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Biomedical subjects

T Q Nguyen

Publications and source records attributed to T Q Nguyen.

33 records · Page 2Linked to original sources
PubMed1995

The safety of orotracheal intubation in patients with unstable cervical spine fracture or high spinal cord injury.

BACKGROUND: The potential merits and dangers of orotracheal and nasotracheal intubation in patients with injury to the cervical spine or spinal cord continue to be debated. To address this issue, a prospective study was conducted at a level 1 trauma center in patients with respiratory embarrassment and either or both of these injuries. MATERIALS AND METHODS: Over a 7-year period, all such patients underwent neurologic examination by a trauma surgeon on arrival at the trauma center, immediately after endotracheal intubation, and at frequent intervals throughout hospitalization. Cervical immobilization was maintained manually during endotracheal intubation. When necessary, patients were sedated or paralyzed with short-acting pharmacologic agents. RESULTS: During the study period, there were 81 patients with 98 cervical vertebral body fractures, but without evidence of spinal cord injury on initial examination. Sixty-seven patients (83%) were legally intoxicated, and 12 patients had closed head injury. Endotracheal intubation was performed in 26 patients with unstable fractures, and 22 patients were intubated via the oral route. No patient manifested a subsequent neurologic deficit. Sixty-nine additional patients presented with high spinal cord injury; 16 had no cervical spine fracture, and 53 patients had 61 fractures of the cervical vertebrae. Sixty patients (87%) were intoxicated, and 8 patients had closed head injury. Endotracheal intubation was performed in 29 of these patients, and 26 patients were intubated via the oral route. No patient experienced further neurologic deficit following endotracheal intubation. CONCLUSION: In trauma victims with or at high risk of cervical spinal cord injury, orotracheal intubation is a rapid, safe means of achieving airway control.

Adult↗
PubMed1993

1;19 translocation in human meningioma.

BACKGROUND: Loss of chromosome 22 represents the most common chromosome abnormality (70%) in meningiomas. The remainder (30%) have a normal karyotype. Not only are the structural changes rare, they also occur simultaneously with various chromosome losses. METHODS: The authors identified and studied the meningiomas of two patients with standard tumor cell culture technique and chromosome preparation. RESULTS: Twenty karyotypes from each meningioma had a 46 modal chromosome number with t(1;19) (q21;p13) in all cells. CONCLUSIONS: The sole change of the (1;19) translocation in meningioma, without any other changes such as chromosome loss, as shown in this study, is unique and has never been reported before in the literature, to the knowledge of the authors. Additional study is needed to learn more about the rate of occurrence and the significant impact on meningeal tumor genesis.

Chromosomes, Human, Pair 1↗
PubMed1986

Pneumocephalus secondary to tension pneumothorax associated with comminuted fracture of the thoracic spine.

We present an unusual case of pneumocephalus secondary to a tension pneumothorax associated with fracture of the thoracic spine. Air from a pneumothorax entered the thoracic intraspinal compartment and the intracranial cavity through a comminuted fracture of the spine. The pneumocephalus and the pneumothorax resolved after aspiration of the intrathoracic air via an intercostal catheter. Diagnosis, therapeutic modalities, and potential complications of a pneumocephalus and of a communication between the thoracic cavity and the spinal dural space are discussed.

Adult↗
PubMed1984

Therapeutic benefits of combination chemotherapy with vincristine, BCNU, and procarbazine on recurrent cystic craniopharyngioma. A case report.

The authors report a case of recurrent cystic craniopharyngioma managed with chemotherapy. The patient refused adamantly the alternative therapy methods, such as surgery and radiotherapy, initially offered. Eight courses of chemotherapy with vincristine (2 mg/M2, i.v.) on day 1,1,3-bis(2-chloroethyl)-1-nitrosourea (100 mg/M2, i.v.) on day 2, and procarbazine (50 mg, b.i.d., p.o.) on days 3 to 21 were administered at 6 week intervals. The effectiveness of this treatment modality has been evaluated by the unequivocal neurological improvement and by the decreases in size of the cyst using serial computerized tomography. Toxocities were mild and chiefly hematological.

Adult↗
PubMed1984

Complications associated with intra-arterial BCNU administered in combination with vincristine and procarbazine for the treatment of malignant brain tumors.

