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Biomedical subjects

T Poole

Publications and source records attributed to T Poole.

14 recordsLinked to original sources
PubMed1997

Happy animals make good science.

In this paper the question is posed whether it is not only better for the animal to be happy, but whether its state of mind may also have the potential to influence the scientific results derived from it. To ensure good science, the animal should have a normal physiology and behaviour, apart from specific adverse effects under investigation. There is a growing body of evidence from a wide variety of sources to show that animals whose well-being is compromised are often physiologically and immunologically abnormal and that experiments using them may reach unreliable conclusions. On scientific, as well as ethical grounds, therefore, the psychological well-being of laboratory animals should be an important concern for veterinarians, animal technicians and scientists.

Animal Husbandry↗
PubMed1996

Increasing OR efficiency with a specialty services manual.

The successful operation of a modern ophthalmology OR is dependent on a knowledgeable, well-educated nursing staff. To improve communication and teamwork between ophthalmology surgeons and nursing staff members at the Louisiana State University Medical Center University Hospital, Shreveport, we developed an OR manual. We reduced our level of frustration by producing a manual that facilitates the day-to-day operation of the surgical services department. The manual provides consistent information for our ophthalmic surgical procedures; functions as a reference source; and promotes an efficient, productive OR. Although we designed this manual for the ophthalmology surgical service at our medical center, its structure can be applied to other surgical specialties.

Efficiency, Organizational↗
PubMed1996

Early use of the Gore-Tex Stretch Graft.

This study reports firstly the overall outcome with the 4-7 mm tapered Gore-Tex Stretch Vascular Graft and secondly the feasibility of early (< 14 days) cannulation hemodialysis in 270 consecutive patients for first-time forearm loop placement. Ninety-six (36%) cases were cannulated within 14 days and 78 cases within 7 days. The overall results with the stretch graft are excellent. The statistically significantly worse outcome with early cannulation was mainly due to a select patient population (as determined by proportional hazards regression analysis) being more acutely ill, urgently needing hemodialysis and having no other options for needle puncture. A prospective randomized study, however, is warranted to fully resolve the safety issue of early cannulation.

Adolescent↗
PubMed1994

Characterization of skin-infiltrating cells during acute graft-versus-host disease following bone marrow transplantation using unrelated marrow donors.

To characterize skin-infiltrating T lymphocytes during acute GVHD, skin biopsies were obtained from two patients who received unrelated marrow matched for HLA-A, -B, -DR, and -DQ but mismatched for -DP. A total of 120 T-cell clones were generated. Phenotype analysis of the clones showed that the majority of cells were CD4+ and expressed alpha/beta TCR. HLA-DP oligonucleotide genotyping of the clones revealed the presence of lymphoid chimerism. PLT assay showed the lack of HLA specificity, including mismatched HLA-DP. However, mAb to HLA antigens blocked proliferation of the majority of the clones, indicating that the clones recognized HLA-associated molecules. Interestingly, proliferation of two CD4+ T-cell clones was inhibited by class I mAb. A few of the clones revealed augmented proliferation in the presence of CMV antigens and a few revealed cytolytic activity. The above study suggests that (a) CD4+ helper T cells may be primarily responsible for immunopathogenesis of skin manifestations during acute GVHD, (b) there is a mixed lymphoid chimerism in skin during acute GVHD, (c) HLA-DP may not be a factor contributing to the development of acute GVHD, (d) the peptide of the HLA groove or superantigen associated with HLA molecules may be the stimulatory antigen, and (e) CMV antigens appear to stimulate some of the skin-infiltrating T lymphocytes.

Base Sequence↗
PubMed1991

A five-year analysis of botulinum toxin type A injections: some unusual features.

We analyzed patients treated during the past five years with botulinum toxin type A for strabismus and blepharospasm, reviewed our successes, failures, and unusual cases, and drew conclusions based on these treatments. Thirty-seven percent of the strabismus patients were cured, but many patients who were outside the strict definitions, still believed that they were significantly improved. A prominent feature in the treatment of strabismus was variability. Frequently, patients expected to do poorly had encouraging results. One permanent overcorrection occurred, and it converted an esotopic patient into an exotropic one with diplopia. This has persisted for 2.5 years and is the longest reported overcorrection to our knowledge. Our results indicate that larger doses of botulinum toxin produce longer spasm-free intervals in the treatment of blepharospasm. One patient receiving injections for her blepharospasm discovered that its cause was her sedative medication. This is the first reported case of a benzodiazepine inducing blepharospasm to our knowledge.

Benzodiazepines↗
PubMed1989

Randomised double blind controlled trial of cyclosporin in multiple sclerosis.

In a 2 year double blind controlled trial of cyclosporin against placebo in multiple sclerosis conducted at two centres there was a beneficial effect of the therapy upon the progression of the disease, relapse rate and relapse severity at one of the centres where the patients received a mean dose of 7.2 mg/kg/day. This beneficial effect was not seen in the other centre where a lower dose (mean 5 mg/kg/day) was given. Reduction in clinical progression was accompanied by decreased IgG synthesis in the central nervous system. Side effects included hypertension, renal insufficiency and anaemia and were of such severity to preclude the use of cyclosporin in a high enough dose to alter the course of the disease.

Adolescent↗
PubMed1988

Cricoid pressure and the pressor response to tracheal intubation.

Forty healthy adults who underwent rapid sequence induction of anaesthesia were allocated randomly to receive either cricoid pressure or its stimulation. The anticipated increase in systolic arterial pressure and heart rate after laryngoscopy and tracheal intubation were not altered significantly by the application of cricoid pressure.

Adult↗
PubMed1983

Relationship of duration of analgesia to opioid pharmacokinetic variables.

That physiological effects are directly related to concentration at the site of action has been validated for only a few classes of drugs. For opiates, a direct correlation is known to exist between concentration and magnitude of analgesia, but has not been shown for duration of analgesia. These experiments in rats, using opiates whose elimination half-lives differ by a factor of 2 1/2, in a range of doses that produce 10-90% of maximal analgesic effect, show that duration is not dependent on dose or rate of elimination of opiate analgesics. The data suggest that analgesic duration is not determined by the pharmacokinetics of opiates at the receptors where these drugs act to elicit analgesia.

Animals↗
PubMed1976

The measurement of urethral resistance and mural tension using simple programmable modules.

The theory of urethral resistance and the derivation or mural tension have been discussed. A method for the continuous calculation and presentation of these parameters has been described. Urethral resistance and mural tensions are altered by the presence of bladder outflow obstruction and have been shown to return to normality after the obstruction is removed.

Humans↗