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T Ponchon

Publications and source records attributed to T Ponchon.

At least 37 records · Page 2Linked to original sources
PubMed2003

Diagnosis and treatment of biliary obstruction caused by portal cavernoma.

While hemorrhagic complications of portal cavernoma are frequent, compression of the bile ducts by portal cavernoma is uncommon and treatment is still a matter for debate. We report here six new cases in order to describe: (a) the clinical, biological, and morphological features of this condition, and (b) the long-term results of a combined endoscopic and surgical treatment. The median age of patients at the time of diagnosis was 36.5 years. The circumstances of diagnosis were acute cholangitis (n=3), asymptomatic biological cholestasis (n=1), pruritus, jaundice and asthenia (n=1) and jaundice alone (n=1). Portal cavernoma and bile duct dilatation were confirmed by abdominal ultrasonography with pulsed color doppler and endoscopic retrograde cholangiography (ERC). Gallstones were found in four patients. Following stenting of the bile duct, there was a good outcome in two patients. In four patients, after failure of prolonged endoscopic treatment, second-line surgical portal-systemic shunting allowed removal of the biliary stent, and no recurrence of disease. In conclusion, biliary involvement in portal cavernoma is now a well-recognized entity, and our results suggest that combined endoscopic and surgical treatment could be required.

Adult↗
PubMed2003

Diagnostic value of endoscopic capsule in patients with obscure digestive bleeding: blinded comparison with video push-enteroscopy.

BACKGROUND AND STUDY AIMS: This study was designed to prospectively compare the diagnostic yield of the M2A endoscopic capsule with that of video push-enteroscopy in exploring the small intestine in patients with obscure digestive bleeding. PATIENTS AND METHODS: Patients with either occult or overt obscure digestive bleeding and a negative endoscopic work-up underwent a double intestinal investigation, with video push-enteroscopy and a wireless capsule, performed blindly by separate examiners. The diagnostic yield for each technique was defined as the frequency of detection of clinically relevant intestinal lesions, i. e. those having the potential for bleeding. RESULTS: 60 patients (27 men, 33 women; age 58 +/- 18 years; hemoglobin 9.4 +/- 2.5 g/dl) were included, 32 with occult and 28 with overt bleeding. Results were analyzed for 58 patients, who completed both examinations. Lesions were detected in 43 patients: with both techniques in 19, only by capsule in 21, and, conversely, only by push-enteroscopy in 3 ( P = 0.04). Final diagnoses were as follows: a P2 lesion with high bleeding potential in 28 patients (19 angiomata, 6 ulcerations, 2 tumors, 1 case of intestinal varices); a P1 lesion with intermediate bleeding potential in 15 patients (2 patients with mucosal erosions, 13 patients with mucosal red spots); and there were normal findings from 15 procedures. No procedure induced any complication. CONCLUSION: The use of the wireless endoscopy capsule detects significantly more clinically relevant intestinal lesions than video push-enteroscopy in patients with obscure digestive bleeding, raising the diagnostic yield to 67.2 %. Its influence on the clinical outcome for patients needs further investigation.

Adult↗
PubMed2003

Tolerance and efficacy of argon plasma coagulation for controlling bleeding in patients with typical and atypical manifestations of watermelon stomach.

BACKGROUND AND STUDY AIMS: Watermelon stomach is a well-known cause of gastrointestinal bleeding and anemia. This study investigated the efficacy of and patient tolerance for argon plasma coagulation (APC) in this condition. PATIENTS AND METHODS: The reports of 21 patients with watermelon stomach who were treated using APC from February 1998 to August 2001 were reviewed. The efficacy of APC was evaluated on the basis of the patients' symptoms, transfusion requirements, and hemoglobin levels. RESULTS: Fifty-nine APC sessions were carried out (mean 2.81 sessions per patient, range one to five). Depending on the bleeding outcome and lesion intensity, repeat treatments were carried out with a mean delay of 1.8 months (range 2 days - 6 months). The mean follow-up period after the last session was 14.9 months (1 - 60.6 months). All of the patients required repeated blood transfusions before APC, compared with only two patients after treatment. One of these two patients died of uncontrolled bleeding despite APC. The mean hemoglobin level was 80.9 g/l before treatment, compared with 103.2 g/l after treatment. Three patients had recurrent bleeding 4.4 - 31.7 months (mean 13.8 months) after the last session and required a further session of APC, which controlled bleeding in all cases. Complications encountered consisted of two cases of hematemesis and one of sepsis. CONCLUSIONS: APC was effective in controlling bleeding due to watermelon stomach in the great majority of patients, with a low complication rate.

Aged↗
PubMed2002

Diagnostic ERCP.

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Biliary Tract Diseases↗
PubMed2001

Endoscopic mucosal resection.

Endoscopic mucosal resection (EMR), or mucosectomy technique, developed by Japanese endoscopists consists of resecting flat and polypoid neoplasms of the mucosa by longitudinal section through the submucosa. This technique is relatively simple and carries a low morbidity. It represents an important advance for endoscopists in both technical and cancer areas. Compared with the endoscopic methods of tumor destruction (laser, plasma coagulation), EMR presents the advantage of obtaining a complete specimen for histologic analysis.

Carcinoma, Squamous Cell↗
PubMed2001

(13)CO(2) breath tests: comparison of isotope ratio mass spectrometry and non-dispersive infrared spectrometry results.

BACKGROUND AND AIMS: Isotope ratio mass spectrometry is the standard analytical method for (13)CO(2) breath tests. The goal of this study was to compare the results of (13)CO(2) breath tests obtained by non dispersive infrared spectrometry, a new, simpler and cheaper method, with those obtained by the gold standard method. METHODS: Three hundred and eight patients were included: 150 underwent a urea breath test for Helicobacter pylori diagnosis, 140 an aminopyrine breath test to measure liver function, and 18 an octanoic acid breath test for gastric emptying evaluation. A total of 750 breath samples were obtained in duplicate for isotope ratio mass and infrared spectrometry analyses. Breath test results were compared using Bland-Altman plots. RESULTS: The agreement between the two methods was excellent for urea breath tests (kappa coefficient=0.96), with only 3 discordant results. Although (13)C isotopic enrichment in breath was significantly lower with infrared spectrometry (P<0.0001), the agreement for the results of aminopyrine and octanoic acid breath tests was excellent. The clinical significance of these tests was similar for both methods. CONCLUSIONS: Infrared spectrometry results are comparable to isotope ratio mass spectrometry. Because this analytical method is simpler and less expensive, it could be used for clinical applications of (13)CO(2) breath tests.

Adolescent↗
PubMed2000

Diagnostic endoscopic retrograde cholangiopancreatography.

The importance of diagnostic endoscopic retrograde cholangiography (ERCP) has dramatically decreased owing to the development of less invasive techniques such as ultrasonography, computed tomography, endoscopic ultrasonography, and finally magnetic resonance cholangiopancreatography (MRCP). MRCP is becoming the gold standard in the diagnostic work-up of the pancreaticobiliary duct. However, MRCP cannot solve all the problems that occur, and still has inadequate resolution for small stones and tiny pancreatic and bile duct lesions. ERCP continues to be useful in difficult cases and when the diagnosis is uncertain, particularly when fluid collection and tissue sampling are necessary. However, several alternatives to sphincter of Oddi manometry have been proposed. Finally, ERCP is always the first step before endoscopic treatment, which in contrast to diagnostic ERCP is still widely used.

Animals↗