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Biomedical subjects

T Ono

Publications and source records attributed to T Ono.

At least 955 records · Page 53Linked to original sources
PubMed1989

[Body temperature of newborn cynomolgus monkeys].

This report dealt with the change of body temperature (rectal temperature) in the newborn cynomolgus monkeys (Macaca fascicularis) with a view to take it as an index for their health conditions. The body temperatures of 183 newborn babies which were well cared for by their mothers was 33.0 to 37.7 degrees C about 10 hr after birth. On the other hand, the body temperatures of 21 newborn babies which were not well cared for by their mothers was very low, ranging from 24.1 to 34.8 degrees C. In five newborn monkeys which were well cared for, the body temperature averaged about 36 degrees C just after birth and then declined rapidly by 32 to 33 degrees C at 40 to 50 minutes after birth. Then it gradually began to rise, reaching 36 to 37 degrees C at 180 to 240 min after birth. In the other four newborn monkeys which were delivered by Caesarean section, the temperature was 37 to 38 degrees C just after birth. Then it decreased to 29 to 32 degrees C at 120 minutes after birth when the newborns remained singly in a cage without warming.

Animals↗
PubMed1989

[Numerical anomaly of teeth in mongrel juvenile dogs. Canis familiaris].

As this study subjects, upper and lower dentitions of 49 mongrel dogs were used. X-ray films of the upper and lower dentitions of the dogs were taken. These films were from the collection of the Department of Pedodontics, School of Dentistry, Aichi-Gakuin University. Although the data on the sex and age of the dogs were not available, the dental ages were judged to range from the deciduous dentition to the early mixed dentition. Molars were not dealt with in this study for two reasons: 1) the molars of many of the subjects had not yet been calcified, and 2) the upper second and/or lower third molars, if present, had frequently been sacrificed when the jaws were separated. Numerical anomalies were observed in 16 dogs (32.7%). And infranumerary teeth were observed in 14 dogs (26.8%). Incidences of infranumerary teeth were higher in the secondary dentitions than in the primary ones. Most of the infranumerary teeth were found in both the upper and lower premolars, but not in the upper incisors and the upper and lower canines. Infranumerary teeth often occurred symmetrically whereas supernumerary teeth occurred asymmetrically. This investigation suggests that tendency of the reduction of the upper third premolar was considered to be caused by the reduction of the maxilla through the process of domestication. These results are inconsistent with Fujita's terminal reduction theory.

Animals↗
PubMed1989

Malignant mesotheliomas in Kure City, Japan: the relationship of asbestos exposure.

Eighteen patients with malignant mesothelioma were seen at Kure Mutual Aid Hospital over a 10-year period. According to occupational history, chest x-ray manifestations, and evidence of asbestos bodies in the tissue, 13 of these cases were definitely thought to be due to exposure to asbestos as a result of two or three of these items testing positive. Kure City is one of the major ship-building cities in Japan since the 1920s. Most of the 18 patients worked in ship building before and during World War II. Malignant mesothelioma appeared about 40 years after their first exposure to asbestos. In western countries, most malignant mesotheliomas are thought to be induced by exposure to asbestos fibers (1,2). Consequently, there has been a serious effort to deal with this problem recently, including lowering rate of exposure. In Japan, however, there have been few reports that asbestos fibers caused malignant mesothelioma (3). This report suggests that an increased incidence of malignant mesotheliomas in a specific area of Japan may also be due to exposure to asbestos fibers.

Adult↗
PubMed1989

[Application of occlusal splint for the patient with temporomandibular joint dysfunction. An application of silane coupling treatment: a case report].

The bite plane therapy has been one of the most useful treatment methods for patients with temporomandibular joint (TMJ) dysfunction. But the bite plane usually causes esthetic and articulation disturbances and it is occasionally difficult to use during mastication. The authors have fabricated a new type of bite plane, named occlusal splints, which covers each side of the premolars and molars. The occlusal splint was constructed by a hard-resin for the occlusal part and cast clasps for the retentive part and these parts were adhered after a pre-treatment of metal by the use of a silane coupling agent (Silicoater system). The patient was a 35 year-old man, with a chief complaint of left side reciprocal TMJ clicking. The anterior repositioning type of bite plane was applied for the treatment with the diagnosis of anterior disk displacement with reduction. But he complained of esthetic and articulation disturbances especially during working and eating. After four months we fabricated an occlusal splint that can be used for a long period of time. The patient was satisfied to use this occlusal splint and no symptoms of TMJ dysfunction were found with this appliance. It is suggested that the occlusal splint consisting of a hard-resin and cast clasps is a useful appliance especially for the purpose of use during working and eating, and for evaluating the properness of mandibular position.

Adult↗
PubMed1989

[A new edentulous model maintained at body temperature].

