Biomedical subjects

T Oki

Publications and source records attributed to T Oki.

At least 433 records · Page 24Linked to original sources

PubMed1976

Clinical features and treatment of joint dislocations in Larsen's syndrome. Report of three cases in one family.

Of 3 cases of Larsen's syndrome in one family, one had bilateral dislocation of the hip and the knee joints. The knee joint was not reduced by manipulation and corrective cast, while both hip and knee joints were simultaneously reduced by skeletal traction of the tibia at the age of 4 months, and the course was satisfactory. Reduction of joint dislocations should be attempted by a conservative method such as skeletal traction as early as possible. Various radiographic skeletal abnormalities occurred in all 3 cases. Larsen's syndrome very likely has a genetic origin.

Abnormalities, Multiple↗

PubMed1975

Purine nucleotide pyrophosphotransferase from Streptomyces morookaensis, capable of synthesizing pppApp and pppGpp.

Purine nucleotide pyrophosphotransferase was purified to apparent homogeneity from a culture filtrate of Streptomyces morookaensis. It is a monomeric protein with a molecular weight of 24 000-25 000, and its isoelectric point is 6.9. The enzyme synthesizes purine nucleoside 5'-phosphate (mono, di, or tri) 3'-diphosphates such as pppApp, ppApp, pApp, pppGpp, ppGpp and pppIpp by transferring a pyrophosphoryl group from the 5'-position of ATP, dATP and ppApp to the 3'-position of purine nucleotides. The purified enzyme catalysed the formation of 435 mumol of pppApp and 620 mumol of pppGpp from ATP and GTP per min mg protein under the standard conditions. The enzyme requires absolutely a divalent cation for activity, and optimum pH for the enzyme activity lay above 10 for Mg2+, for Co2+ and Zn2+ from 9 to 9.5, and for Fe2+ from 7.5 to 8. The following Michaelis constants were determined: AMP, 2.78 mM; ADP, 3.23 mM; GMP, 0.89 mM; GDP, 0.46 mM and GTP, 1.54 mM, in the case of ATP donor. The enzyme is inhibited by guanine, guanosine, dGDP, dGTP, N-bromosuccinimide, iodacetate, sodium borate and mercuric acetate.

Adenosine Triphosphate↗

PubMed1975

Anterior mitral valve echo in patients with isolated ventricular septal defect and with tetralogy of Fallot.

Eight patients with isolated ventricular septal defect and two patients with tetralogy of Fallot were studied by UCG. Two of these patients showed notchings and five showed flutterings on F-A portions of the anterior mitral leaflet echoes. Fluttering seemed to be recorded more frequently in patients with right-to-left shunts such as cyanotic tetralogy of Fallot. It was considered that these functional changes of mitral valve echoes during diastole would be caused by the direction and amounts of blood flow across the defect and the velocity and amounts of blood flow through the mitral valve. Fluttering of mitral valve echo during diastole may be observed in normal subjects or in patients with other cardiac abnormalities, such as aortic insufficiency, atrial fibrillation or flutter. Flutterings seen in ventricular septal defect and tetralogy of Fallot are, however, of low amplitudes and of high frequencies, and are observed mainly between F and A points.

Adolescent↗

PubMed1975