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Biomedical subjects

T Onoe

Publications and source records attributed to T Onoe.

At least 37 records · Page 2Linked to original sources
PubMed1983

Malignant fibrous histiocytoma of the heart.

A case of cardiac sarcoma was reported. The tumor, which arose from the posterior wall of the left atrium, was demonstrated by echocardiography, contrast-enhanced computed tomography and direct observation during surgery. The tumor was successfully excised under emergency operation and was diagnosed as malignant fibrous histiocytoma after histologic examination. The patient had been free of symptoms for several months, but died of rapidly progressive congestive heart failure 6 months after surgery.

Echocardiography↗
PubMed1982

Hemodynamic effects of concomitant nitroglycerin ointment and nifedipine treatment in acute myocardial infarction.

Nitroglycerin ointment and nifedipine were used concurrently for vasodilator therapy in 10 patients with acute myocardial infarction. Nitroglycerin ointment 20 mg (4 cm) induced a significant reduction in pulmonary capillary wedge pressure from 14.1 +/- 1.8 (mean +/- standard error of the mean) to 12.4 +/- 1.2 mmHg (p less than 0.05) 30 min after application, while cardiac output, mean blood pressure, and systemic vascular resistance did not show a significant change. When nifedipine 10 mg was added orally, mean blood pressure significantly decreased from 99.0 +/- 6.3 to 82.8 +/- 5.9 mmHg (p less than 0.005) and systemic vascular resistance from 25.7 +/- 1.5 to 19.2 +/- 1.6 units (p less than 0.001) 30 min after; on the other hand, cardiac index significantly increased from 2.28 +/- 0.12 to 2.57 +/- 0.14 l/min/m2 (p less than 0.001). From these results, it was concluded that combined use of these two drugs was a useful and safe form of unloading therapy.

Aged↗
PubMed1982

An ultrastructural study of subacute necrotizing lymphadenitis.

Fifteen cases of a unique lymphadenitis called subacute necrotizing lymphadenitis were studied electron-microscopically. The large lymphoreticular cells proliferating at cortical or paracortical areas of the lymph nodes mainly consisted of immunoblasts and histiocytoid cells, which were characterized by numerous intracytoplasmic myelinlike inclusions. Such histiocytoid cells seemed to be derived from the immunoblasts. Tubuloreticular structures, which had been often noticed within endothelial cells or lymphocytes of the patients with systemic lupus erythematosus (SLE) or SLE-related diseases, were also observed with high frequency in most cases examined. They were present within the cytoplasm of immunoblasts, endothelial cells, and histiocytoid cells. Immunoblasts in mitosis occasionally contained these structures. We offer the hypothesis that subacute necrotizing lymphadenitis with still unknown etiology may reflect a self-limited SLE-like autoimmune condition induced by virus-infected transformed lymphocytes.

Adolescent↗
PubMed1982

Histochemical and cytochemical study of butyrylcholinesterase activity in rat hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazobenzene.

The activity of butyrylcholinesterase (BCHE), a liver fetal isozyme (Zone L-V) of a nonspecific esterase, was studied histochemically and cytochemically in rat hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). In normal adult rats, BCHE activity was very prominent in cells of the intestinal mucosa but was not detectable in the liver. On the other hand, in fetal rat liver, a few cells scattered throughout the organ were BCHE positive. 3'-Me-DAB induced poorly differentiated hepatocellular carcinomas showing an intense BCHE activity, especially in areas consisting of small tumoral cells proliferating in a sheet-like pattern. Surrounding noncancerous liver tissue was completely devoid of reaction products. Less-differentiated trabecular hepatocellular carcinomas also showed a positive reaction. On the other hand, well-differentiated hepatocellular carcinoma and hepatocellular carcinoma with an adenomatous pattern were barely stained, while areas of cholangiofibrosis were usually negative. Thus, in confirmation of a previous report, BCHE appears to be a positive marker of poorly differentiated hepatocellular carcinomas induced by 3'-Me-DAB. By electron microscopy, reaction products were demonstrated in the cisternae of the endoplasmic reticulum, in the nuclear envelopes, and sometimes on the cell surface of undifferentiated tumoral cells. The significance of the appearance of BCHE activity in hepatocellular carcinomas induced by 3'-Me-DAB is discussed.

Animals↗
PubMed1981

Three main coronary arteries to pulmonary artery fistula.

A case of a 19-year-old woman with coronary artery fistula was reported. She was asymptomatic throughout her life. Physical examination revealed a continuous murmur along the left sternal border. Echocardiograms and left ventriculograms showed mitral valve prolapse. Selective coronary arteriograms disclosed arteriovenous fistula between branches of the right, the left anterior descending and the left circumflex coronary artery and the main pulmonary trunk. We believe that this is the first case report of an unusual form of anomalous coronary-pulmonary artery communication: three main coronary vessels participate in the fistula.

Adult↗
PubMed1980

Demonstration of embryonic-type hemoglobin in extramedullary hematopoietic cells in the liver during experimental liver carcinogenesis by 3'-methyl-4-dimethylaminoazobenzene.

Using an immunofluorescent technique, we demonstrated the production of rat embryonic-type hemoglobin in extra-medullary hematopoietic cells, which appeared in the liver of adult Wistar rats fed a diet containing 0.06% 3'-methyl-4=dimethylaminoazobenzene. Specific anti-rat embryonic hemoglobin serum was prepared by immunizing a rabbit with hemoglobin from a 15- or 16-day-old Wistar rat fetus and absorbing with adult rat liver hemogenate and red blood cells. The appearance of hematopoietic foci was observed at both precancerous and cancerous stages during 3'-methyl-4-dimethylaminoazobenzene-induced liver carcinogenesis. At the cancerous stage, almost all these foci were observed in poorly differentiated hepatocellular carcinomas. The hematopoietic cells seen at both stages were stained positively with antiembryonic hemoglobin serum, but red blood cells and other types of cells in the liver did not show this specific fluorescence. These results together with earlier observations on the appearance of fetal characteristics strongly suggest that a fetal environment prevails in the adult rat liver during hepatic carcinogenesis.

Animals↗
PubMed1979

A microsomal butyrylesterase appearing in rat livers during development, regeneration, and carcinogenesis, and after phenobarbital treatment.

A microsomal butyrylesterase (L-I) was purified from the livers of male W rats treated with phenobarbital, and an antiserum against this purified L-I was raised in a rabbit. By the Ouchteriony double-diffusion test, a precipitin line was observed between the anti-L-I antiserum and each Triton X-100 extract of livers during development, regeneration after partial hepatectomy, and carcinogenesis and of hyperplastic nodules and hepatomas, all of which revealed L-I in their esterase isoenzyme patterns. These precipitin lines exhibited esterase activity. The fusion of the lines of these tissue extracts and that of the purified L-I indicated the presence of an antigen site common to their esterases. The extracts of adult and fetal livers and also of hepatomas resembling fetal liver in the esterase isoenzyme pattern did not produce a precipitin line with anti-L-I antiserum.

Animals↗