We have produced a new edentulous model, which is maintained at the human body temperature, for higher grade model practice and pre-clinical education. A soft material, its thickness based on the value of the oral mucosa, covers the surface of this model. It takes 4 minutes to reach the body temperature after turning on the switch, and it consumed about 9 watts per hour. This new model is useful for teaching clinical characteristics of impression materials in which the setting time is influenced by the temperature. Improvements are under consideration to fit some thermal and pressure sensors to the buccal and labial parts to make a more sophisticated patient simulator.

Body Temperature↗
PubMed1989

Age-dependent and tissue-specific changes of DNA methylation within and around the c-fos gene in mice.

The degree of DNA methylation in the c-fos gene and its vicinity in liver, brain and spleen of mice of different ages was examined using methylation-sensitive restriction endonucleases. The gene had an invariable unmethylated domain from 1.8kb upstream of the cap site to the first intron. The domain was flanked on both sides with partially methylated areas, where tissue-specificity and age-dependent changes were observed. The tissue-specificity was found on the 14th day of gestation. Increases of methylation were observed during the late fetal and one month postnatal developmental periods in the three tissues. After that, the methylation states remained unchanged. One exception was seen in the exon 2 area in liver, where methylation continued to increase throughout life. This revealed the importance of the late fetal- and post-natal developmental periods in the establishment of tissue-specificity in DNA methylation profiles and further showed that some of the developmental changes could extend into the senescent phase.

Aging↗
PubMed1989

[Combination effect of UFT and gamma-irradiation against nude mice transplanted KB cells].

Combination effect of UFT and gamma-irradiation was examined using KB cell transplanted in nude mice. KB cell line is known as derived from human malignant tumor of the mouth floor. Although treatment with UFT or with gamma irradiation did not suppress the tumor growth, combination of these two treatments caused a marked suppression. Especially, when UFT was administered to the mice successively from the time of transplantation and the irradiation was applied after tumor growth, both suppression of the tumor growth and necrosis of the tumor tissue were observed.

Animals↗
PubMed1989

[A case of synchronous double primary malignant neoplasms (malignant astrocytoma, and lung cancer) diagnosed by autopsy].

Discussed is a deceased patient, a 54-year-old male, who was admitted to hospital with the chief complaint of motor aphasia. Computed assisted tomography in the cranium showed a massive lesion in the left brain. Further, chest X-ray showed an abnormal tumorous shadow with a pleural indentation in the left middle lung field. In spite of a negativity of cancer cells in a bronchial biopsy and a brushing, we decided that this case reflected a lung cancer with brain metastasis. However, on autopsy, the tumor in the lung histologically was determined as being an (adenocarcinoma alveolar cell type) and the brain tumor was found to be a malignant astrocytoma. We have reported on this case because a double primary neoplasm, a malignant astrocytoma and lung cancer, is rare in the literature.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1989

[Atypical myrmecia--on the importance of the anatomical site of HPVs-infection as a morphological factor].

An 11-year-old Japanese girl developed a horny tumor branching into three parts in the fourth interdigital fold of the left hand; histologically it had numerous eosinophilic granular inclusion bodies. A histological diagnosis of myrmecia was made, which was further confirmed by the demonstration of human papillomavirus type 1 (HPV-1) by the in situ hybridization method. However, the clinical picture did not resemble the so-called myrmecia. A review of other atypical cases of myrmecia on areas other than the palms and soles may indicate the role of topical factors in determining the shape of viral warts. The concept of myrmecia should be revised in view of the additional information that there is histological heterogeneity in the cytoplasmic inclusion bodies, which are the basis of the definition of myrmecia.

Child↗
PubMed1989

[Cervico-thoracic-abdominal lymph node dissection for carcinoma of the thoracic esophagus].

Over the period from 1982 to 1988, 127 cases with carcinoma in the thoracic esophagus underwent curative resection through a right thoracotomy. Cervicothoracic-abdominal lymph node dissection was performed in twenty-seven cases. No operative death occurred and only one hospital death (4%) was recorded. The only postoperative complication was recurrent laryngeal nerve palsy. Based on the adjusted survival-rate curves using Cox's method, there was significant difference in prognosis in favor of these 27 cases that received cervicothoracic-abdominal lymph node dissection over those that did not. The survival rate of all curatively operated cases was noticeably improved by using this procedure. Of those that underwent dissection only, or dissection with postoperative radiotherapy or chemotherapy, the best prognosis could be reached by a combination of the cervicothoracic-abdominal lymph node dissection and postoperative chemotherapy. From follow-up data regarding recurrence rates, a more extended dissection and complete removal of lymph nodes in the left upper mediastinum and retroperitoneum should further improve the long-term prognosis.

Abdomen↗
PubMed1989

[A case of epilepsy presenting periodic synchronous discharges and recruiting rhythm for a long time].

