment and decrease emergency room visits.
We have compiled a list of common household products and drugs that are frequently ingested by children and may be considered nontoxic unless taken deliberately or in large amounts. An understanding of the nontoxic ingestion should prevent overtreatment, decrease emergency room visits, and allow physicians and poison control centers the opportunity to practice poison prevention. The reporting of all ingestions is encouraged to obtain information on the human experiment that occurs when a non-edible material is ingested. Only as we accumulate this knowledge will we be able to advise with a degree of certainty what treatment is needed.
Management of ingestions of small flat disc batteries has been controversial. The Nassau County Medical Center's Long Island Regional Poison Control Center has had 30 calls concerning battery ingestions in the past 16 months. In 1976, the National Clearinghouse for Poison Control Centers reported 42 battery ingestions for the entire nation. Only one of our cases required surgery because the battery remained in the cecum for five days. The battery was removed intact. Management guidelines for ingestions of batteries containing alkali or toxic metals are suggested.