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Biomedical subjects

T Pang

Publications and source records attributed to T Pang.

At least 73 records · Page 4Linked to original sources
PubMed1991

Heat-killed Salmonella typhi induces the release of prostaglandins and leukotrienes from mouse macrophages.

Mouse macrophages pre-labeled with [3H]arachidonic acid (20:4) were shown to release metabolites generated by the lipoxygenase and cyclo-oxygenase pathways following in vitro addition of heat-killed Salmonella typhi. These metabolites were maximally released after 60-90 min of incubation and consisted of prostaglandins (85%), leukotriene C (6%), di-HETEs, leukotrienes D and E (4%), mono-HETEs (2%) and other metabolites (3%). Of the metabolites generated by the cyclo-oxygenase pathway (prostaglandins), 6-keto PGF1 alpha and PGE2 were generated at a ratio of 1.2 to 1. The significance and importance of these results are discussed.

Animals↗
PubMed1991

[Response properties of SI cortical neurons to electro-acupuncture and manual acupuncture in the rat].

Single SI cortical neurons were recorded extracellularly with glass micropipettes, and their response properties to electro-acupuncture (EA) of contralateral Tsusanli (St. 36) and Fenglung (St. 40), or to manual acupuncture (MA) of Tsusanli were observed in unanesthetized and paralyzed rats. In 46 rats, a total of 474 neurons were isolated in the hindlimb representation area of SI cortex. Among these neurons, 228 responded to peripheral mechanical stimulation, and could be classified as cutaneous neurons, deep neurons and cutaneous-deep convergent neurons. Thirty five of them were identified as nociceptive neurons. Neurons of various sensory neurons and with receptive fields (RFs) located in the contralateral hindlimb responded to EA. Significant difference (P less than 0.01) existed between the stimulation thresholds of cutaneous neurons (2.39 +/- 0.27V) and those of deep neurons (4.12 +/- 0.48V). There was no significant difference between the thresholds of nociceptive and non-nociceptive neurons. The typical response of SI neurons to single EA stimulation consisted of early discharges with a latency of 11.57 +/- 0.39 msec and late train discharges with a latency of 54.79 +/- 4.07 msec. A period of inhibition frequently intervened between the two groups of discharges. In a small portion of neurons, only a period of inhibition was produced. The responsiveness of neurons decreased markedly when the frequency of repeated EA stimulation was increased from 1 Hz to 50 Hz. Neurons of various sensory modalities responded to MA as well. Judging by RF distribution of the responsive neurons, however, the extent of action of MA was smaller than that of EA.(ABSTRACT TRUNCATED AT 250 WORDS)

Acupuncture Points↗
PubMed1990

Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin.

OBJECTIVE: To examine the safety and effectiveness of a low-molecular-weight heparin in the prevention of thromboembolism in patients with recent spinal cord injury and complete motor paralysis. DESIGN: Randomized evaluation of two heparin regimens in 41 consecutive patients meeting eligibility requirements for anticoagulant prophylaxis. Daily bedside examinations were supplemented by serial venous flow studies; suspicious or positive tests were confirmed by venography. INTERVENTION: Standard heparin, 5000 units subcutaneously three times a day; low-molecular-weight heparin 3500 anti-Xa units subcutaneously once daily. MEASUREMENTS AND MAIN RESULTS: Five patients in the standard heparin group had thrombotic events, including two patients with fatal pulmonary embolism; two other patients had bleeding severe enough to necessitate withdrawing the heparin. The cumulative event rate was 34.7% (95% CI, 13.7% to 55.2%). None of the patients treated with low-molecular-weight heparin had thrombosis or bleeding (CI, 0% to 14%). The difference between the two groups was significant (P = 0.006, log-rank test). CONCLUSIONS: Low-molecular-weight heparin is safe and effective in the prevention of thromboembolism in selected patients with spinal cord injury and complete motor paralysis, and is superior to standard heparin in fixed doses of 5000 units three times a day.

Administration, Cutaneous↗
PubMed1990

Pang replies.

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Journal Article↗
PubMed1989

A simple adherence test for detection of IgM antibodies in typhoid.

A simple adherence test to detect IgM antibodies in patients with typhoid is described. The test utilises the IgM-"capture" approach, in which the test serum is applied to microtitration plate wells previously coated with anti-human IgM, followed by application of a stained Salmonella typhi antigen suspension which shows adherence in positive cases. By this test, 58 (95%) of 61 sera from confirmed cases of typhoid possessed IgM antibodies to the H or O or both antigens of S. typhi. In patients for whom a diagnosis of typhoid was based only on a significant Widal-test titre, 31 (41%) of 76 sera had IgM antibodies to the H or O or both antigens of S. typhi. Some cross-reactivity of the IgM antibodies was detected, especially with the O antigens of S. paratyphi A and B. A total of 82 sera from non-typhoidal fevers (leptospirosis, typhus, dengue fever) showed no reactivity in this test. In normal sera there was no detectable IgM to the O antigen of S. typhi and only a small number (3.9%) had low levels of IgM to the H antigen. The significance and potential importance of this simple, sensitive, specific and economical test is discussed.

Antibodies, Bacterial↗
PubMed1989

A practical community-based approach to the diagnosis of dengue virus infections.

A study is described in which private physicians participated in the surveillance and diagnosis for dengue disease within a community. Using simple, economical methods it was shown that a significant proportion of specimens submitted were positive for dengue infection. Of 610 fingerprick blood specimens collected on filter paper strips, 7% to 33% were positive by serology. Of these specimens, 423 (69%) were single specimens and 92 (22%) of the single specimens were positive by serology. Of 153 fingerprick blood specimens collected in heparinized, glass capillary tubes, 15% to 50% yielded a dengue virus isolate. When a positive result was based on serology and/or virus isolation, an overall positive rate of 39% was obtained for one of the participating clinics. Inclusion of thrombocytopenia and leukopenia in selection of cases significantly improved the positive rate. It is argued that this simple and practical community-based approach will result in more accurate surveillance of dengue transmission within an endemic area and thus aid in the development of long-term strategies for control of disease.

Dengue↗
PubMed1988

T cell-mediated cytotoxicity against dengue-infected target cells.

A cytotoxic T lymphocyte (CTL) response to dengue virus-infected target cells is described. Effector cells were generated in an in vitro secondary culture and appeared to be T cells possessing both the Lyt 1.1 and Lyt 2.1 surface antigens. A stronger CTL response was noted with the H-2k haplotype compared to H-2d, and H-2 compatibility was required between CTL and target cells. CTL generated showed some cross-reactivity with target cells infected with Japanese encephalitis virus (JEV), another flavivirus, but not with target cells infected with an alphavirus, Sindbis. The significance and importance of these findings are discussed.

Animals↗