We have used intra-arterial (i.a.) 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) either alone or as part of adjuvant chemotherapy in patients with malignant brain tumors over a 3 year period (1979-1982). The i.a. BCNU technique was used 111 times to infuse 134 arteries in 37 patients. These patients, 28 cases with glial tumor and 9 cases with brain metastasis, received i.a. BCNU in combination with Vincristine and Procarbazine every 6 weeks. Complications encountered were transient and included: periorbital erythralgia or occipital-nuchal pain in 23 (62%), mild confusion and disorientation in 14 (38%), and ipsilateral conjunctival edema in 10 (27%). Reversible myelosuppression was not found. Our findings suggest that BCNU (100 mg/M2) may be given by i.a. infusion in combination chemotherapy without persistent severe untoward effects with a cumulative dose of 700 mg/M2.

Adolescent↗
PubMed1983

Internal metal plate fixation combined with anterior interbody fusion in cases of cervical spine injury.

The authors report their experience with the use of a modified method of internal metal plate fixation combined with anterior interbody fusion in six patients with an unstable lower cervical spine. All of the patients had sustained severe cervical spine injuries in accidents. In most of the cases, the operation was carried out at 1 to 4 weeks after injury. The insertion of the metal plate was very simple and maintained the block bone graft in satisfactory position. This alternative method of internal fixation of the cervical spine was not associated with morbidity, allowed very early mobilization, and shortened the hospital stay.

Adolescent↗
PubMed1983

Autogeneic fat transplants in the epidural space in routine lumbar spine surgery.

This report presents our experience with the use of autogeneic fat patch grafts to protect the exposed dura mater during lumbar spine operations. A total of 44 consecutive surgical procedures was performed primarily for discogenic or spondylotic disease from 1979 to 1982. Prophylactic antibiotics were used in 21 (48%) cases. The autogeneic fat transplants were well accepted by all recipients during 10.4 (1 to 32) months of follow-up. Fat grafts, greater than 1 cm in thickness, were easily identified on subsequent computed tomographic (CT) scans. There were no postoperative wound infections. However, 1 patient developed a large subcutaneous sterile fluid accumulation at the fat donor site, which required surgical intervention. Our results, both short and long term, indicate that autogeneic fat transplants may be well tolerated in the lumbar spine area. The fat graft viability as demonstrated by CT scanning and histological examination supports the contention that autogeneic fat interposed between dura mater and overlying musculature may serve as a barrier limiting the growth of cicatrix into the spinal canal.

Adipose Tissue↗
PubMed1983

An unusual late complication of acrylic spinal fusion: case report.

The authors report an unusual complication after posterior cervical spine fusion utilizing methyl methacrylate and metallic pins. Eight months postoperatively, the patient noticed a subcutaneous foreign body in the right side of the neck. Radiographic and operative findings confirmed the clinical impression of migration of one of the metallic pins.

Aged↗
PubMedDate not supplied

Antibody response after treatment in cattle infected with Psoroptes ovis.

The decline of anti-Psoroptes ovis antibody titres after treatment was studied in six groups of naturally infected cattle. In all trials, using a limiting dilution technique, the specific antibody levels were assessed by ELISA on sera collected at regular intervals up to 78 days post treatment. All individual antibody titres started to decline between day 7 and day 14 post treatment. A linear decrease was observed. In a limited trial, five experimentally infected animals were bled monthly after treatment and seronegativity was reached within four months. The results obtained were in agreement with those obtained in the five field trials. Using a linear regression model, it was estimated by interpolation that most of the animals would have been seronegative within seven months post treatment. These results suggest that the exposure to specific P ovis antigen stops with the end of parasite activity and that dead mites are relatively non-immunogenic.

Animals↗
PubMedDate not supplied

[Evaluation of malaria vector control measures in central Vietnam (1976-1991)].

Activities used to control malaria transmission in the pilot station of Vanh Canh in the Binh Dinh Province of central Vietnam from 1976 to 1991 have been evaluated. These activities were: spraying DDT in and around the houses in the villages and the settlements in the fields; spraying lambdacyalothrin in the houses; and use of bed-nets impregnated with permethrin. Their efficacy was measured by the number of fever episodes due to malaria infections among the population. The spraying of DDT in the houses was followed by a reduction of malaria infection by more than 90%. However, spraying of the settlements was not advantageous. The termination of DDT spraying was not followed by an increase of malaria infections. Spraying with lambdacyalothrin was slightly more effective than with pyrimiphos and DDT. The use of pesticide-impregnated bed-nets was efficient, especially in the villages far away from the forest. Thus, these activities can contribute to the control of the malaria endemic in central Vietnam.

Adolescent↗