Biomedical subjects

T Okabe

Publications and source records attributed to T Okabe.

562 records · Page 32Linked to original sources

PubMedDate not supplied

Human trophoblastic cells metabolize 25-hydroxyvitamin D3 in vitro.

Human trophoblastic cells (T3M-3) metabolized 25-hydroxyvitamin D3 into two more polar metabolites during in vitro incubations. A two-step high pressure liquid chromatography system revealed two unique elution positions of those trophoblastic cell-derived metabolites that exactly co-migrated with the elution positions of 5(Z)-19-nor-10-oxo-25-hydroxyvitamin D3 and 5(E)-19-nor-10-oxo-25-hydroxyvitamin D3, respectively. These unique metabolites did not bind specifically to a protein receptor for 1,25-dihydroxyvitamin D3.

Calcifediol↗

PubMedDate not supplied

Gallbladder carcinoma with choledochoduodenal fistula: a case report with surgical treatment.

A 79 year-old man was admitted to our hospital because of upper abdominal pain and nausea. A mobile tumor was palpable in the right upper abdomen. Abdominal ultrasonography, computed tomography and celiac angiography revealed a gallbladder tumor. Endoscopic retrograde cholangiopancreatography revealed a fistula 1.5 cm oral to the orifice of the papilla of Vater, dilatation of the common bile duct, and a filling defect in the gallbladder. Pancreatoduodenectomy associated with reconstruction using Imanaga's method was performed under a pre-operative diagnosis of gallbladder carcinoma with choledochoduodenal fistula. The gallbladder contained a tumor and two bilirubin stones impacted in the orifice of the duodenal papilla. Histological studies confirmed that the gallbladder tumor was a mucinous adenocarcinoma and had not infiltrated the bile duct. We speculated that choledochoduodenal fistula stimulated the development of cancer due to chronic irritation from pancreatic juice reflux.

Aged↗

PubMedDate not supplied

PACS in Japan and the Nordic Countries. First Japan-Nordic PACS symposium.

The ingredients seem to exist for switching from film-based radiology to digital radiology utilizing the concept Picture Archiving and Communication System (PACS). Why has this not happened? What are the barriers limiting the diffusion of PACS into health care? This was the theme of the 1st Japan-Nordic Symposium in PACS, which was held in Tokyo, March 29-30, 1990. Over 40 radiologists and technical specialists in PACS participated. The topics discussed ranged from the present status of PACS in Japan and the Nordic Countries, to functional specifications and user requirements for PACS, to organizational and other changes brought about by PACS and to teleradiology as a solution for communication of images over wide distances. The symposium was quite successful and will be followed by a 2nd symposium in Finland in the summer of 1991.

Humans↗

PubMedDate not supplied

Local pathological reactions and immune response of chickens to ISA-70 and other adjuvants containing Newcastle disease virus antigen.

Chickens were examined for gross and microscopic changes at the injection site for 16 weeks after an intramuscular injection of the following oil adjuvant emulsions containing inactivated Newcastle disease virus (NDV) antigen: ISA-70, Freund's incomplete adjuvant (FIA), Freund's complete adjuvant (FCA), and aluminum phosphate gel (APG). The reactions induced by ISA-70 emulsion were characterized by proliferation of macrophages, epithelioid cells, and fibroblasts around the small cysts in the muscle. Infiltration of lymphocytes and plasma cells also was present. These changes peaked 2 weeks postinjection and were milder than lesions due to the Freund's adjuvants. FCA induced the most severe granulomatous lesions with abscess formation. The reactions to APG were characterized by proliferation and accumulation of macrophages. The serological results revealed that the enhancing effect of ISA-70 on NDV antigen was the same as that of FIA.

Adjuvants, Immunologic↗