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Biomedical subjects

T P Romanova

Publications and source records attributed to T P Romanova.

10 recordsLinked to original sources
PubMed2004

[Age-related comparative characteristics of ulcer disease course].

AIM: To study pathogenetic factors underlying development of ulcer disease and its course in different age periods. MATERIAL AND METHODS: Clinical, psychoemotional, endoscopic device, biochemical and radioimmunological examinations were used in the study of 283 patients with gastroduodenal ulcer. By age, the patients were divided into four groups: 15-18, 19-35, 36-60 and 61 and older. RESULTS: Some age-specific clinical and endoscopic characteristics were found in the examinees. Risk factors (hereditary predisposition, high gastric juice acidity, the presence of Helicobacter pylori, etc.) occurred almost with the same frequency at different ages. Older patients had deficient defense-protection properties of gastric mucus. Most of the examinees's psycho-emotional state was characterized by moderate reactive and high personality anxiety. In all the age groups reactions of the hormonal system were of the same type--hypophyseo-adrenal hyperfunction and hypophyseo-thyroid hypofunction. CONCLUSION: The above findings may help in design of differentiated by age therapeutic and diagnostic measures for ulcer patients of different age.

Adolescent↗
PubMed1992

[Sex differences in adrenocortical sensitivity and resistance to cerebrovascular damage in rats under strong stress].

Dynamics of changes in adrenal and plasma corticosterone and the development of cerebrovascular lesions were studied in both male and female rats, exposed to strong stress (combined immobilization and intermittent found sound for 2 hours). Plasma corticosterone levels in stressed females were 460% and 660% of the control values when measured on stress minute 10 and 120. The corresponding values in male rats were 220% and 360%. The stress-induced dilatation of brain vessels and the increases in vascular permeability were less pronounced in females than in males, when studied 0.1 and 24 hours after termination of stress. The number of brain perivascular haemorrhages was markedly reduced in females compared with males. It is supposed that higher resistance to stress-induced cerebrovascular lesions in females may be attributed to higher functional reserves of steroidogenesis.

Acoustic Stimulation↗
PubMedDate not supplied

[Mechanism of disorders of the cerebral blood supply during stress in spontaneously hypertensive rats].

The immobilization- and sound stimulus-induced changes in cerebral circulation were studied in spontaneously hypertensive rats. It was found that there was a stress-induced increase in the levels of epinephrine and norepinephrine in brain tissue, which was associated with lower levels of vasoactive prostaglandins E and F2 and with their imbalance with vasodilator prostaglandins E being prevalent. The change in the cerebral ratio of biologically active substances results in cerebral blood flow autoregulation failure and development of large cerebral hemorrhages.

Animals↗
PubMedDate not supplied

[Change in prostaglandin levels and ATPase activity of cardiac membrane fractions during the formation of cerebral hematomas in animals with a hereditary predisposition to stroke].

The formation of subarachnoidal, intragastric, and intracerebral hepatomas provoked by stress in rats hereditarily predisposed to strokes was found to be accompanied by myocardial overstrain and changes in cardiac prostaglandin formations, as well as by a decrease in the activity of ion-transporting enzymes, such as Na, K- and Ca,Mg-ATPases in the plasma membranes, Ca-ATPase in the sarcoplasmic reticulum.

Adenosine Triphosphatases↗