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Biomedical subjects

T Okazaki

Publications and source records attributed to T Okazaki.

At least 523 records · Page 29Linked to original sources
PubMed1975

Histamine release from human leukocytes: modulation by cadmium ion.

The effect of cadmium on histamine release was studied in relation to the role of calcium. The antigenic histamine release from peripheral leukocytes of ragweed-sensitive patients was inhibitied in the presence of cadmium (greater than 10(-5) M). Spontaneous histamine release was not affected by cadmium except for an enhancement observed in high concentrations (greater than or equal to 10(-3)M). Cadmium did not seem to affect the first stage of histamine release but to act mainly on the calcium-dependent second stage. Increasing the level of calcium in the medium could antagonize the inhibitory effect of cadmium. The effect of cadmium could be totally abolished by deuterium oxide and partially by dibutyryl cyclic adenosine monophosphate (AMP) in certain concentrations. These results would indicate that: (1) cadmium acts as an antagonist of calcium and can be used for the study of the role of calcium in histamine release, (2) the action of calcium in the histamine release reaction seems to be related to the microtubular system, (3) cyclic AMP may potentiate histamine release when the action of calcium is inhibited.

Cadmium↗
PubMed1975

Studies on marine microorganisms. IV. A new antibiotic SS-228 Y produced by Chainia isolated from shallow sea mud.

A new antibiotic named SS-228 Y, which inhibits growth of Gram-positive bacteria, Ehrlich carcinoma in mice, and dopamine-beta-hydroxylase, was obtained from a species of Chainia isolated from shallow sea mud in Sagami Bay. It was yellowish brown powder having the molecular formula C19H1406. From the physical and chemical properties, SS-228 Y was concluded to b a new antibiotic having structure of peri-hydroxyquinone moiety.

Actinomycetales↗
PubMed1975

Effects of electrical stimulation on human ovarian contractility.

Electrical stimulation was applied to the follicular walls, capsules of corpora lutea, and pieces of atrophic ovaries obtained from 29 human ovaries. The quantitative analysis of contractile capacity in these ovarian strips was performed on the basis of stimulation-response relationships. Only with follicular walls and capsules of corpora lutea was the step linear dose-response relationship similar to that shown by the uterine rube obtained by alternating current stimulation. The basal portions of mature follicular walls showed much more distinct responses to AC-stimulation than the apical portions. This difference further indicates a possible role of contractions by basal follicular walls in the process of follicular rupture at the apex in the human ovulation. The contractile elements of these ovarian strips were electronmicroscopically investigated with the strips which had shown contractions and confirmed to be smooth muscle cells in the ovary.

Adult↗