A case of secondary generalized epilepsy (47 years old, male) presenting the periodic synchronous discharges (PSD) consisted of sharp waves or sharp and slow waves, and recruiting rhythm (RR) for several years was shown. PSD, of which duration was 10-40 sec, was seen most prominently when he was awake and relaxed, although it was also found during both wakefulness and sleep. On the other hand, RR with a duration of 1-5 sec was observed only during NREM sleep (stage 2 and 3). There was no clinical manifestation associated with PSD and RR, except for the eye-opening behaviors occasionally seen during RR. From the electroencephalographic features of PSD and RR, and the other previous reports concerning them, it was speculated that an association of diffuse cortical and brain stem dysfunctions was responsible for both PSD and RR. In addition, the similarity and dissimilarity of PSD and RR with the slow spike and wave complex and rapid rhythm chiefly seen in the Lennox-Gastaut syndrome were discussed. It was stressed that whether the slow spike and wave complex and rapid rhythm were specifically related to the Lennox-Gastaut syndrome should be reappraised.

Electroencephalography↗
PubMed1989

[Evaluation of primary multiple cancer manifesting exposure to asbestos].

Twenty five cases (71%) of 35 primary multiple cancer, confirmed by autopsy, were proved to have been exposed to asbestos. Of these cases, lung and stomach cancers, which were related to the asbestos exposure, were main component of the multiple cancers. Thirteen of these cases had definite occupational histories of asbestos exposure and the number of asbestos bodies in five grams of autopsied wet lung tissue amounted to more than 1000. This result suggests that asbestos exposure might possibly induce a high incidence of multiple cancers.

Aged↗
PubMed1989

Binding of the new calcium entry blocker nilvadipine to rat aortic and guinea pig left ventricular membranes.

The binding of 3H-nilvadipine to the vascular (rat aortic) and cardiac (guinea pig left ventricular) microsomes was reversible and saturable. The results of the competitive binding experiments showed that nilvadipine had a higher affinity (Kd: 1.5 +/- 0.2 nmol/l) for the vascular binding sites than did nifedipine (Kd: 10.7 +/- 0.8 nmol/l) and nicardipine (Kd: 6.9 +/- 2.0 nmol/l), while the affinity of nilvadipine for the cardiac binding sites (Kd: 3.8 +/- 0.4 nmol/l) was similar to that of nifedipine (Kd: 3.3 +/- 0.1 nmol/l) and nicardipine (Kd: 4.2 +/- 0.3 nmol/l). The time courses of dissociation of the unlabeled dihydropyridines from the vascular binding sites were investigated using 3H-nitrendipine. Nilvadipine and nicardipine dissociated more slowly from the binding sites than did nifedipine. These results suggest that the high potency, selectivity for the vascular smooth muscle and long duration of action of nilvadipine may be related to its binding properties.

Animals↗
PubMed1989

[A case of adenocarcinoma of the nasal cavity associated with syndrome of inappropriate secretion of antidiuretic hormone(SIADH)].

An inappropriate antidiuretic hormone secretion (SIADH) has been recognized as the cause of hypotonic hyponatremia, and the occurrence of this syndrome, accompanied by an ADH-producing adenocarcinoma in the nasal cavity, is reported. In February, 1987, a 50-year-old male, showing sights of delirium, disorientation, and irritability was admitted to the hospital. The patient was observed to be healthy, except for a neck lymphnode metastasis that was present up to the time of his hospitalization. The hyponatremia was incidentally found, although dehydration or intravascular volume depletion were not noted. These neuropsychiatric symptoms were considered to be associated with hyponatremia due to SIADH. He had had a partial maxillectomy, a neck dissection, and irradiation to the nose and nasal cavity 32 months earlier, and then underwent a surgical resection of the neck metastasis; he had a total of 10 other operations before the onset of the symptoms. Upon initial inspection, since neither an intracranial invasion nor a brain metastasis was found, we diagnosed that his symptoms were due to an autonomic disturbance caused by surgical and mental "stress". When he died of cardiac failure due to a mediastinal invasion 8 months after the onset of SIADH, tumor tissues was extirpated in an autopsy and was then cultured. In this manner, it was proved that the tumor cells had been producing ADH. This procedure clarified that the syndrome had resulted from an ADH-producing tumor of the nasal cavity.

Adenocarcinoma↗
PubMed1989

Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease.

Age-related changes of the condyle of the temporomandibular joint (TMJ) in strains of Senescence Accelerated Mouse (SAM) were investigated. With advancing age, all strains of SAM showed degenerative joint disease initiated by degenerative changes such as eg, roughness, fissure, and erosion on the condylar surface. These degenerative changes were in concert with an active remodeling that can lead to deformation of the condyle. Moreover, the short-lived SAM-P (accelerated senescence prone mouse) strains developed these degenerative changes earlier than did the SAM-R (accelerated senescence resistant mouse) strains. Thus, development of degenerative joint disease in SAM was closely related not only to chronological age but also to the accelerated senescence phenomenon. Of the SAM-P series, the SAM-P/3 strain was the first to manifest degenerative changes (approximately 50% at 7 to 9 months of age and 100% over 12 months of age) and thereafter showed the highest incidence of severe changes with overt deformity. As a model of degenerative joint disease, this strain of SAM should prove useful.

Aging↗