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T Pap

Publications and source records attributed to T Pap.

49 records · Page 3Linked to original sources
PubMed1991

Blood vessels in human immunodeficiency virus-related lymphoadenopathy: high endothelial venules and lymphocyte migration.

The vasculature of 25 lymph nodes of patients with human immunodeficiency virus-related lymphadenopathy was investigated morphometrically. The number of small vessels, the morphological features of high endothelial venules and the migratory index of the lymphocytes passing through the high endothelial venules, as well as the stage-dependent change of each parameter, were analysed. Twenty reactive lymph nodes served as controls. The total number of vessels in the HIV-infected lymph nodes was relatively stable. However, the small vessels with flat endothelium increased in number, while the number of high endothelial venules decreased as the disorder progressed, and the decrease in the lymphocyte migration seemed to precede the change in the morphology of high endothelial venules. The presumptive role of these alterations in the pathogenesis of the investigated disorder is emphasized.

AIDS-Related Complex↗
PubMed1991

Antigen-induced changes in the lymphocyte-high endothelial venule interaction.

The sequential changes of some morphometric parameters (lymph node weight, high endothelial venule (HEV)-content) after an antigenic challenge (sheep red blood cell; SRBC) and the alterations of HEV-function (HEV-adhesiveness measured with a HEV binding assay) were studied in rat lymph nodes over a period of seven days with daily measurements. Authors suggest that the proper estimation of the HEV-content of a lymph node in a HEV binding assay allows to express the HEV-adhesiveness numerically, and to compare the data obtained by this assay quantitatively. The HEV-adhesiveness is the strongest on day 6 after the antigenic challenge, the early increase in weight on day 2 is attributed to an increased blood flow and the changes in the HEV-content are presumed to reflect a simple dilation of HEVs (on day 2) and later (on days 4 and 5) an increase in the height of high endothelial (HE) cells. A crucial role is ascribed to the altered HEV-adhesiveness in the increase of lymphocyte migration to the challenged lymph nodes.

Animals↗
PubMed1991

Antigen-induced changes in the lymphocyte-high endothelial venule interaction.

The sequentional changes of some morphometric parameters (lymph node weight, high endothelial venule (HEV)-content) after an antigenic challenge (sheep red blood cell; SRBC) and the alterations of HEV-function (HEV-adhesiveness measured with a HEV binding assay) were studied in rat lymph nodes over a period of seven days with daily measurements. Authors suggest that the proper estimation of the HEV-content of a lymph node in a HEV binding assay allows to express the HEV-adhesiveness numerically, and to compare the data obtained by this assay quantitatively. The HEV-adhesiveness is the strongest on day 6 after the antigenic challenge, the early increase in weight on day 2 is attributed to an increased blood flow and the changes in the HEV-content are presumed to reflect a simple dilation of HEVs (on day 2) and later (on days 4 and 5) an increase in the height of high endothelial (HE) cells. A crucial role is ascribed to the altered HEV-adhesiveness in the increase of lymphocyte migration to the challenged lymph nodes.

Animals↗
PubMed1990

High endothelial venules in B-cell non-Hodgkin malignant lymphomas.

The number of high endothelial venules (HEVs) per unit area was determined in 55 B-cell non-Hodgkin malignant lymphomas (nHMLs) classified according to the Kiel classification. The number of HEVs per unit area was significantly different between low- and high-grade B-cell nHMLs. In the low-grade group, a large number of HEVs with preserved structure were present, whereas in high-grade tumours the HEVs appeared damaged. The present findings support the previous observation attributing prognostic relevance to lymphocyte recirculation in nHMLs.

B-Lymphocytes↗
PubMed1989

Endothelial cell receptors on leukemic plasma cells.

The binding of peripheral blood mononuclear cells of 7 patients with plasma cell leukemia to rat lymph node high endothelial venules has been studied in vitro. The mononuclear cells adhered selectively to the high endothelial venules. Their neoplastic origin was proved by in situ demonstration of their monoclonal cytoplasmic immunoglobulins. The in vitro binding of bone marrow mononuclear cells of 4 patients with multiple myeloma to high endothelial venules was also studied. In two patients there was no high endothelial cell binding. In the two others some adhering cells were observed. The plasmacytoid nature of these cells was, however, excluded for lack of cytoplasmic immunoglobulins. Since cells at the end stage of B-cell differentiation lose their surface receptors associated with lymphocyte recirculation, the presence of endothelium-recognizing structures on leukemic plasma cells seems to be remarkable.

Cell Adhesion↗
PubMed1982

[On the dissemination of B-cell non-Hodgkin lymphomas at the time of diagnosis].

The staging procedure as successfully used in Hodgkin's disease has proved to be less informative with respect to prognosis and therapy in the case of non-Hodgkin malignant lymphomas. This might be explained by the greatly differing degrees of dissemination of non-Hodgkin lymphomas at the time of diagnosis. In the present study, the dissemination of B-cell non-Hodgkin lymphomas diagnosed according to the Kiel classification was determined on the basis of clinical and pathomorphological findings. At the time of diagnosis, non-Hodgkin lymphomas of low grade malignancy tend to be statistically more disseminated and those of high grade malignancy more localized. It is assumed that this fundamental difference in dissemination between non-Hodgkin lymphomas of low grade and those of high grade malignancy can be explained by changes in the recirculatory properties of lymphomas cells and by some of their atypical features.

Autopsy↗
PubMed1980

Pathomorphology of acute lymphoblastic leukaemia in childhood: convolution of lymphoblast nuclei.

In the period between 1960--1978 36 children dead with acute lymphoblastic leukaemia (ALL) were studied. Nine cases were found to be in pathological remission, i.e., without any leukaemia infiltrations (7 of these were seen in the last 5 years). The remaining 27 could be divided into two groups on the basis of nuclear structure: in 20 cases the lymphoblastic nuclei were round or oval and their convolution was pycnotic, "highly convoluted", or lobulated, in 7 the nuclei were round or oval and their convolution was slight. The survival was 10.8 months in the first and 3.6 months in the second group. Although the origin and the degree of differentiation of the cells of these two groups are not clearly known, it seems that the two types represent different stages of T-lymphoblast evolution.

Adolescent↗
PubMed1980

[Pathomorphology of acute lymphoblastic leukemia. Gyrification of the nucleus of lymphoblast cells].

In 9 children out of 36 with ALL examined post mortem at the Department of Pathology of the Medical University of Pécs in the period 1960--1978 leukaemic infiltrates were not found at all ("total remission"). 7 cases out of the 9 observed during the last 5 years. The remaining 27 cases could be divided into two groups: at 20 children nuclei of the leukaemic cells have shown marked gyrification. Survival of children of this group was 10.8 months. At the remaining 7 children the surface of the cell nuclei appeared to be smooth. The survival in this group was 3.6 months. These data support the hypothesis according to which ALL of the children and T cell malignant lymphomas may be of two types. Those with gyrificated and with non-gyrificated nuclei. The considerable difference in survival of patients with these two types of leukaemia suggests that the morphology of the cell nuclei i.e. "gyrification" or "non-gyrification" of them may be used in estimation of the prognosis.

Adolescent↗